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| Title: | | HUMAN TOPOISOMERASE I (TOPO70) DOUBLE MUTANT K532R/Y723F | |
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| Molecular Description: |
DNA topoisomerase I (E.C.5.99.1.2)/DNA Complex |
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| Structural Features: | B DOUBLE HELIX |
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| Nucleic Acid Sequence: |
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| Protein Sequence: |
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| Primary Citation: | Interthal, H., Quigley, P.M., Hol, W.G., Champoux, J.J.
The role of lysine 532 in the catalytic mechanism of human topoisomerase I.
J.Biol.Chem.
, 279,
pp. 2984 - 2992, 2004.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
1
21
1
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| Cell Constants: |
| a = 56.944 | b = 118.638 | c = 71.651 | (Ångstroms) |
 = 90.00 |  = 98.33 |  = 90.00 | (degrees) |
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| Refinement: | The structure was refined using the REFMAC 5.1.24 program.
The R value is
27.7
for 14675 reflections
in the resolution range 47.67 to
3.13 Ångstroms
with Fobs > 0.0 sigma(Fobs).
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