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| Title: | | CRYSTAL STRUCTURE OF HUMAN TYROSYL-DNA PHOSPHODIESTERASE COMPLEXED WITH VANADATE, PENTAPEPTIDE KLNYK, AND TETRANUCLEOTIDE AGTC | |
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| Molecular Description: |
Tyrosyl-DNA Phosphodiesterase (E.C.3.1.4.-)/Topoisomerase I-Derived Peptide/DNA complex |
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| Structural Features: | SINGLE STRAND |
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| Nucleic Acid Sequence: |
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| Chains | D,F: | | (DA) (DG) (DT) (DC) |
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| Protein Sequence: |
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| Primary Citation: | Davies, D.R., Interthal, H., Champoux, J.J., Hol, W.G.
Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes.
J.Med.Chem.
, 47,
pp. 829 - 837, 2004.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
21
21
21
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| Cell Constants: |
| a = 49.820 | b = 104.832 | c = 193.539 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 90.00 | (degrees) |
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| Refinement: | The structure was refined using the REFMAC 5.1.24 program.
The R value is
18.8
for 49775 reflections
in the resolution range 50. to
2.20 Ångstroms
with Fobs > 0. sigma(Fobs).
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