 | | | |
| Title: | | CRYSTAL STRUCTURE OF HUMAN TYROSYL-DNA PHOSPHODIESTERASE COMPLEXED WITH VANADATE, OCTOPAMINE, AND TETRANUCLEOTIDE AGTC | |
|
| Molecular Description: |
Tyrosyl-DNA Phosphodiesterase 1 (E.C.3.1.4.-)/DNA complex |
 |
| Structural Features: | SINGLE STRAND |
|
| Nucleic Acid Sequence: |
| | | |
| Chains | D,F: | | (DA) (DG) (DT) (DC) |
|
|
| Protein Sequence: |
|
|
| Primary Citation: | Davies, D.R., Interthal, H., Champoux, J.J., Hol, W.G.
Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes.
J.Med.Chem.
, 47,
pp. 829 - 837, 2004.
|
|
| | | |
| Experimental Information: | X-RAY DIFFRACTION |
|
| Space Group: |
P
21
21
21
|
|
| Cell Constants: |
| a = 49.791 | b = 104.894 | c = 194.124 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 90.00 | (degrees) |
|
|
| Refinement: | The structure was refined using the REFMAC 5.1.24 program.
The R value is
19.4
for 64557 reflections
in the resolution range 50. to
2.00 Ångstroms
with Fobs > 0. sigma(Fobs).
|
|
|
