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| Title: | | STRUCTURAL MECHANISMS OF CAMPTOTHECIN RESISTANCE BY MUTATIONS IN HUMAN TOPOISOMERASE I | |
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| Molecular Description: | DNA topoisomerase I/DNA
(S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLI NE-3,14(4H,12H)-DIONE |
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| Structural Features: | B DOUBLE HELIX, BASE INTERCALATED |
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| Nucleic Acid Sequence: |
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| Protein Sequence: |
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| Primary Citation: | Chrencik, J.E., Staker, B.L., Burgin, A.B., Pourquier, P., Pommier, Y., Stewart, L., Redinbo, M.R.
Mechanisms of camptothecin resistance by human topoisomerase I mutations
J.Mol.Biol.
, 339,
pp. 773 - 784, 2004.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
1
21
1
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| Cell Constants: |
| a = 57.333 | b = 115.354 | c = 75.172 | (Ångstroms) |
 = 90.00 |  = 94.33 |  = 90.00 | (degrees) |
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| Refinement: | The structure was refined using the CNS program.
The R value is
24.6
for 56412 reflections
in the resolution range 43.69 to
2.3 Ångstroms
with I > 0. sigma(I).
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