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| Title: | | HIV-1 REVERSE TRANSCRIPTASE CROSSLINKED TO TENOFOVIR TERMINATED TEMPLATE-PRIMER (COMPLEX P) | |
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| Molecular Description: |
HIV-1 reverse transcriptase(E.C.2.7.7.49)/Fab heavy,light chains/DNA Complex |
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| Structural Features: | B DOUBLE HELIX, OVERHANGING BASES |
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| Nucleic Acid Sequence: |
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| Protein Sequence: |
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| Primary Citation: | Tuske, S., Sarafianos, S.G., Clark Jr., A.D., Ding, J., Naeger, L.K., White, K.L., Miller, M.D., Gibbs, C.S., Boyer, P.L., Clark, P., Wang, G., Gaffney, B.L., Jones, R.A., Jerina, D.M., Hughes, S.H., Arnold, E.
Structure of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir
Nat.Struct.Mol.Biol.
, 11,
pp. 469 - 474, 2004.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
32
1
2
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| Cell Constants: |
| a = 166.780 | b = 166.780 | c = 221.130 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 120.00 | (degrees) |
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| Refinement: | The structure was refined using the CNS 1.0 program.
The R value is
25.6
for 59819 reflections
in the resolution range 20. to
3.1 Ångstroms
with Fobs > 1.1 sigma(Fobs).
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