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| Title: | | HIV-1 REVERSE TRANSCRIPTASE CROSSLINKED TO TEMPLATE-PRIMER WITH TENOFOVIR-DIPHOSPHATE BOUND AS THE INCOMING NUCLEOTIDE SUBSTRATE | |
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| Molecular Description: | HIV-1 reverse transcriptase p51
p66 subunit/DNA Complex |
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| Structural Features: | B DOUBLE HELIX, OVERHANGING BASES |
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| Nucleic Acid Sequence: |
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| Protein Sequence: |
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| Primary Citation: | Tuske, S., Sarafianos, S.G., Clark Jr., A.D., Ding, J., Naeger, L.K., White, K.L., Miller, M.D., Gibbs, C.S., Boyer, P.L., Clark, P., Wang, G., Gaffney, B.L., Jones, R.A., Jerina, D.M., Hughes, S.H., Arnold, E.
Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir
Nat.Struct.Mol.Biol.
, 11,
pp. 469 - 474, 2004.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
31
1
2
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| Cell Constants: |
| a = 171.570 | b = 171.570 | c = 156.270 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 120.00 | (degrees) |
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| Refinement: | The structure was refined using the CNS 1.0 program.
The R value is
25.3
for 42950 reflections
in the resolution range 20.0 to
3.0 Ångstroms
with Fobs > 1.1 sigma(Fobs).
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