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| Title: | | HUMAN DNA TOPOISOMERASE I (70 KDA) IN COMPLEX WITH THE POISON CAMPTOTHECIN AND COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX | |
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| Molecular Description: | DNA Topoisomerase I/ 5'-D(ApApApApApGpAp
CpTpT)-3' |
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| Structural Features: | B DOUBLE HELIX, BASE INTERCALATED |
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| Nucleic Acid Sequence: |
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| Protein Sequence: |
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| Primary Citation: | Staker, B.L., Feese, M.D., Cushman, M., Pommier, Y., Zembower, D., Stewart, L., Burgin, A.B.
Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex
J.Med.Chem.
, 48,
pp. 2336 - 2345, 2005.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
1
21
1
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| Cell Constants: |
| a = 57.363 | b = 114.423 | c = 74.118 | (Ångstroms) |
 = 90.00 |  = 93.49 |  = 90.00 | (degrees) |
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| Refinement: | The structure was refined using the REFMAC 5 program.
The R value is
24.1
for 16492 reflections
in the resolution range 20.00 to
3.00 Ångstroms
. |
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