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| Title: | | STRUCTURE OF A HIGH-FIDELITY POLYMERASE BOUND TO A BENZO[A]PYRENE ADDUCT THAT BLOCKS REPLICATION | |
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| Molecular Description: |
DNA polymerase I (E.C.2.7.7.7)/DNA Complex |
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| Structural Features: | B DOUBLE HELIX |
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| Nucleic Acid Sequence: |
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| Chain | B: | | (DG) (DG) (DG) (DA) (DT) (DG) (DG) (DT) (DG) (DC) |
| Chain | C: | | (DA) (DC) (DT) (DC) (DG) (DC) (DA) (DC) (DC) (DA) (DT) (DC) (DC) (DC) (DT) |
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| Protein Sequence: |
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| Primary Citation: | Hsu, G.W., Huang, X., Luneva, N.P., Geacintov, N.E., Beese, L.S.
Structure of a High Fidelity DNA Polymerase Bound to a Benzo[a]pyrene Adduct That Blocks Replication
J.Biol.Chem.
, 280,
pp. 3764 - 3770, 2005.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
21
21
21
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| Cell Constants: |
| a = 88.752 | b = 93.733 | c = 104.512 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 90.00 | (degrees) |
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| Refinement: | The structure was refined using the CNS 1.0 program.
The R value is
22.1
for 67114 reflections
in the resolution range 42.76 to
1.90 Ångstroms
with Fobs > 0.0 sigma(Fobs).
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