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| Title: | | STRUCTURE OF VARIOLA TOPOISOMERASE COVALENTLY BOUND TO DNA | |
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| Molecular Description: |
DNA topoisomerase 1 (E.C.5.99.1.2)/DNA Complex |
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| Structural Features: | B DOUBLE HELIX, OVERHANGING BASES |
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| Nucleic Acid Sequence: |
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| Chain | Y: | | (DT) (DT) (DG) (DT) (DC) (DG) (DC) (DC) (DC) (DT) (DT) |
| Chain | Z: | | (DT) (DA) (DA) (DT) (DA) (DA) (DG) (DG) (DG) (DC) (DG) (DA) (DC) (DA) |
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| Protein Sequence: |
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| Primary Citation: | Perry, K., Hwang, Y., Bushman, F.D., Van Duyne, G.D.
Structural basis for specificity in the poxvirus topoisomerase.
Mol.Cell
, 23,
pp. 343 - 354, 2006.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
C
2
2
21
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| Cell Constants: |
| a = 68.523 | b = 138.232 | c = 113.079 | (Ångstroms) |
 = 90.000 |  = 90.000 |  = 90.000 | (degrees) |
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| Refinement: | The structure was refined using the REFMAC 5.2.0005 program.
The R value is
19.1
for 15090 reflections
in the resolution range 50.0 to
2.700 Ångstroms
with Fobs > 0.00 sigma(Fobs).
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