1 126 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 GACACUAAGU UCGGCAUCAA UAUGGUGACC UCCCGGGAGC GGGGGACCAC CAGGUUGCCU AGAGGGGUGA ACCGGCCCAG GUCGGAAACG GAGCAGGUCA AAACUCCCGU GCUGAUCAGU AGUGUc 126 CCC LOOP1 36 39 LOOP2 85 88 Crystallography ? ? Angstroms 1 G O3' 69.816 35.695 -73.292 2 A P 70.050 37.266 -73.525 O3' 69.502 39.612 -77.908 3 C P 69.576 41.167 -77.528 O3' 67.401 44.632 -80.430 4 A P 67.380 46.162 -79.938 O3' 62.748 49.741 -80.025 5 C P 63.712 51.025 -79.900 O3' 60.287 54.434 -76.962 6 U P 61.026 55.561 -76.090 O3' 59.104 57.400 -71.789 7 A P 60.124 58.614 -72.071 O3' 62.577 59.953 -67.824 8 A P 63.797 60.994 -67.887 O3' 68.123 60.257 -64.091 9 G P 69.681 60.602 -64.280 O3' 73.555 58.346 -62.313 10 U P 74.288 59.715 -62.729 O3' 78.995 59.774 -64.624 11 U P 79.627 61.225 -64.816 O3' 83.513 61.427 -68.051 12 C P 83.806 62.996 -68.178 O3' 84.238 66.750 -72.431 13 G P 83.839 68.265 -72.750 O3' 81.817 70.899 -77.268 14 G P 81.248 72.402 -77.250 O3' 78.257 74.188 -80.158 15 C P 78.124 75.586 -79.404 O3' 73.123 78.468 -78.908 16 A P 72.906 79.733 -77.956 O3' 68.284 81.187 -76.579 17 U P 68.721 82.609 -75.961 O3' 66.562 82.942 -70.666 18 C P 66.167 84.498 -70.792 O3' 62.376 86.068 -74.210 19 A P 61.840 87.510 -74.695 O3' 58.127 88.158 -78.338 20 A P 57.463 89.623 -78.475 O3' 53.208 91.584 -78.608 21 U P 53.148 93.164 -78.324 O3' 49.346 96.133 -75.124 22 A P 49.710 97.692 -75.189 O3' 47.944 101.034 -71.657 23 U P 48.331 102.576 -71.422 O3' 49.386 105.518 -66.536 24 G P 50.361 106.688 -67.029 O3' 53.857 108.833 -63.827 25 G P 54.847 109.932 -64.455 O3' 59.588 111.231 -63.552 26 U P 59.879 112.349 -64.658 O3' 64.673 113.021 -66.356 27 G P 64.558 114.223 -67.410 O3' 67.400 114.540 -71.375 28 A P 67.071 115.628 -72.491 O3' 68.955 115.952 -77.683 29 C P 68.385 117.416 -77.989 O3' 66.649 118.069 -82.831 30 C P 66.090 119.553 -82.584 O3' 61.542 120.582 -85.037 31 U P 61.346 122.143 -84.662 O3' 56.180 123.566 -84.224 32 C P 56.246 125.141 -84.001 O3' 52.917 127.933 -80.896 33 C P 53.515 129.399 -80.569 O3' 51.177 131.525 -76.182 34 C P 51.621 132.970 -75.624 O3' 52.267 134.848 -71.241 35 G P 53.064 136.221 -71.445 O3' 56.775 137.984 -68.313 36 G P 57.353 139.261 -69.072 O3' 62.361 140.893 -67.939 37 G P 61.796 142.341 -68.335 O3' 65.153 142.073 -73.052 38 A P 65.369 141.053 -74.260 O3' 69.113 137.106 -75.678 39 G P 68.593 135.604 -75.517 O3' 71.860 131.691 -74.557 40 C P 70.811 130.488 -74.488 O3' 68.390 129.039 -69.301 41 G P 67.363 127.858 -68.912 O3' 63.931 127.599 -65.204 42 G P 63.470 126.109 -65.589 O3' 58.615 124.871 -64.931 43 G P 58.303 123.367 -65.409 O3' 53.918 121.354 -67.294 44 G P 54.085 119.943 -68.071 O3' 50.698 118.342 -71.739 45 G P 50.992 116.942 -72.488 O3' 50.090 115.266 -76.906 46 A P 50.340 113.718 -76.581 O3' 52.213 111.018 -80.789 47 C P 52.299 109.518 -80.215 O3' 56.615 107.010 -82.346 48 C P 56.604 105.542 -81.665 O3' 61.316 103.403 -81.150 49 A P 61.582 102.176 -80.159 O3' 65.573 101.195 -76.266 50 C P 65.094 99.918 -75.447 O3' 67.201 100.093 -70.590 51 C P 66.565 98.938 -69.669 O3' 66.242 99.221 -64.721 52 A P 65.420 98.011 -64.053 O3' 60.839 98.033 -60.540 53 G P 60.473 96.458 -60.582 O3' 54.918 95.948 -60.578 54 G P 54.422 94.475 -60.114 O3' 49.570 92.312 -60.982 55 U P 49.471 90.766 -61.420 O3' 46.231 88.683 -64.893 56 U P 46.491 87.113 -65.143 O3' 45.883 84.913 -69.743 57 G P 45.985 83.332 -69.520 O3' 48.519 79.464 -72.920 58 C P 49.359 78.101 -72.823 O3' 53.306 75.940 -76.525 59 C P 54.815 75.374 -76.454 O3' 58.894 75.882 -80.640 60 U P 60.484 75.818 -80.887 O3' 60.894 72.529 -76.674 61 A P 59.930 73.652 -76.057 O3' 61.728 75.593 -70.919 62 G P 54.125 83.672 -60.560 O3' 58.450 87.657 -60.614 63 A P 59.589 86.764 -59.918 O3' 63.795 87.066 -61.583 64 G P 64.821 88.080 -62.301 O3' 69.848 88.100 -60.124 65 G P 70.885 89.317 -60.234 O3' 75.712 89.440 -58.975 66 G P 76.174 90.920 -59.381 O3' 80.989 92.512 -61.821 67 G P 81.093 93.975 -62.472 O3' 84.973 94.324 -65.956 68 U P 84.870 95.867 -66.367 O3' 87.411 97.022 -70.938 69 G P 87.570 98.585 -70.568 O3' 88.518 99.186 -76.163 70 A P 88.134 99.218 -77.741 O3' 84.702 101.011 -80.941 71 A P 84.705 99.581 -81.718 O3' 82.089 103.658 -83.640 72 C P 81.821 104.996 -82.790 O3' 77.596 107.975 -83.799 73 C P 77.697 109.103 -82.662 O3' 73.599 111.330 -80.470 74 G P 74.330 112.249 -79.367 O3' 71.810 113.223 -74.785 75 G P 72.609 114.277 -73.866 O3' 72.131 114.712 -69.214 76 C P 72.911 116.064 -68.791 O3' 75.645 116.718 -64.629 77 C P 76.143 118.220 -64.897 O3' 80.802 119.122 -62.672 78 C P 80.836 120.704 -62.916 O3' 85.801 122.060 -64.921 79 A P 85.606 123.652 -65.033 O3' 89.337 125.383 -67.999 80 G P 89.029 126.887 -68.501 O3' 91.919 128.986 -72.387 81 G P 91.031 130.333 -72.507 O3' 89.946 131.891 -77.372 82 U P 89.222 133.324 -77.203 O3' 85.003 134.244 -79.813 83 C P 84.577 135.693 -79.275 O3' 79.505 137.081 -79.402 84 G P 79.133 138.428 -78.611 O3' 75.701 140.316 -75.721 85 G P 76.604 141.573 -75.300 O3' 76.420 143.431 -70.535 86 A P 77.480 144.597 -70.865 O3' 81.628 143.190 -67.826 87 A P 81.810 141.600 -67.979 O3' 82.358 139.111 -63.345 88 A P 82.342 137.546 -63.013 O3' 78.725 134.303 -59.974 89 C P 79.423 132.912 -60.349 O3' 75.663 130.467 -63.855 90 G P 75.679 129.078 -64.650 O3' 72.887 128.253 -68.889 91 G P 73.354 126.999 -69.786 O3' 73.143 126.301 -74.626 92 A P 73.558 124.844 -75.175 O3' 74.845 123.703 -79.743 93 G P 74.955 122.104 -79.658 O3' 79.627 119.475 -81.197 94 C P 80.020 117.996 -80.761 O3' 85.293 116.491 -79.840 95 A P 85.445 115.093 -79.025 O3' 90.013 113.956 -76.881 96 G P 89.590 112.658 -76.033 O3' 90.456 111.507 -71.218 97 G P 89.779 110.067 -71.449 O3' 87.851 108.724 -66.518 98 U P 87.243 107.259 -66.790 O3' 82.760 106.034 -64.593 99 C P 82.337 104.589 -65.189 O3' 77.233 103.651 -64.566 100 A P 76.996 102.196 -65.215 O3' 72.235 101.490 -67.528 101 A P 72.380 99.961 -67.974 O3' 70.058 99.289 -72.820 102 A P 70.128 97.753 -73.264 O3' 71.121 96.189 -77.474 103 A P 71.470 94.626 -77.493 O3' 75.470 92.123 -79.998 104 C P 75.201 90.596 -79.562 O3' 79.843 87.896 -78.887 105 U P 79.945 86.488 -78.145 O3' 82.666 84.448 -73.669 106 C P 81.991 83.037 -73.330 O3' 82.999 81.208 -68.703 107 C P 81.886 80.063 -68.533 O3' 81.062 79.101 -63.625 108 C P 80.254 77.721 -63.653 O3' 76.516 76.233 -60.665 109 G P 75.707 74.965 -61.250 O3' 70.558 74.393 -60.713 110 U P 70.377 72.977 -61.453 O3' 65.935 71.994 -63.789 111 G P 66.017 70.612 -64.598 O3' 64.516 69.655 -69.966 112 C P 64.763 68.275 -70.735 O3' 64.520 67.977 -75.746 113 U P 64.920 66.481 -76.165 O3' 68.055 65.457 -80.412 114 G P 68.726 63.995 -80.487 O3' 72.871 62.127 -82.318 115 A P 72.810 60.601 -81.815 O3' 77.455 57.914 -81.055 116 U P 77.336 56.421 -80.463 O3' 80.782 54.713 -77.013 117 C P 80.381 53.196 -77.358 O3' 80.251 51.052 -72.814 118 A P 79.707 49.576 -73.163 O3' 77.197 46.775 -68.721 119 G P 76.425 45.438 -69.172 O3' 70.989 45.310 -67.373 120 U P 69.423 45.027 -67.608 O3' 66.951 45.197 -62.319 121 A P 66.114 45.771 -61.067 O3' 61.075 47.919 -62.419 122 G P 60.508 46.467 -62.797 O3' 55.869 46.550 -65.483 123 U P 55.669 45.007 -65.896 O3' 52.084 45.075 -69.978 124 G P 51.959 43.824 -70.987 O3' 53.014 43.408 -76.598 125 U P 52.748 41.878 -76.999 O3' 54.969 40.086 -80.769 126 c P 54.229 38.669 -80.605 O3' 57.205 34.779 -82.807 70 syn 71 syn 75 syn 102 syn 1 126 + + c 2 125 - - c 3 124 + + c 4 123 - - c 5 122 + + c 6 121 - - c 7 120 W H c 9 117 + + c 10 116 W W c 11 115 - - c 12 114 + + c 13 113 W W c 14 112 + + c 15 111 + + c 16 110 - - c 17 109 W W c 18 57 + + c 19 56 - - c 20 55 - - c 21 53 W W c 21 54 W W c 22 53 H S t 23 52 - - c 24 51 + + c 25 50 + + c 26 49 - - c 27 48 + + c 28 47 W W c 29 46 W W c 30 45 + + c 31 44 W W c 32 43 + + c 33 42 + + c 34 41 + + c 35 40 + + c 38 88 W W t 39 84 S S c 39 88 W W t 39 89 S S t 57 58 S H c 61 111 S S c 64 107 + + c 65 106 + + c 66 105 W W c 67 104 + + c 68 103 - - c 72 102 W H c 74 99 + + c 76 97 + + c 77 96 + + c 79 94 H W t 80 93 W W c 81 92 W W c 82 91 W W c 83 90 + + c 84 89 + + c 85 88 S H t 8 120 ! ! ! 16 109 ! ! ! 19 58 ! ! ! 37 87 ! ! ! 69 101 ! ! ! 69 102 ! ! ! 75 98 ! ! ! 78 95 ! ! ! 39 90 ! ! ! 40 91 ! ! ! 12 13 ! ! ! 21 22 ! ! ! 36 39 ! ! ! 38 84 ! ! ! 53 54 ! ! ! 119 120 ! ! ! 1 126 7 9 117 9 64 107 5 18 57 18 74 99 11 SG1 8 8 SG2 36 39 SG3 58 63 SG4 69 73 SG5 85 88 SG6 100 102 SG7 108 108 SG8 118 119 1 68.307 0.000 2 74.950 12.502 3 81.593 25.003 4 88.236 37.505 5 94.880 50.007 6 101.523 62.508 7 108.166 75.010 8 112.152 82.511 9 131.755 110.153 10 131.530 124.308 11 131.305 138.463 12 131.081 152.619 13 130.856 166.774 14 130.631 180.930 15 130.407 195.085 16 130.182 209.240 17 129.958 223.396 18 35.892 249.427 19 35.892 263.584 20 35.892 277.741 21 35.892 291.898 22 35.892 306.055 23 35.892 320.212 24 35.892 334.370 25 35.892 348.527 26 35.892 362.684 27 35.892 376.841 28 35.892 390.998 29 35.892 405.155 30 35.892 419.312 31 35.892 433.470 32 35.892 447.627 33 35.892 461.784 34 35.892 475.941 35 35.892 490.098 36 37.806 506.223 37 27.022 518.363 38 10.784 518.363 39 0.000 506.223 40 1.915 490.098 41 1.915 475.941 42 1.915 461.784 43 1.915 447.627 44 1.915 433.470 45 1.915 419.312 46 1.915 405.155 47 1.915 390.998 48 1.915 376.841 49 1.915 362.684 50 1.915 348.527 51 1.915 334.370 52 1.915 320.212 53 1.915 306.055 54 1.915 291.898 55 1.915 277.741 56 1.915 263.584 57 1.915 249.427 58 180.468 252.515 59 171.974 252.380 60 163.481 252.246 61 154.988 252.111 62 146.495 251.976 63 138.001 251.841 64 129.508 251.706 65 129.284 265.862 66 129.059 280.017 67 128.834 294.173 68 128.610 308.328 69 128.475 316.821 70 128.340 325.314 71 128.205 333.808 72 128.071 342.301 73 127.936 350.794 74 120.806 378.880 75 119.875 393.006 76 118.944 407.133 77 118.013 421.259 78 117.082 435.386 79 116.150 449.512 80 115.219 463.639 81 114.288 477.765 82 113.357 491.892 83 112.426 506.018 84 111.495 520.145 85 108.524 536.109 86 118.486 548.932 87 134.689 550.000 88 146.248 538.595 89 145.398 522.380 90 146.329 508.253 91 147.261 494.127 92 148.192 480.000 93 149.123 465.874 94 150.054 451.747 95 150.985 437.621 96 151.916 423.494 97 152.848 409.368 98 153.779 395.241 99 154.710 381.115 100 94.232 333.268 101 94.367 324.775 102 94.502 316.282 103 94.637 307.789 104 94.861 293.633 105 95.086 279.478 106 95.311 265.323 107 95.535 251.167 108 87.491 222.722 109 95.985 222.857 110 96.209 208.701 111 96.434 194.546 112 96.659 180.390 113 96.883 166.235 114 97.108 152.080 115 97.332 137.924 116 97.557 123.769 117 97.782 109.614 118 86.134 105.956 119 82.148 98.455 120 78.162 90.954 121 71.519 78.452 122 64.876 65.951 123 58.232 53.449 124 51.589 40.947 125 44.946 28.446 126 38.302 15.944