1 128 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 GACACUAAGU UCGGCAUCAA UAUGGUGACC UCCCGGGAGC GGGGGACCAC CAGGUUGCCU AAGGAGGGGU GAACCGGCCC AGGUCGGAAA CGGAGCAGGU CAAAACUCCC GUGCUGAUCA GUAGUGUc 128 CCC LOOP1 87 90 LOOP2 36 39 Crystallography ? ? Angstroms 1 G O3' 36.240 19.677 60.350 2 A P 35.808 21.011 59.567 O3' 35.281 21.867 54.827 3 C P 34.578 23.267 54.482 O3' 30.218 24.217 50.831 4 A P 29.369 25.569 50.808 O3' 23.658 26.369 49.949 5 C P 23.400 27.948 49.966 O3' 18.699 29.716 51.737 6 U P 18.842 31.305 51.961 O3' 16.036 33.808 55.632 7 A P 16.642 35.280 55.864 O3' 16.722 37.629 60.425 8 A P 17.382 38.997 59.891 O3' 21.447 40.936 62.459 9 G P 22.125 42.298 61.939 O3' 26.632 43.864 63.317 10 U P 26.932 45.208 62.491 O3' 31.075 47.405 61.483 11 U P 30.453 48.742 60.834 O3' 33.739 50.958 57.335 12 C P 32.936 52.292 56.938 O3' 34.318 54.335 52.151 13 G P 33.367 55.410 51.429 O3' 30.117 55.565 46.781 14 G P 28.873 56.551 46.562 O3' 25.484 56.050 42.862 15 C P 24.537 57.338 43.015 O3' 19.561 56.930 41.648 16 A P 19.064 58.434 41.913 O3' 14.112 58.703 44.223 17 U P 13.553 60.188 44.548 O3' 10.915 61.403 48.239 18 C P 10.362 62.800 48.811 O3' 5.460 64.533 47.537 19 A P 4.774 65.980 47.663 O3' -0.254 66.759 47.418 20 A P -0.387 68.331 47.717 O3' -5.095 69.577 49.941 21 U P -5.310 70.969 50.711 O3' -6.931 72.633 55.908 22 A P -6.614 74.199 56.035 O3' -8.076 76.176 60.645 23 U P -7.649 77.717 60.781 O3' -5.568 80.044 64.577 24 G P -5.062 81.423 63.925 O3' -0.937 83.714 65.820 25 G P -0.361 84.962 64.990 O3' 4.810 86.354 63.326 26 U P 4.684 87.742 62.538 O3' 8.369 88.790 59.341 27 G P 7.783 90.053 58.532 O3' 9.149 90.483 53.420 28 A P 8.485 91.831 52.848 O3' 7.076 91.936 47.806 29 C P 6.394 93.336 47.473 O3' 2.280 93.879 44.297 30 C P 1.573 95.312 44.487 O3' -3.519 95.468 43.038 31 U P -4.095 96.957 43.221 O3' -8.525 97.979 44.609 32 C P -8.912 99.462 45.073 O3' -12.594 101.463 48.875 33 C P -12.372 103.024 48.668 O3' -12.808 105.861 53.373 34 C P -12.363 107.409 53.341 O3' -11.702 110.003 57.530 35 G P -11.030 111.380 57.048 O3' -7.660 113.978 59.621 36 G P -7.657 115.135 58.508 O3' -2.922 117.359 58.019 37 G P -3.370 118.426 56.913 O3' -0.320 117.514 52.849 38 A P -0.018 115.958 52.666 O3' 4.811 112.884 52.142 39 G P 4.643 111.310 52.400 O3' 8.103 108.002 54.118 40 C P 7.208 106.702 54.458 O3' 4.654 105.994 59.554 41 G P 3.978 104.641 60.083 O3' 0.798 104.432 63.849 42 G P 0.458 102.871 63.698 O3' -4.526 101.309 64.463 43 G P -4.399 99.709 64.318 O3' -8.375 96.836 62.309 44 G P -8.187 95.386 61.636 O3' -10.998 92.767 59.021 45 G P -10.509 91.325 58.496 O3' -11.339 88.599 53.456 46 A P -10.446 87.269 53.515 O3' -8.847 84.995 49.331 47 C P -7.989 83.712 49.785 O3' -4.388 82.102 46.344 48 C P -3.763 80.804 47.060 O3' 1.243 79.523 46.229 49 A P 1.732 78.327 47.193 O3' 6.386 77.588 48.696 50 C P 6.235 76.328 49.676 O3' 9.705 76.296 53.695 51 C P 9.428 75.122 54.758 O3' 10.783 75.349 59.865 52 A P 10.456 74.044 60.738 O3' 9.327 73.595 65.826 53 G P 10.018 72.155 65.651 O3' 5.873 68.869 68.106 54 G P 5.125 67.529 67.625 O3' 0.622 66.122 67.375 55 U P 0.393 64.698 66.661 O3' -4.058 62.385 63.814 56 U P -3.770 60.884 63.317 O3' -7.080 59.980 59.064 57 G P -7.034 58.550 58.324 O3' -7.894 59.236 52.653 58 C P -7.717 58.863 51.097 O3' -5.602 54.186 50.056 59 C P -5.585 55.058 48.702 O3' 0.068 55.003 48.081 60 U P -0.233 53.584 47.396 O3' 5.083 51.373 46.599 61 A P 4.622 49.853 46.332 O3' 6.752 49.200 51.748 62 A P 6.906 50.115 53.057 O3' 9.081 54.415 55.310 63 G P 7.955 55.287 56.052 O3' 8.444 61.066 56.123 64 G P 7.292 62.090 56.570 O3' 7.998 63.463 61.795 65 A P 8.429 64.701 62.726 O3' 10.759 69.082 60.563 66 G P 11.837 69.480 61.681 O3' 15.636 68.719 64.104 67 G P 16.322 70.167 63.964 O3' 21.300 71.123 64.459 68 G P 21.726 72.627 64.067 O3' 25.867 74.610 60.845 69 G P 25.827 76.168 60.487 O3' 28.627 77.353 56.155 70 U P 28.599 78.949 56.335 O3' 28.476 81.387 51.815 71 G P 28.381 82.921 52.283 O3' 24.863 86.171 50.179 72 A P 26.059 87.160 50.614 O3' 27.996 86.862 45.166 73 A P 28.161 87.760 43.846 O3' 26.453 91.394 47.042 74 C P 25.061 90.608 47.163 O3' 20.475 93.216 46.458 75 C P 19.762 91.956 47.173 O3' 16.354 89.215 43.962 76 G P 15.871 87.987 44.875 O3' 14.445 89.095 49.480 77 G P 14.362 90.436 50.397 O3' 12.393 90.882 54.840 78 C P 12.641 92.283 55.589 O3' 14.182 93.459 60.846 79 C P 14.201 95.050 60.654 O3' 17.348 97.400 63.640 80 C P 17.154 98.901 63.119 O3' 21.274 101.921 60.800 81 A P 21.806 103.203 59.996 O3' 25.431 105.790 61.903 82 G P 24.827 107.129 61.279 O3' 27.803 110.010 57.869 83 G P 26.736 111.224 57.800 O3' 25.684 112.570 52.672 84 U P 24.403 113.531 52.578 O3' 20.605 113.146 49.269 85 C P 19.748 114.466 49.582 O3' 14.520 114.354 49.127 86 G P 14.099 115.797 49.674 O3' 10.033 117.229 52.455 87 G P 10.542 118.739 52.739 O3' 9.741 120.551 57.567 88 A P 10.332 121.999 57.163 O3' 15.092 122.018 59.563 89 A P 15.377 120.444 59.781 O3' 16.075 118.579 64.921 90 A P 16.345 117.008 65.104 O3' 14.001 113.880 68.597 91 C P 14.708 112.452 68.354 O3' 11.474 108.697 65.285 92 G P 11.937 107.261 64.740 O3' 9.694 105.354 60.406 93 G P 10.440 104.043 59.857 O3' 10.446 103.009 54.692 94 A P 11.230 101.593 54.574 O3' 13.947 100.524 50.125 95 G P 14.413 99.115 50.744 O3' 19.713 98.548 49.926 96 C P 20.449 97.202 50.456 O3' 25.307 96.562 48.986 97 A P 25.919 95.309 49.773 O3' 30.519 95.390 52.013 98 G P 30.602 93.936 52.702 O3' 31.097 92.457 57.561 99 G P 30.630 90.920 57.684 O3' 28.282 89.051 62.100 100 U P 28.028 87.508 61.719 O3' 23.201 85.841 63.619 101 C P 22.985 84.253 63.496 O3' 18.727 81.656 63.056 102 A P 17.330 82.000 63.817 O3' 14.521 79.018 59.905 103 A P 15.464 79.957 59.008 O3' 12.122 81.657 54.688 104 A P 13.518 81.458 53.913 O3' 11.537 79.978 49.267 105 A P 11.965 78.438 49.170 O3' 15.069 76.834 45.192 106 C P 15.343 75.256 45.392 O3' 19.902 73.434 44.351 107 U P 20.033 71.864 44.660 O3' 24.270 69.385 47.664 108 C P 23.858 67.841 47.811 O3' 26.893 65.320 51.940 109 C P 26.467 63.776 51.879 O3' 26.793 61.700 56.700 110 C P 26.156 60.231 56.487 O3' 23.307 59.046 60.136 111 G P 22.928 57.484 59.989 O3' 17.689 55.432 61.110 112 U P 17.932 53.925 60.598 O3' 13.650 52.196 57.872 113 G P 14.105 50.699 57.471 O3' 13.367 48.595 53.319 114 C P 14.199 47.250 52.990 O3' 16.124 44.992 47.919 115 U P 17.383 43.997 47.833 O3' 21.627 44.539 45.050 116 G P 22.234 43.103 45.437 O3' 27.695 42.449 43.729 117 A P 28.074 41.047 44.421 O3' 32.998 41.349 46.426 118 U P 33.369 40.083 47.347 O3' 36.675 41.006 51.238 119 C P 37.036 39.471 51.543 O3' 37.618 38.291 56.659 120 A P 37.476 36.702 56.864 O3' 35.679 35.615 61.862 121 G P 36.969 34.645 61.815 O3' 33.318 31.020 63.035 122 U P 32.529 29.675 63.420 O3' 29.100 29.737 67.232 123 A P 28.077 29.648 68.478 O3' 23.728 28.824 68.355 124 G P 23.497 27.235 68.286 O3' 18.974 24.295 66.055 125 U P 19.314 22.763 65.701 O3' 16.859 20.484 61.615 126 G P 17.459 19.022 61.313 O3' 18.220 16.897 56.737 127 U P 18.983 15.496 56.954 O3' 21.712 13.839 52.677 128 c P 22.034 12.287 52.935 O3' 26.737 9.867 52.108 65 syn 1 128 + + c 2 127 - - c 3 126 + + c 4 125 - - c 5 124 + + c 6 123 - - c 7 122 W H t 8 120 W W c 9 119 + + c 10 118 W W c 11 117 - - c 12 116 + + c 13 115 W W c 14 114 + + c 15 113 + + c 16 112 - - c 17 111 W W c 18 57 W W c 19 56 W W c 20 55 - - c 21 54 W W c 22 53 W W c 24 51 + + c 25 50 + + c 25 103 S S t 26 49 - - c 27 48 + + c 28 47 W W c 29 46 W W c 30 45 + + c 31 44 W W c 32 43 + + c 33 42 + + c 34 41 + + c 35 40 + + c 38 90 W W t 39 86 S S c 39 91 S S t 64 110 + + c 66 109 + + c 67 108 + + c 68 107 W W c 69 106 + + c 70 105 - - c 71 104 S H t 76 101 + + c 77 100 W W c 78 99 + + c 79 98 + + c 80 96 W H t 80 97 S H t 81 96 H W t 82 95 H S t 83 94 W W c 84 93 W W c 85 92 + + c 86 91 + + c 87 90 S H t 39 90 ! ! ! 16 62 ! ! ! 17 63 ! ! ! 39 92 ! ! ! 40 93 ! ! ! 59 63 ! ! ! 101 103 ! ! ! 36 39 ! ! ! 38 86 ! ! ! 50 103 ! ! ! 51 102 ! ! ! 55 65 ! ! ! 58 59 ! ! ! 72 76 ! ! ! 80 81 ! ! ! 103 104 ! ! ! 121 122 ! ! ! 1 128 7 8 120 10 66 109 6 76 101 5 82 95 5 18 57 5 24 51 12 SG1 23 23 SG2 36 39 SG3 52 52 SG4 58 65 SG5 72 75 SG6 81 81 SG7 87 90 SG8 96 96 SG9 102 103 SG10 110 110 SG11 121 121 1 131.944 0.000 2 131.944 12.501 3 131.944 25.002 4 131.944 37.503 5 131.944 50.004 6 131.944 62.505 7 131.944 75.006 8 131.944 100.008 9 131.944 112.509 10 131.944 125.010 11 131.944 137.511 12 131.944 150.012 13 131.944 162.513 14 131.944 175.014 15 131.944 187.515 16 131.944 200.016 17 131.944 212.517 18 32.088 281.175 19 32.068 293.676 20 32.047 306.177 21 32.026 318.678 22 32.006 331.179 23 31.985 343.680 24 31.944 368.682 25 31.923 381.183 26 31.902 393.684 27 31.882 406.185 28 31.861 418.686 29 31.840 431.187 30 31.820 443.688 31 31.799 456.189 32 31.778 468.690 33 31.758 481.191 34 31.737 493.692 35 31.716 506.193 36 33.383 520.434 37 23.843 531.138 38 9.505 531.114 39 0.000 520.379 40 1.714 506.143 41 1.735 493.642 42 1.755 481.141 43 1.776 468.640 44 1.797 456.139 45 1.817 443.638 46 1.838 431.137 47 1.859 418.636 48 1.879 406.135 49 1.900 393.634 50 1.921 381.133 51 1.941 368.632 52 1.962 356.131 53 2.003 331.129 54 2.024 318.628 55 2.045 306.127 56 2.065 293.626 57 2.086 281.125 58 191.949 237.519 59 184.449 237.519 60 176.948 237.519 61 169.447 237.519 62 161.947 237.519 63 154.446 237.519 64 146.946 237.519 65 139.445 237.519 66 131.944 237.519 67 131.944 250.020 68 131.944 262.521 69 131.944 275.022 70 131.944 287.523 71 131.944 300.024 72 131.944 312.525 73 131.944 337.527 74 131.944 362.529 75 131.944 375.030 76 131.944 387.531 77 131.944 400.032 78 131.944 412.533 79 131.944 425.034 80 131.944 437.535 81 131.944 450.036 82 131.944 475.038 83 131.944 487.539 84 131.944 500.040 85 131.944 512.541 86 131.944 525.042 87 133.635 539.280 88 124.112 550.000 89 109.774 550.000 90 100.251 539.280 91 101.942 525.042 92 101.942 512.541 93 101.942 500.040 94 101.942 487.539 95 101.942 475.038 96 101.942 462.537 97 101.942 437.535 98 101.942 425.034 99 101.942 412.533 100 101.942 400.032 101 101.942 387.531 102 101.942 350.028 103 101.942 325.026 104 101.942 300.024 105 101.942 287.523 106 101.942 275.022 107 101.942 262.521 108 101.942 250.020 109 101.942 237.519 110 94.441 212.517 111 101.942 212.517 112 101.942 200.016 113 101.942 187.515 114 101.942 175.014 115 101.942 162.513 116 101.942 150.012 117 101.942 137.511 118 101.942 125.010 119 101.942 112.509 120 101.942 100.008 121 101.942 87.507 122 101.942 75.006 123 101.942 62.505 124 101.942 50.004 125 101.942 37.503 126 101.942 25.002 127 101.942 12.501 128 101.942 0.000