1 197 1 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 1001 1002 1003 1004 1005 1006 1007 1008 1009 1010 1011 1012 1013 1014 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 gGCCGUGUGC CUUGCGCCGG GAAACCACGC AAGGGAUGGU GUCAAAUUCG GCGAAACCUA AGCGCCCGCC CGGGCGUAUG GCAACGCCGA GCCAAGCUUC GCAGCCAUUG CACUCCGGCU GCGAUGAAGG UGUAGAGACU AGACGGCACC CACCUAAGGC AAACGCUAUG GUGAAGGCAU AGUCCAGGGA GUGGCGa 1 GTP 197 A23 LOOP1 22 23 LOOP2 68 71 LOOP3 107 116 LOOP4 161 164 Crystallography ? ? Angstroms 1 g O3' 58.035 99.066 -24.298 2 G P 58.236 100.459 -25.041 O3' 61.608 104.928 -24.523 3 C P 60.410 105.406 -25.536 O3' 64.163 109.136 -27.554 4 C P 63.605 109.852 -28.865 O3' 66.502 111.531 -32.293 5 G P 65.530 112.059 -33.457 O3' 66.765 111.228 -39.033 6 U P 65.588 111.568 -40.055 O3' 65.215 109.644 -44.595 7 G P 63.877 110.448 -44.918 O3' 60.915 107.929 -48.721 8 U P 59.604 108.816 -48.951 O3' 54.833 106.547 -49.859 9 G P 53.887 107.829 -49.661 O3' 49.053 106.693 -47.640 10 C P 48.315 108.097 -47.844 O3' 45.094 109.515 -44.092 11 C P 44.489 110.672 -45.019 O3' 42.460 114.314 -41.518 12 U P 42.185 115.750 -42.167 O3' 43.066 120.219 -39.504 13 U P 42.620 121.298 -40.601 O3' 45.437 125.643 -41.318 14 G P 44.524 126.183 -42.524 O3' 47.570 129.356 -45.673 15 C P 46.660 129.725 -46.948 O3' 48.554 129.979 -51.669 16 G P 47.219 129.929 -52.557 O3' 47.878 128.152 -57.675 17 C P 46.501 128.500 -58.415 O3' 44.112 125.360 -61.676 18 C P 42.649 125.865 -62.081 O3' 39.472 123.546 -64.214 19 G P 38.466 123.467 -62.968 O3' 35.278 118.817 -63.156 20 G P 33.822 119.357 -62.777 O3' 30.287 116.665 -60.767 21 G P 29.228 117.864 -60.660 O3' 26.138 118.741 -56.719 22 A P 25.399 119.948 -57.480 O3' 26.842 124.601 -54.961 23 A P 28.368 124.346 -54.523 O3' 29.705 125.674 -49.392 24 A P 31.173 125.233 -48.952 O3' 32.426 122.126 -44.507 25 C P 33.978 122.032 -44.871 O3' 35.433 116.783 -45.807 26 C P 36.847 116.338 -46.413 O3' 37.968 112.431 -50.113 27 A P 39.559 112.528 -50.013 O3' 41.633 111.891 -54.616 28 C P 43.078 111.837 -53.933 O3' 46.959 113.637 -56.776 29 G P 48.144 113.414 -55.726 O3' 52.397 115.973 -56.189 30 C P 53.048 115.109 -55.011 O3' 56.384 118.413 -51.970 31 A P 57.081 117.562 -50.814 O3' 58.898 120.339 -46.889 32 A P 59.111 119.159 -45.835 O3' 58.839 120.562 -40.761 33 G P 58.942 119.351 -39.715 O3' 56.779 118.423 -35.215 34 G P 56.667 117.216 -34.161 O3' 52.690 114.663 -31.354 35 G P 51.482 113.881 -30.659 O3' 47.503 114.992 -28.733 36 A P 46.904 113.596 -29.226 O3' 41.965 112.749 -29.644 37 U P 42.033 111.167 -29.860 O3' 38.055 109.034 -33.459 38 G P 37.464 107.589 -33.140 O3' 34.855 106.433 -29.387 39 G P 34.528 104.866 -29.502 O3' 30.602 102.380 -27.035 40 U P 30.804 100.820 -27.324 O3' 26.819 97.441 -27.214 41 G P 27.480 96.023 -27.551 O3' 24.566 92.603 -30.545 42 U P 25.378 91.287 -30.950 O3' 24.941 88.754 -35.376 43 C P 26.078 87.637 -35.502 O3' 27.710 85.420 -39.704 44 A P 28.263 84.170 -38.872 O3' 33.222 82.641 -40.733 45 A P 33.801 81.231 -40.473 O3' 33.685 79.956 -45.760 46 A P 35.113 79.261 -45.913 O3' 36.923 80.130 -50.861 47 U P 38.350 79.414 -50.906 O3' 43.396 82.223 -49.742 48 U P 44.554 81.248 -50.269 O3' 45.678 78.634 -54.470 49 C P 47.105 79.153 -54.963 O3' 48.515 78.909 -59.793 50 G P 49.961 79.548 -59.555 O3' 52.194 83.827 -62.674 51 G P 53.472 84.627 -62.135 O3' 54.448 89.191 -64.300 52 C P 55.683 89.817 -63.498 O3' 56.267 94.853 -64.083 53 G P 57.626 95.188 -63.299 O3' 58.426 99.061 -61.180 54 A P 59.756 99.457 -60.387 O3' 60.959 102.040 -55.717 55 A P 62.537 101.927 -55.769 O3' 64.315 105.525 -52.298 56 A P 65.863 105.130 -52.185 O3' 67.861 105.481 -46.922 57 C P 69.406 105.108 -47.102 O3' 71.554 100.907 -44.796 58 C P 72.910 100.670 -45.603 O3' 75.358 96.475 -46.345 59 U P 76.694 97.132 -46.957 O3' 79.308 94.563 -50.637 60 A P 80.614 95.409 -51.010 O3' 81.357 94.357 -57.053 61 A P 82.735 93.625 -57.450 O3' 82.908 91.772 -62.558 62 G P 83.991 92.759 -63.181 O3' 82.884 95.457 -67.598 63 C P 84.113 96.442 -67.864 O3' 83.790 101.430 -68.900 64 G P 85.266 102.040 -68.835 O3' 86.351 106.753 -67.449 65 C P 87.936 106.604 -67.475 O3' 90.623 109.413 -63.913 66 C P 92.098 108.852 -64.191 O3' 95.325 108.909 -59.970 67 C P 96.737 108.403 -60.512 O3' 100.039 105.810 -57.528 68 G P 101.162 105.406 -58.591 O3' 98.796 104.178 -63.740 69 C P 98.191 102.767 -63.292 O3' 98.035 98.692 -66.407 70 C P 97.211 97.850 -65.323 O3' 97.584 92.810 -65.040 71 C P 96.216 92.592 -64.237 O3' 96.057 89.837 -59.994 72 G P 94.564 90.047 -59.456 O3' 93.682 92.389 -54.248 73 G P 92.084 92.256 -54.239 O3' 91.294 97.041 -52.040 74 G P 89.730 97.353 -51.941 O3' 88.769 102.279 -50.725 75 C P 87.193 102.038 -50.705 O3' 84.126 106.072 -51.874 76 G P 82.610 105.556 -51.797 O3' 78.915 107.164 -55.028 77 U P 77.711 106.434 -54.259 O3' 74.152 104.793 -57.867 78 A P 73.089 104.163 -56.851 O3' 70.661 100.420 -61.068 79 U P 69.459 100.935 -61.976 O3' 69.177 95.642 -62.981 80 G P 68.697 94.697 -61.785 O3' 69.311 90.576 -59.594 81 G P 67.955 90.209 -58.821 O3' 67.042 89.440 -53.252 82 C P 65.479 89.084 -53.157 O3' 63.546 89.772 -48.635 83 A P 61.933 89.784 -48.572 O3' 58.959 93.497 -46.366 84 A P 57.398 93.569 -46.706 O3' 54.910 97.537 -44.100 85 C P 53.386 97.085 -44.242 O3' 50.600 99.850 -48.586 86 G P 49.281 99.530 -49.434 O3' 47.435 101.674 -53.215 87 C P 46.101 100.993 -53.775 O3' 44.771 98.214 -58.540 88 C P 43.424 97.350 -58.554 O3' 42.541 95.249 -63.303 89 G P 41.287 94.251 -63.241 O3' 40.155 90.407 -66.095 90 A P 38.729 90.129 -65.419 O3' 36.892 85.379 -64.588 91 G P 35.565 85.370 -63.681 O3' 34.787 81.428 -60.221 92 C P 33.383 81.895 -59.629 O3' 32.580 80.854 -54.542 93 C P 31.133 81.439 -54.182 O3' 29.963 82.863 -49.461 94 A P 28.471 83.375 -49.205 O3' 26.253 84.037 -44.843 95 A P 24.838 84.524 -45.408 O3' 22.261 88.484 -42.910 96 G P 21.097 88.974 -43.907 O3' 19.732 93.562 -44.978 97 C P 18.517 93.152 -45.938 O3' 18.061 96.626 -50.476 98 U P 16.971 95.826 -51.329 O3' 16.209 96.290 -55.797 99 U P 14.909 95.354 -55.691 O3' 13.440 92.764 -59.996 100 C P 12.174 91.850 -59.652 O3' 11.752 86.460 -61.751 101 G P 10.637 85.500 -61.124 O3' 10.431 79.875 -59.909 102 C P 8.928 79.753 -59.374 O3' 8.021 75.916 -56.089 103 A P 6.548 76.245 -55.555 O3' 5.093 75.141 -50.721 104 G P 3.738 76.084 -50.492 O3' 1.886 77.300 -45.597 105 C P 0.470 77.899 -46.036 O3' -1.431 81.790 -43.043 106 C P -2.736 82.366 -43.777 O3' -3.800 87.482 -42.968 107 A P -5.262 86.907 -43.272 O3' -6.951 91.181 -46.844 108 U P -8.326 90.829 -47.592 O3' -9.212 92.172 -51.942 109 U P -10.731 91.657 -51.933 O3' -13.847 91.556 -56.406 110 G P -13.945 93.121 -56.739 O3' -10.489 95.155 -60.110 111 C P -11.379 95.308 -61.429 O3' -9.014 97.722 -64.852 112 A P -7.682 98.035 -65.712 O3' -3.107 96.656 -67.210 113 C P -2.468 97.769 -68.168 O3' 0.271 95.904 -73.039 114 U P 1.108 97.202 -73.461 O3' 4.051 94.084 -70.162 115 C P 3.235 93.596 -68.869 O3' 5.492 92.523 -64.498 116 C P 3.961 92.215 -64.148 O3' 3.931 92.955 -58.491 117 G P 2.669 93.462 -57.645 O3' 5.488 94.598 -52.861 118 G P 6.745 93.967 -52.102 O3' 7.750 93.186 -46.641 119 C P 9.290 93.259 -47.080 O3' 11.318 88.818 -44.086 120 U P 11.989 89.412 -42.757 O3' 13.435 83.865 -42.230 121 G P 14.922 83.913 -42.823 O3' 16.753 79.257 -44.848 122 C P 18.113 80.104 -44.884 O3' 20.698 77.282 -49.241 123 G P 21.741 77.771 -50.351 O3' 22.226 77.756 -54.904 124 A P 23.503 78.708 -54.743 O3' 24.482 81.371 -59.328 125 U P 25.609 82.496 -59.499 O3' 25.230 87.723 -61.747 126 G P 26.708 88.289 -61.540 O3' 27.154 93.385 -61.504 127 A P 28.644 93.696 -61.005 O3' 29.783 98.075 -58.763 128 A P 31.266 97.789 -58.233 O3' 33.059 99.488 -53.229 129 G P 34.624 99.197 -53.338 O3' 37.074 97.069 -49.118 130 G P 38.489 96.541 -49.666 O3' 39.922 91.774 -47.404 131 U P 41.457 91.709 -47.818 O3' 42.948 86.500 -48.977 132 G P 44.461 86.960 -48.678 O3' 47.803 85.786 -53.072 133 U P 49.290 86.300 -52.763 O3' 49.181 88.943 -47.666 134 A P 48.432 89.031 -46.250 O3' 54.187 89.025 -45.225 135 G P 55.702 88.599 -45.546 O3' 58.986 85.097 -44.136 136 A P 58.895 84.319 -45.524 O3' 54.341 81.515 -47.434 137 G P 53.116 82.532 -47.230 O3' 49.142 78.900 -45.037 138 A P 47.749 78.821 -44.256 O3' 45.193 75.969 -41.486 139 C P 43.814 76.771 -41.543 O3' 40.387 77.299 -37.242 140 U P 39.290 78.466 -37.310 O3' 37.495 80.973 -33.231 141 A P 36.526 81.684 -34.281 O3' 35.226 86.484 -31.296 142 G P 33.980 87.315 -31.841 O3' 35.380 92.753 -31.258 143 A P 34.838 94.118 -31.885 O3' 39.011 97.915 -33.546 144 C P 38.903 99.456 -33.156 O3' 37.635 99.508 -37.810 145 G P 37.564 100.263 -39.221 O3' 36.076 98.060 -43.828 146 G P 34.756 98.955 -43.954 O3' 30.624 97.273 -46.025 147 C P 29.648 98.476 -45.643 O3' 24.719 97.690 -44.502 148 A P 24.335 99.225 -44.309 O3' 20.452 100.420 -40.972 149 C P 20.411 102.002 -40.738 O3' 18.990 104.287 -36.104 150 C P 19.290 105.858 -36.226 O3' 20.352 108.539 -32.002 151 C P 20.503 110.007 -32.613 O3' 23.627 113.169 -29.862 152 A P 23.450 114.582 -30.587 O3' 26.910 118.281 -30.658 153 C P 26.022 119.356 -31.454 O3' 28.730 122.112 -35.009 154 C P 27.604 122.955 -35.756 O3' 28.703 124.728 -40.552 155 U P 27.356 125.549 -40.814 O3' 25.529 125.332 -45.743 156 A P 24.359 126.433 -45.644 O3' 20.261 124.075 -49.081 157 A P 19.693 125.129 -50.136 O3' 17.641 122.853 -54.380 158 G P 16.197 123.474 -54.036 O3' 12.328 119.704 -54.003 159 G P 11.052 120.641 -53.750 O3' 7.569 119.292 -50.090 160 C P 6.690 120.629 -50.192 O3' 4.949 122.354 -45.514 161 A P 4.107 123.643 -45.935 O3' 3.979 128.034 -43.756 162 A P 2.912 128.597 -44.812 O3' 6.229 132.118 -47.254 163 A P 7.512 131.193 -47.038 O3' 11.474 133.817 -44.074 164 C P 12.708 132.989 -43.468 O3' 16.427 134.545 -40.567 165 G P 17.433 133.368 -40.978 O3' 16.469 128.379 -38.020 166 C P 17.205 126.960 -37.923 O3' 15.101 122.573 -37.268 167 U P 16.628 122.137 -37.127 O3' 16.637 117.007 -39.159 168 A P 18.016 116.283 -39.495 O3' 19.153 111.680 -43.280 169 U P 18.938 110.181 -42.801 O3' 21.315 109.833 -47.723 170 G P 22.746 110.173 -47.088 O3' 26.488 112.082 -49.207 171 G P 27.648 111.312 -48.421 O3' 32.303 113.726 -45.988 172 U P 33.087 112.401 -45.561 O3' 36.328 113.216 -41.651 173 G P 36.631 111.653 -41.484 O3' 37.814 109.889 -37.069 174 A P 38.076 108.393 -37.580 O3' 40.882 107.072 -41.686 175 A P 40.672 105.495 -41.751 O3' 44.742 102.613 -43.719 176 G P 44.497 101.067 -43.402 O3' 48.813 98.164 -40.818 177 G P 49.526 97.216 -41.877 O3' 45.545 93.942 -43.073 178 C P 45.161 94.162 -44.605 O3' 50.832 92.715 -44.333 179 A P 51.197 92.768 -42.792 O3' 49.965 90.467 -38.469 180 U P 50.366 91.801 -37.704 O3' 48.953 93.218 -33.889 181 A P 49.732 92.042 -33.130 O3' 47.860 91.290 -28.300 182 G P 48.982 90.293 -27.762 O3' 48.738 84.654 -27.103 183 U P 50.193 83.987 -27.077 O3' 50.553 78.801 -27.465 184 C P 52.107 78.617 -27.801 O3' 53.607 75.274 -31.458 185 C P 55.195 75.376 -31.361 O3' 57.233 73.994 -36.293 186 A P 58.813 74.116 -36.500 O3' 62.002 76.121 -40.780 187 G P 63.538 76.424 -40.456 O3' 66.407 80.421 -40.923 188 G P 67.670 79.902 -40.089 O3' 70.815 83.433 -37.925 189 G P 71.873 82.457 -37.225 O3' 73.549 83.353 -32.319 190 A P 74.713 82.366 -31.836 O3' 75.520 78.668 -36.155 191 G P 75.872 78.466 -37.706 O3' 78.627 74.479 -39.416 192 U P 79.437 75.120 -40.641 O3' 80.231 72.321 -44.941 193 G P 80.789 73.445 -45.934 O3' 79.483 72.524 -51.046 194 G P 79.913 73.810 -51.896 O3' 77.330 74.752 -56.475 195 C P 78.234 75.952 -57.031 O3' 75.726 79.309 -60.106 196 G P 77.143 80.158 -60.284 O3' 77.432 84.947 -60.128 197 a P 78.984 85.029 -60.546 O3' 81.008 85.946 -55.476 142 syn 176 syn 7 84 S S t 9 175 S S c 10 34 + + c 11 33 + + c 11 36 S W c 12 32 - - c 13 31 - - c 14 30 + + c 15 29 + + c 16 28 + + c 19 26 + + c 20 25 + + c 21 24 S H t 22 168 W W t 24 170 S S t 38 150 + + c 39 149 + + c 40 148 - - c 41 147 + + c 42 146 W W c 43 145 + + c 44 143 W H t 46 130 S S t 48 90 - - c 49 89 + + c 50 88 + + c 51 87 + + c 52 86 + + c 53 85 + + c 54 84 S H t 55 83 H S t 56 82 W W c 57 81 + + c 58 80 + + c 59 78 W H t 60 61 S H c 62 77 W W c 63 76 + + c 64 75 + + c 65 74 + + c 66 73 + + c 67 72 + + c 88 133 H H t 89 132 H S t 91 131 W W c 92 130 + + c 93 129 + + c 96 127 W W c 97 126 + + c 98 125 W W c 99 124 - - c 100 123 + + c 101 122 + + c 102 121 + + c 103 120 - - c 104 119 + + c 105 118 + + c 106 117 + + c 135 136 S H c 135 185 + + c 136 185 W S t 137 184 + + c 138 183 - - c 139 182 + + c 140 181 - - c 141 180 - - c 142 177 H W t 151 173 + + c 152 172 - - c 153 171 + + c 154 170 + + c 155 168 W H t 156 157 S H c 157 169 - - c 158 167 W W c 158 169 W W c 159 166 + + c 160 165 + + c 33 35 ! ! ! 94 129 ! ! ! 95 128 ! ! ! 11 37 ! ! ! 12 35 ! ! ! 49 132 ! ! ! 95 146 ! ! ! 6 56 ! ! ! 10 174 ! ! ! 23 155 ! ! ! 24 154 ! ! ! 25 171 ! ! ! 37 38 ! ! ! 37 173 ! ! ! 43 94 ! ! ! 44 45 ! ! ! 45 93 ! ! ! 46 92 ! ! ! 47 48 ! ! ! 47 131 ! ! ! 84 85 ! ! ! 93 94 ! ! ! 113 114 ! ! ! 134 138 ! ! ! 10 34 7 19 26 3 62 77 6 48 90 11 91 131 3 95 128 12 158 167 3 151 173 4 38 150 6 137 184 5 SG1 17 18 SG2 22 23 SG3 27 27 SG4 35 37 SG5 44 47 SG6 59 61 SG7 68 71 SG8 78 79 SG9 94 94 SG10 107 116 SG11 132 136 SG12 142 144 SG13 155 157 SG14 161 164 SG15 168 169 SG16 174 179 SG17 185 185 SG18 197 197 1 165.883 144.346 2 175.670 152.167 3 185.457 159.987 4 195.244 167.808 5 205.031 175.628 6 214.818 183.449 7 234.393 199.090 8 244.180 206.911 9 253.967 214.731 10 273.541 230.372 11 283.329 238.193 12 293.116 246.013 13 302.903 253.834 14 312.690 261.654 15 322.477 269.475 16 332.264 277.296 17 338.137 281.988 18 344.009 286.680 19 317.367 310.873 20 322.339 322.372 21 327.311 333.871 22 328.749 352.073 23 311.990 359.319 24 299.713 345.804 25 294.741 334.305 26 289.769 322.806 27 319.367 305.477 28 313.495 300.785 29 303.708 292.964 30 293.921 285.144 31 284.134 277.323 32 274.346 269.503 33 264.559 261.682 34 254.772 253.861 35 250.080 259.734 36 245.387 265.606 37 240.695 271.478 38 220.228 326.135 39 209.294 320.019 40 198.361 313.902 41 187.428 307.786 42 176.494 301.670 43 165.561 295.553 44 202.576 288.099 45 195.059 288.099 46 187.542 288.099 47 180.025 288.099 48 172.509 288.099 49 172.509 275.571 50 172.509 263.043 51 172.509 250.515 52 172.509 237.988 53 172.509 225.460 54 172.509 212.932 55 172.509 200.404 56 172.509 187.876 57 172.509 175.348 58 172.509 162.820 59 172.509 150.292 60 172.509 137.764 61 172.509 112.708 62 172.509 87.652 63 172.509 75.124 64 172.509 62.596 65 172.509 50.068 66 172.509 37.540 67 172.509 25.012 68 174.203 10.743 69 164.660 0.000 70 150.290 0.000 71 140.747 10.743 72 142.441 25.012 73 142.441 37.540 74 142.441 50.068 75 142.441 62.596 76 142.441 75.124 77 142.441 87.652 78 142.441 100.180 79 142.441 125.236 80 142.441 162.820 81 142.441 175.348 82 142.441 187.876 83 142.441 200.404 84 142.441 212.932 85 142.441 225.460 86 142.441 237.988 87 142.441 250.515 88 142.441 263.043 89 142.441 275.571 90 142.441 288.099 91 142.441 313.155 92 142.441 325.683 93 142.441 338.211 94 142.441 350.739 95 142.441 363.267 96 142.441 375.795 97 142.441 388.323 98 142.441 400.851 99 142.441 413.379 100 142.441 425.907 101 142.441 438.435 102 142.441 450.963 103 142.441 463.491 104 142.441 476.019 105 142.441 488.547 106 142.441 501.075 107 133.935 510.194 108 130.413 522.156 109 132.620 534.430 110 140.089 544.416 111 151.240 550.000 112 163.710 550.000 113 174.861 544.416 114 182.330 534.430 115 184.537 522.156 116 181.015 510.194 117 172.509 501.075 118 172.509 488.547 119 172.509 476.019 120 172.509 463.491 121 172.509 450.963 122 172.509 438.435 123 172.509 425.907 124 172.509 413.379 125 172.509 400.851 126 172.509 388.323 127 172.509 375.795 128 172.509 363.267 129 172.509 338.211 130 172.509 325.683 131 172.509 313.155 132 180.025 313.155 133 187.542 313.155 134 195.059 313.155 135 202.576 313.155 136 210.092 313.155 137 85.281 285.095 138 96.214 291.212 139 107.148 297.328 140 118.081 303.444 141 129.015 309.561 142 139.872 341.474 143 143.542 334.914 144 147.212 328.354 145 150.881 321.794 146 161.815 327.910 147 172.748 334.026 148 183.682 340.143 149 194.615 346.259 150 205.549 352.375 151 227.415 364.608 152 238.349 370.724 153 249.282 376.841 154 260.216 382.957 155 271.149 389.073 156 282.083 395.190 157 303.950 407.422 158 325.816 419.655 159 336.750 425.771 160 347.683 431.888 161 359.309 440.333 162 373.344 437.249 163 380.359 424.709 164 375.643 411.135 165 362.363 405.647 166 351.429 399.531 167 340.496 393.415 168 329.562 387.298 169 307.695 375.066 170 274.895 356.717 171 263.962 350.600 172 253.028 344.484 173 242.095 338.368 174 245.765 331.808 175 249.434 325.248 176 253.104 318.687 177 256.774 312.127 178 260.444 305.567 179 264.114 299.007 180 143.694 283.321 181 132.760 277.204 182 121.827 271.088 183 110.893 264.972 184 99.960 258.855 185 103.630 252.295 186 78.093 246.623 187 67.160 240.506 188 56.226 234.390 189 45.293 228.274 190 34.359 222.157 191 52.935 158.314 192 59.472 147.626 193 66.009 136.939 194 72.546 126.252 195 79.083 115.564 196 85.620 104.877 197 89.542 98.465 1 22 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 1 2 3 4 5 6 AAG CCACACAAAC CAGACGGCC Crystallography ? ? Angstroms 1 A O3' 78.814 89.208 -49.345 2 A P 77.858 88.374 -48.366 O3' 73.515 90.769 -47.266 3 G P 72.498 89.763 -46.536 O3' 67.866 87.371 -49.174 4 C P 67.083 86.208 -48.404 O3' 65.048 82.427 -51.394 5 C P 64.539 81.345 -50.342 O3' 64.283 76.384 -51.685 6 A P 64.001 75.384 -50.470 O3' 65.714 70.124 -49.067 7 C P 64.436 70.028 -48.107 O3' 66.877 66.660 -44.146 8 A P 66.554 66.772 -42.583 O3' 68.996 66.822 -38.438 9 C P 67.689 66.908 -37.518 O3' 68.682 69.435 -32.725 10 A P 67.441 69.522 -31.705 O3' 67.436 73.038 -28.612 11 A P 66.249 74.110 -28.840 O3' 64.861 77.527 -24.783 12 A P 63.708 78.488 -25.324 O3' 63.321 83.314 -22.581 13 C P 61.996 83.876 -23.275 O3' 63.435 88.485 -25.991 14 C P 62.159 88.964 -26.816 O3' 63.110 91.822 -31.189 15 A P 61.593 92.313 -31.311 O3' 59.747 91.317 -36.129 16 G P 58.207 91.746 -36.243 O3' 56.238 93.087 -39.982 17 A P 55.624 94.547 -39.739 O3' 60.998 95.152 -41.631 18 C P 62.387 94.853 -40.895 O3' 66.895 96.978 -42.665 19 G P 67.837 96.229 -41.612 O3' 72.061 98.898 -39.856 20 G P 72.550 97.913 -38.690 O3' 74.568 100.452 -34.569 21 C P 74.980 99.339 -33.489 O3' 75.504 100.629 -28.685 22 C P 75.373 99.422 -27.649 O3' 73.005 99.883 -22.391 15 syn 16 syn 16 17 ! ! ! SG1 1 1 SG2 8 10 SG3 16 16 1 115.191 114.153 2 111.269 120.566 3 104.732 131.253 4 98.195 141.940 5 91.658 152.628 6 85.121 163.315 7 78.584 174.002 8 0.000 237.388 9 6.560 241.058 10 13.120 244.728 11 19.680 248.397 12 30.614 254.514 13 41.547 260.630 14 52.480 266.746 15 63.414 272.863 16 191.357 212.810 17 196.049 206.938 18 186.262 199.118 19 176.475 191.297 20 166.688 183.477 21 156.900 175.656 22 147.113 167.835 1 3 3 2 1 C Au 3 5MU Crystallography ? ? Angstroms 1 C O3' 51.000 106.153 -32.986 2 A P 51.956 104.859 -33.064 O3' 50.473 100.957 -36.562 3 u O3' 53.318 96.878 -40.427 P 51.472 99.728 -36.380 1 235.198 238.220 2 225.411 230.400 3 215.623 222.579 1 22 + + c 2 21 + + c 3 20 + + c 4 19 + + c 5 18 + + c 6 17 - - c 80 2 S S t 137 16 H W c 186 15 W H c 187 14 + + c 188 13 + + c 189 12 S H t 190 11 H H t 191 7 + + c 192 6 - - c 193 5 + + c 194 4 + + c 195 3 + + c 196 2 S H t 184 16 ! ! ! 58 2 ! ! ! 1 15 ! ! ! 59 1 ! ! ! 81 3 ! ! ! 1 22 6 186 15 5 191 7 6 7 3 W W c 8 2 - - c 9 1 + + c 175 1 ! ! ! 84 3 ! ! ! 7 3 3