1 197 1 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 1001 1002 1003 1004 1005 1006 1007 1008 1009 1010 1011 1012 1013 1014 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 gGCCGUGUGC CUUGCGCCGG GAAACCACGC AAGGGAUGGU GUCAAAUUCG GCGAAACCUA AGCGCCCGCC CGGGCGUAUG GCAACGCCGA GCCAAGCUUC GCAGCCAUUG CACUCCGGCU GCGAUGAAGG UGUAGAGACU AGACGGCACC CACCUAAGGC AAACGCUAUG GUGAAGGCAU AGUCCAGGGA GUGGCGa 1 GTP 197 A23 LOOP1 22 23 LOOP2 104 119 LOOP3 68 71 LOOP4 161 164 Crystallography ? ? Angstroms 1 g O3' 58.906 97.747 -24.512 2 G P 60.079 98.779 -24.058 O3' 61.402 104.032 -25.817 3 C P 61.776 104.973 -27.055 O3' 64.789 108.261 -27.756 4 C P 64.418 109.063 -29.099 O3' 67.629 110.600 -33.406 5 G P 66.718 111.235 -34.544 O3' 67.548 110.270 -40.053 6 U P 66.296 110.647 -40.957 O3' 65.819 108.694 -45.391 7 G P 64.482 109.538 -45.664 O3' 61.425 107.047 -49.216 8 U P 60.123 107.982 -49.263 O3' 55.481 106.067 -50.270 9 G P 54.506 107.253 -49.795 O3' 49.645 105.710 -48.311 10 C P 48.849 107.117 -48.244 O3' 45.709 108.420 -44.498 11 C P 45.108 109.687 -45.304 O3' 43.178 113.593 -41.906 12 U P 43.066 115.129 -42.360 O3' 43.748 119.254 -39.677 13 U P 43.348 120.340 -40.810 O3' 45.758 124.736 -41.513 14 G P 45.377 125.371 -42.946 O3' 48.228 128.321 -45.993 15 C P 47.491 128.582 -47.408 O3' 48.960 128.712 -52.083 16 G P 47.724 128.565 -53.094 O3' 48.751 126.994 -58.070 17 C P 47.418 127.304 -58.902 O3' 44.953 124.129 -61.730 18 C P 43.829 124.996 -62.487 O3' 40.253 122.513 -64.511 19 G P 39.477 122.737 -63.142 O3' 36.273 117.970 -63.436 20 G P 34.722 118.362 -63.135 O3' 31.167 115.400 -60.896 21 G P 30.028 116.555 -60.853 O3' 26.655 117.253 -57.462 22 A P 25.973 118.543 -58.115 O3' 28.204 123.179 -56.086 23 A P 29.328 123.531 -55.003 O3' 30.522 124.299 -50.086 24 A P 31.983 123.747 -49.749 O3' 33.188 121.022 -45.169 25 C P 34.700 120.511 -45.333 O3' 36.019 115.409 -46.538 26 C P 37.589 115.329 -46.887 O3' 38.749 111.521 -50.536 27 A P 40.337 111.663 -50.408 O3' 42.366 110.741 -55.008 28 C P 43.903 110.522 -54.590 O3' 47.760 112.493 -57.181 29 G P 49.037 112.581 -56.214 O3' 53.247 114.820 -56.489 30 C P 53.724 114.114 -55.136 O3' 56.806 117.523 -52.610 31 A P 57.403 116.668 -51.388 O3' 59.186 119.425 -47.244 32 A P 59.569 118.120 -46.438 O3' 59.631 119.405 -41.237 33 G P 59.688 118.201 -40.168 O3' 57.461 117.405 -35.247 34 G P 57.408 116.060 -34.350 O3' 53.456 112.979 -31.513 35 G P 51.883 112.792 -31.083 O3' 48.472 113.304 -29.263 36 A P 47.886 111.930 -29.842 O3' 42.678 111.690 -30.130 37 U P 42.766 110.102 -30.193 O3' 38.973 107.688 -33.979 38 G P 38.393 106.200 -33.820 O3' 35.515 105.292 -29.676 39 G P 35.285 103.704 -29.632 O3' 31.594 101.021 -27.493 40 U P 31.634 99.426 -27.705 O3' 27.902 95.961 -27.557 41 G P 28.413 94.506 -27.995 O3' 25.648 91.208 -30.822 42 U P 26.395 89.934 -31.440 O3' 25.786 87.576 -35.561 43 C P 26.914 86.454 -35.667 O3' 28.559 84.425 -39.984 44 A P 29.207 83.143 -39.286 O3' 34.613 81.712 -40.959 45 A P 34.853 80.181 -41.309 O3' 34.202 79.042 -46.261 46 A P 35.569 78.229 -46.364 O3' 37.355 79.011 -51.162 47 U P 38.830 78.407 -51.279 O3' 43.836 81.233 -50.370 48 U P 44.885 80.161 -50.934 O3' 46.107 77.688 -55.116 49 C P 47.515 78.249 -55.657 O3' 48.816 78.080 -60.507 50 G P 50.313 78.650 -60.585 O3' 52.307 82.964 -63.709 51 G P 53.667 83.564 -63.142 O3' 55.394 88.200 -64.826 52 C P 56.451 88.979 -63.895 O3' 57.148 93.944 -64.893 53 G P 58.269 94.493 -63.877 O3' 58.613 98.216 -61.692 54 A P 60.128 98.025 -61.331 O3' 61.783 100.727 -57.305 55 A P 63.045 100.750 -56.325 O3' 65.012 104.522 -52.594 56 A P 66.525 104.077 -52.868 O3' 68.330 104.508 -47.600 57 C P 69.849 104.001 -47.595 O3' 71.918 99.748 -45.412 58 C P 73.395 99.649 -46.036 O3' 75.819 95.652 -47.119 59 U P 77.228 96.098 -47.758 O3' 79.912 93.496 -50.968 60 A P 81.074 94.493 -51.476 O3' 81.739 93.362 -57.429 61 A P 83.040 92.583 -57.945 O3' 83.132 90.984 -63.547 62 G P 84.437 91.772 -64.050 O3' 83.430 94.572 -68.111 63 C P 84.698 95.526 -68.364 O3' 84.346 100.339 -69.500 64 G P 85.881 100.794 -69.391 O3' 86.970 105.637 -68.014 65 C P 88.566 105.602 -67.845 O3' 91.018 108.493 -64.400 66 C P 92.508 107.954 -64.667 O3' 95.765 107.876 -60.467 67 C P 97.153 107.227 -60.903 O3' 100.491 104.918 -57.793 68 G P 101.655 104.609 -58.869 O3' 99.173 103.202 -64.084 69 C P 98.835 101.646 -63.967 O3' 99.060 97.672 -66.896 70 C P 97.788 97.632 -65.902 O3' 96.001 92.778 -65.565 71 C P 95.536 92.012 -64.234 O3' 96.488 89.091 -60.943 72 G P 95.092 89.305 -60.175 O3' 94.650 91.580 -55.038 73 G P 93.058 91.441 -54.903 O3' 91.926 96.389 -52.453 74 G P 90.332 96.462 -52.315 O3' 89.082 101.433 -51.182 75 C P 87.487 101.300 -51.250 O3' 84.786 105.298 -52.637 76 G P 83.289 104.711 -52.521 O3' 79.301 106.116 -55.472 77 U P 78.212 105.186 -54.733 O3' 74.708 103.619 -58.474 78 A P 73.599 102.901 -57.517 O3' 70.630 99.195 -61.344 79 U P 69.946 99.881 -62.636 O3' 70.263 94.229 -63.126 80 G P 69.222 93.352 -62.234 O3' 69.748 89.248 -59.572 81 G P 68.277 89.329 -58.982 O3' 67.616 88.225 -53.827 82 C P 66.022 88.053 -53.739 O3' 64.048 89.071 -48.754 83 A P 62.512 88.698 -49.035 O3' 59.211 92.076 -47.179 84 A P 57.697 92.492 -47.545 O3' 55.614 96.289 -44.627 85 C P 54.088 95.915 -44.807 O3' 51.296 98.647 -49.122 86 G P 50.030 98.311 -50.058 O3' 48.357 100.841 -53.909 87 C P 46.958 100.093 -54.091 O3' 44.719 97.183 -58.401 88 C P 43.707 96.077 -58.939 O3' 42.721 94.454 -63.581 89 G P 41.404 93.560 -63.436 O3' 40.420 89.671 -66.506 90 A P 39.054 89.261 -65.783 O3' 37.577 84.450 -65.187 91 G P 36.346 84.435 -64.157 O3' 35.523 80.498 -60.806 92 C P 34.088 80.942 -60.245 O3' 32.676 79.907 -55.131 93 C P 31.378 80.611 -54.459 O3' 30.542 81.874 -49.688 94 A P 28.985 82.280 -49.634 O3' 26.775 83.257 -44.957 95 A P 25.366 83.476 -45.712 O3' 22.835 87.514 -43.314 96 G P 21.783 88.142 -44.353 O3' 20.448 92.249 -45.235 97 C P 19.348 92.186 -46.392 O3' 18.470 95.424 -51.001 98 U P 17.696 94.612 -52.148 O3' 16.903 95.064 -56.173 99 U P 15.556 94.178 -56.061 O3' 14.164 91.640 -60.331 100 C P 13.004 90.539 -60.215 O3' 12.566 85.085 -62.212 101 G P 11.097 84.877 -61.592 O3' 10.289 79.413 -59.852 102 C P 10.513 77.821 -59.800 O3' 7.044 76.316 -55.671 103 A P 6.930 74.719 -55.517 O3' 5.386 74.848 -49.892 104 G P 3.849 75.200 -50.199 O3' 3.169 75.434 -46.741 105 C P 1.572 75.628 -46.808 O3' -0.892 80.234 -44.028 106 C P -1.958 81.442 -44.046 O3' -2.666 85.777 -42.894 107 A P -4.153 85.736 -43.496 O3' -5.638 90.336 -46.821 108 U P -7.147 90.332 -47.400 O3' -8.056 90.738 -52.156 109 U P -9.621 90.391 -52.312 O3' -12.563 90.340 -57.095 110 G P -13.007 91.813 -57.549 O3' -9.537 94.092 -60.145 111 C P -10.221 94.236 -61.567 O3' -7.966 94.916 -65.693 112 A P -7.530 96.446 -65.888 O3' -2.511 94.586 -67.926 113 C P -1.741 95.910 -68.414 O3' 1.141 94.916 -73.358 114 U P 1.571 96.404 -73.796 O3' 4.356 93.949 -70.718 115 C P 3.661 93.509 -69.333 O3' 6.224 91.436 -64.577 116 C P 4.780 91.153 -63.940 O3' 5.161 92.008 -58.907 117 G P 3.707 92.403 -58.353 O3' 6.474 93.347 -53.330 118 G P 7.719 92.651 -52.593 O3' 8.060 92.799 -47.648 119 C P 9.583 92.308 -47.619 O3' 12.173 88.862 -44.368 120 U P 13.189 87.776 -43.751 O3' 14.584 83.525 -42.696 121 G P 15.968 83.583 -43.525 O3' 17.899 78.802 -45.128 122 C P 19.216 78.942 -46.029 O3' 21.079 76.408 -49.860 123 G P 22.331 77.258 -50.405 O3' 23.544 77.458 -55.344 124 A P 24.633 78.631 -55.500 O3' 25.087 80.608 -60.241 125 U P 26.185 81.716 -60.597 O3' 25.420 87.310 -61.741 126 G P 27.003 87.510 -61.924 O3' 27.665 92.582 -62.128 127 A P 29.225 92.819 -61.875 O3' 30.294 97.297 -59.514 128 A P 31.772 97.347 -58.902 O3' 33.855 98.558 -53.801 129 G P 35.418 98.279 -53.856 O3' 37.738 96.058 -49.650 130 G P 39.152 95.520 -50.211 O3' 40.627 91.093 -47.831 131 U P 42.162 90.823 -48.231 O3' 43.420 85.607 -49.271 132 G P 45.011 85.819 -49.288 O3' 48.623 84.778 -53.241 133 U P 50.036 85.498 -53.590 O3' 49.564 88.442 -48.073 134 A P 48.704 88.640 -46.740 O3' 54.403 89.161 -44.288 135 G P 55.948 89.322 -44.597 O3' 59.572 85.022 -44.323 136 A P 59.587 84.251 -45.723 O3' 55.131 81.191 -47.662 137 G P 53.764 81.997 -47.416 O3' 49.957 77.863 -46.063 138 A P 48.597 78.045 -45.223 O3' 46.051 75.002 -42.330 139 C P 44.657 75.776 -42.428 O3' 41.328 76.347 -38.421 140 U P 40.253 77.519 -38.230 O3' 38.240 79.856 -34.349 141 A P 37.278 80.780 -35.228 O3' 36.078 85.220 -32.045 142 G P 34.774 85.960 -32.599 O3' 36.159 91.265 -32.063 143 A P 35.709 92.711 -32.596 O3' 39.997 96.658 -33.650 144 C P 39.800 98.244 -33.745 O3' 38.155 98.801 -38.276 145 G P 38.214 99.108 -39.853 O3' 36.826 97.101 -44.172 146 G P 35.468 97.954 -44.299 O3' 31.458 96.168 -46.682 147 C P 30.380 97.312 -46.424 O3' 25.549 96.824 -45.089 148 A P 24.828 98.185 -44.635 O3' 21.242 99.487 -41.550 149 C P 21.346 101.076 -41.374 O3' 19.695 103.312 -36.871 150 C P 20.086 104.856 -36.626 O3' 20.957 107.406 -32.791 151 C P 21.283 108.856 -33.370 O3' 24.076 111.909 -30.505 152 A P 24.102 113.340 -31.216 O3' 27.860 116.881 -31.117 153 C P 26.943 118.022 -31.774 O3' 29.528 120.925 -35.459 154 C P 28.532 121.794 -36.369 O3' 29.317 123.154 -41.151 155 U P 28.159 124.264 -41.152 O3' 26.436 124.637 -46.370 156 A P 25.123 125.533 -46.552 O3' 21.365 123.028 -49.690 157 A P 20.340 123.978 -50.441 O3' 18.293 122.057 -54.933 158 G P 16.746 122.326 -54.627 O3' 13.317 118.528 -54.554 159 G P 12.033 119.469 -54.267 O3' 8.282 118.426 -50.957 160 C P 7.626 119.893 -50.750 O3' 5.704 121.053 -46.211 161 A P 4.873 122.400 -46.444 O3' 4.867 126.658 -43.975 162 A P 3.920 127.616 -44.858 O3' 7.122 131.137 -47.588 163 A P 8.415 130.191 -47.427 O3' 12.509 132.497 -44.806 164 C P 13.690 131.753 -44.009 O3' 17.200 133.463 -41.440 165 G P 18.168 132.193 -41.441 O3' 17.618 127.282 -38.420 166 C P 17.962 125.702 -38.337 O3' 15.939 121.406 -38.010 167 U P 17.443 121.042 -37.628 O3' 17.382 115.714 -40.062 168 A P 18.804 114.971 -40.055 O3' 19.687 110.400 -42.166 169 U P 20.184 109.010 -42.816 O3' 22.174 107.894 -46.851 170 G P 23.571 108.673 -47.076 O3' 27.275 110.930 -49.593 171 G P 28.512 110.109 -48.969 O3' 32.853 112.586 -46.724 172 U P 33.726 111.403 -46.029 O3' 37.157 112.180 -42.241 173 G P 37.559 110.630 -42.110 O3' 38.615 108.629 -37.966 174 A P 38.819 107.118 -38.511 O3' 41.659 106.064 -42.214 175 A P 41.320 104.505 -42.311 O3' 45.568 101.822 -44.216 176 G P 45.177 100.269 -44.068 O3' 49.180 97.266 -41.352 177 G P 50.023 96.484 -42.418 O3' 46.748 92.699 -44.297 178 C P 45.969 92.810 -45.698 O3' 51.299 91.717 -45.189 179 A P 52.211 92.124 -43.906 O3' 50.421 89.276 -39.422 180 U P 50.947 90.488 -38.573 O3' 49.928 92.016 -34.894 181 A P 50.450 90.673 -34.196 O3' 48.938 90.274 -29.232 182 G P 49.889 89.131 -28.638 O3' 49.417 83.721 -27.949 183 U P 50.860 83.007 -27.859 O3' 50.820 77.925 -28.148 184 C P 52.243 77.261 -28.472 O3' 54.271 74.240 -32.832 185 C P 55.723 74.348 -32.161 O3' 57.905 73.053 -37.353 186 A P 59.391 73.148 -37.953 O3' 62.526 75.765 -40.755 187 G P 64.092 76.079 -40.955 O3' 67.387 79.485 -41.543 188 G P 68.589 78.866 -40.684 O3' 71.644 82.528 -38.467 189 G P 72.705 81.478 -37.899 O3' 74.295 82.620 -32.821 190 A P 75.406 81.651 -32.215 O3' 76.501 77.925 -36.488 191 G P 76.634 77.634 -38.076 O3' 79.437 73.915 -39.966 192 U P 79.969 74.409 -41.410 O3' 80.462 71.236 -45.024 193 G P 81.254 72.435 -45.749 O3' 79.864 71.407 -51.263 194 G P 80.264 72.529 -52.356 O3' 77.978 73.867 -56.790 195 C P 78.591 75.287 -57.238 O3' 76.344 78.506 -60.388 196 G P 77.574 79.491 -60.672 O3' 78.146 84.405 -60.158 197 a P 79.401 84.022 -61.106 O3' 81.579 85.424 -56.203 104 syn 114 syn 119 syn 134 syn 142 syn 169 syn 176 syn 7 84 S S t 10 34 + + c 11 33 + + c 11 36 S W c 12 32 - - c 13 31 - - c 14 30 + + c 15 29 + + c 16 28 W W c 17 19 W H c 17 27 W W c 19 26 + + c 20 25 + + c 21 24 S H t 38 150 + + c 39 149 + + c 40 148 - - c 41 147 + + c 42 146 W W c 43 145 + + c 44 143 W H t 48 90 - - c 49 89 + + c 50 88 + + c 51 87 + + c 52 86 + + c 53 85 W W c 54 84 S H t 54 85 W W c 55 83 H S t 56 82 W W c 57 81 + + c 58 80 + + c 60 61 S H c 62 77 W W c 63 76 + + c 64 75 + + c 65 74 + + c 66 73 + + c 67 72 + + c 69 70 S H c 91 131 W W c 92 130 + + c 93 129 + + c 96 127 W W c 97 126 + + c 98 125 W W c 99 124 - - c 100 123 + + c 101 122 + + c 102 121 W W c 103 104 S S c 103 120 W W c 104 119 + + c 105 118 + + c 106 117 + + c 135 136 S H c 135 185 + + c 136 185 H S t 137 184 + + c 138 183 - - c 139 182 + + c 140 181 - - c 141 180 - - c 151 173 + + c 152 172 - - c 153 171 + + c 154 170 + + c 155 170 W W c 156 157 S H c 158 167 W W c 159 166 + + c 160 165 + + c 33 35 ! ! ! 62 76 ! ! ! 88 133 ! ! ! 89 132 ! ! ! 135 184 ! ! ! 10 175 ! ! ! 11 37 ! ! ! 12 35 ! ! ! 46 130 ! ! ! 49 132 ! ! ! 94 146 ! ! ! 6 56 ! ! ! 10 174 ! ! ! 23 155 ! ! ! 24 154 ! ! ! 25 171 ! ! ! 37 38 ! ! ! 43 94 ! ! ! 45 93 ! ! ! 46 92 ! ! ! 47 48 ! ! ! 47 131 ! ! ! 55 79 ! ! ! 84 85 ! ! ! 85 177 ! ! ! 110 111 ! ! ! 134 138 ! ! ! 144 145 ! ! ! 179 180 ! ! ! 10 34 8 19 26 3 55 83 4 48 90 5 91 131 3 96 127 8 62 77 6 158 167 3 151 173 4 38 150 6 137 184 5 SG1 18 18 SG2 22 23 SG3 35 37 SG4 44 47 SG5 53 54 SG6 59 61 SG7 68 71 SG8 78 79 SG9 84 85 SG10 94 95 SG11 104 119 SG12 128 128 SG13 132 136 SG14 142 144 SG15 155 157 SG16 161 164 SG17 168 169 SG18 174 179 SG19 185 185 SG20 197 197 1 129.316 347.602 2 132.268 334.880 3 135.221 322.158 4 138.173 309.436 5 141.125 296.714 6 144.077 283.992 7 149.982 258.549 8 152.934 245.827 9 155.886 233.105 10 161.791 207.661 11 164.743 194.939 12 167.695 182.217 13 170.647 169.495 14 173.600 156.773 15 176.552 144.051 16 179.504 131.329 17 182.456 118.607 18 185.409 105.886 19 188.361 93.164 20 191.313 80.442 21 194.265 67.720 22 204.333 51.566 23 222.874 55.869 24 224.798 74.805 25 221.846 87.527 26 218.894 100.249 27 212.989 125.693 28 210.037 138.415 29 207.085 151.137 30 204.132 163.859 31 201.180 176.581 32 198.228 189.302 33 195.276 202.024 34 192.323 214.746 35 199.957 216.518 36 207.590 218.289 37 215.223 220.060 38 274.622 195.854 39 274.622 208.914 40 274.622 221.974 41 274.622 235.034 42 274.622 248.094 43 274.622 261.154 44 271.725 227.277 45 273.750 234.847 46 275.775 242.417 47 277.800 249.986 48 279.825 257.556 49 267.209 260.931 50 254.592 264.306 51 241.976 267.681 52 229.360 271.056 53 216.743 274.431 54 191.510 281.181 55 166.278 287.930 56 153.661 291.305 57 141.045 294.680 58 128.429 298.055 59 120.859 300.080 60 113.289 302.105 61 105.719 304.130 62 93.581 373.616 63 81.399 378.323 64 69.217 383.030 65 57.034 387.738 66 44.852 392.445 67 32.670 397.152 68 19.431 404.161 69 5.399 398.918 70 0.000 384.945 71 6.861 371.629 72 21.373 367.915 73 33.555 363.208 74 45.737 358.501 75 57.919 353.793 76 70.101 349.086 77 82.284 344.379 78 121.389 332.384 79 128.958 330.359 80 136.528 328.335 81 149.145 324.960 82 161.761 321.585 83 174.377 318.210 84 186.994 314.835 85 212.227 308.085 86 237.459 301.335 87 250.076 297.960 88 262.692 294.585 89 275.308 291.210 90 287.925 287.836 91 313.158 281.086 92 325.774 277.711 93 338.390 274.336 94 351.007 270.961 95 376.239 264.211 96 388.856 260.836 97 401.472 257.461 98 414.089 254.086 99 426.705 250.712 100 439.321 247.337 101 451.938 243.962 102 464.554 240.587 103 477.170 237.212 104 486.736 246.178 105 498.653 251.642 106 511.689 253.038 107 524.494 250.223 108 535.741 243.488 109 544.268 233.529 110 549.191 221.378 111 550.000 208.292 112 546.612 195.627 113 539.378 184.694 114 529.046 176.623 115 516.686 172.252 116 503.577 172.032 117 491.077 175.985 118 480.480 183.704 119 472.882 194.389 120 469.071 206.933 121 456.454 210.307 122 443.838 213.682 123 431.221 217.057 124 418.605 220.432 125 405.989 223.807 126 393.372 227.182 127 380.756 230.557 128 355.523 237.307 129 330.290 244.057 130 317.674 247.432 131 305.058 250.806 132 303.033 243.237 133 301.008 235.667 134 298.983 228.097 135 296.958 220.527 136 294.933 212.957 137 305.966 339.514 138 305.966 326.454 139 305.966 313.394 140 305.966 300.334 141 305.966 287.274 142 329.473 261.154 143 321.638 261.154 144 313.802 261.154 145 305.966 261.154 146 305.966 248.094 147 305.966 235.034 148 305.966 221.974 149 305.966 208.914 150 305.966 195.854 151 305.966 169.734 152 305.966 156.674 153 305.966 143.614 154 305.966 130.554 155 305.966 117.494 156 305.966 104.434 157 305.966 78.314 158 305.966 52.194 159 305.966 39.134 160 305.966 26.074 161 307.732 11.199 162 297.783 0.000 163 282.804 0.000 164 272.855 11.199 165 274.622 26.074 166 274.622 39.134 167 274.622 52.194 168 274.622 65.254 169 274.622 91.374 170 274.622 130.554 171 274.622 143.614 172 274.622 156.674 173 274.622 169.734 174 266.786 169.734 175 258.950 169.734 176 251.114 169.734 177 243.278 169.734 178 235.442 169.734 179 227.606 169.734 180 274.622 287.274 181 274.622 300.334 182 274.622 313.394 183 274.622 326.454 184 274.622 339.514 185 266.786 339.514 186 274.622 365.634 187 274.622 378.694 188 274.622 391.754 189 274.622 404.814 190 274.622 417.874 191 208.292 432.814 192 195.256 433.611 193 182.220 434.408 194 169.185 435.206 195 156.149 436.003 196 143.113 436.800 197 135.292 437.278 1 22 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 1 2 3 4 5 6 AAG CCACACAAAC CAGACGGCC Crystallography ? ? Angstroms 1 A O3' 79.500 87.554 -49.929 2 A P 78.290 87.137 -48.964 O3' 74.126 89.745 -47.771 3 G P 73.079 88.828 -46.966 O3' 68.504 86.321 -49.404 4 C P 67.705 85.128 -48.693 O3' 65.694 81.569 -51.558 5 C P 65.117 80.546 -50.479 O3' 64.576 75.705 -51.385 6 A P 64.367 74.641 -50.208 O3' 66.144 69.188 -49.880 7 C P 64.819 69.025 -48.985 O3' 67.015 65.918 -44.547 8 A P 67.040 66.002 -42.944 O3' 69.262 65.930 -38.858 9 C P 68.061 66.145 -37.811 O3' 69.535 68.648 -33.247 10 A P 68.367 68.876 -32.156 O3' 67.763 72.561 -29.131 11 A P 66.636 73.638 -29.556 O3' 65.434 77.183 -25.353 12 A P 64.138 77.889 -25.987 O3' 63.979 82.497 -23.402 13 C P 62.716 83.109 -24.181 O3' 63.981 87.885 -26.540 14 C P 62.739 88.350 -27.436 O3' 63.857 90.736 -31.948 15 A P 62.358 91.222 -32.245 O3' 60.595 89.877 -37.169 16 G P 59.161 90.619 -37.088 O3' 56.735 91.976 -41.341 17 A P 55.842 93.319 -41.112 O3' 61.366 94.426 -42.201 18 C P 62.737 94.200 -41.349 O3' 67.253 95.763 -43.225 19 G P 68.386 95.296 -42.192 O3' 72.395 97.480 -40.912 20 G P 73.093 97.053 -39.553 O3' 75.286 99.723 -35.098 21 C P 75.478 98.629 -33.949 O3' 76.175 99.867 -29.170 22 C P 76.236 98.423 -28.473 O3' 74.461 98.409 -23.512 16 17 ! ! ! SG1 1 1 SG2 8 10 SG3 16 16 1 133.379 405.993 2 141.200 405.515 3 154.236 404.717 4 167.271 403.920 5 180.307 403.123 6 193.342 402.326 7 206.378 401.528 8 305.966 441.382 9 305.966 433.546 10 305.966 425.710 11 305.966 417.874 12 305.966 404.814 13 305.966 391.754 14 305.966 378.694 15 305.966 365.634 16 182.243 292.849 17 174.610 291.078 18 171.658 303.800 19 168.705 316.522 20 165.753 329.244 21 162.801 341.965 22 159.849 354.687 1 3 3 2 1 C Au 3 5MU Crystallography ? ? Angstroms 1 C O3' 52.073 105.105 -33.235 2 A P 52.597 103.643 -33.602 O3' 51.445 99.845 -37.682 3 u O3' 53.935 95.762 -40.520 P 52.057 98.581 -36.940 1 186.419 240.190 2 183.467 252.912 3 180.514 265.634 1 22 + + c 2 21 + + c 3 20 + + c 4 19 + + c 5 18 + + c 6 17 - - c 137 16 H W c 186 15 H S t 187 14 + + c 188 13 + + c 189 12 S H t 190 11 H H t 191 7 + + c 192 6 - - c 193 5 W W c 194 4 + + c 195 3 + + c 184 16 ! ! ! 185 15 ! ! ! 196 2 ! ! ! 58 2 ! ! ! 80 2 ! ! ! 196 1 ! ! ! 1 15 ! ! ! 59 1 ! ! ! 81 3 ! ! ! 1 22 6 186 15 5 191 7 6 7 3 W W c 8 2 - - c 9 1 + + c 7 2 ! ! ! 84 3 ! ! ! 7 3 3