1 75 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 AGCGCCGUgg CGCAGuGGAA GCGCgCAGGG CUCAUaACCC UGAUguccUC GGAUCGaAAC CGaGCGGCGC UACCA 9 1MG 10 2MG 16 H2U 25 M2G 36 T6A 45 7MG 46 H2U 47 5MC 48 5MC 57 1MA 63 RIA LOOP1 53 59 LOOP2 14 20 LOOP3 32 36 Crystallography ? ? Angstroms 1 A P 3.411 10.454 10.360 O3' 5.199 7.682 6.598 2 G P 5.726 8.968 5.767 O3' 5.545 9.146 0.847 3 C P 6.069 10.449 0.109 O3' 4.870 13.116 -3.490 4 G P 5.484 14.555 -3.850 O3' 4.017 19.094 -5.460 5 C P 4.957 20.343 -5.115 O3' 3.416 25.596 -4.215 6 C P 4.961 25.963 -3.884 O3' 4.519 29.859 -0.446 7 G P 5.910 30.537 -0.002 O3' 6.318 32.461 5.632 8 U P 5.893 33.996 5.440 O3' 8.270 38.371 5.987 9 g P 6.883 39.114 6.283 O3' 5.573 43.123 9.462 10 g P 5.552 42.540 10.975 O3' 0.296 40.679 11.127 11 C P 0.777 39.322 10.427 O3' -2.899 38.120 6.409 12 G P -1.969 36.940 5.805 O3' -2.677 36.331 0.392 13 C P -1.832 34.923 0.411 O3' 1.657 35.982 -3.865 14 A P 2.610 34.820 -4.452 O3' 5.872 36.501 -7.979 15 G P 6.742 35.157 -8.218 O3' 11.553 35.466 -8.756 16 u P 12.127 33.975 -8.731 O3' 17.521 33.213 -11.407 17 G P 18.717 33.128 -10.360 O3' 22.268 37.418 -8.944 18 G P 21.695 38.797 -9.741 O3' 23.690 42.874 -6.444 19 A P 22.496 43.661 -5.728 O3' 19.084 42.880 -2.032 20 A P 19.577 44.195 -1.299 O3' 14.685 47.046 -1.144 21 G P 13.941 48.193 -0.234 O3' 9.259 48.743 -3.310 22 C P 7.978 49.548 -2.751 O3' 3.302 49.265 -4.610 23 G P 2.437 50.107 -3.530 O3' -1.945 49.687 -2.876 24 C P -2.656 50.676 -1.845 O3' -5.895 50.018 1.829 25 g P -5.949 51.237 2.917 O3' -4.939 51.229 8.718 26 C P -5.081 52.780 9.175 O3' -2.161 54.627 12.773 27 A P -2.639 56.167 12.807 O3' 0.291 60.034 13.408 28 G P -0.764 61.196 13.006 O3' 1.446 65.851 10.831 29 G P 1.058 67.292 10.323 O3' 0.610 70.174 5.823 30 G P -0.155 70.880 4.593 O3' -0.601 71.541 -0.335 31 C P -1.930 72.350 0.099 O3' -3.863 73.248 -5.302 32 U P -5.099 73.576 -6.233 O3' -9.737 73.208 -8.013 33 C P -10.735 74.211 -7.218 O3' -11.857 73.936 -1.673 34 A P -11.600 73.367 -0.236 O3' -10.932 68.048 1.524 35 U P -11.141 67.704 3.082 O3' -10.706 62.056 1.810 36 a P -11.254 61.073 2.922 O3' -11.413 57.757 -0.316 37 A P -10.524 56.573 -0.796 O3' -8.050 56.667 -4.631 38 C P -7.102 55.865 -5.596 O3' -2.672 57.757 -6.761 39 C P -1.218 57.930 -7.492 O3' 3.334 60.318 -5.423 40 C P 4.045 59.018 -4.925 O3' 7.585 61.192 -1.786 41 U P 8.390 59.923 -1.844 O3' 10.574 59.646 3.501 42 G P 11.463 58.331 3.111 O3' 11.463 56.303 8.489 43 A P 12.250 54.904 8.221 O3' 11.471 52.148 11.962 44 U P 12.703 51.176 11.521 O3' 10.559 46.389 12.378 45 g P 12.021 45.664 12.341 O3' 11.832 40.472 10.702 46 u P 12.545 39.723 11.953 O3' 16.637 37.160 9.270 47 c P 15.933 37.115 7.800 O3' 11.915 33.857 4.956 48 c P 11.579 32.265 4.904 O3' 13.631 30.795 10.200 49 U P 14.838 31.576 9.471 O3' 18.452 28.587 12.522 50 C P 19.655 29.219 11.601 O3' 23.508 25.912 11.895 51 G P 24.623 26.446 10.815 O3' 27.526 23.194 7.296 52 G P 28.261 24.266 6.293 O3' 29.893 22.366 1.846 53 A P 30.669 23.499 1.032 O3' 31.059 23.693 -4.494 54 U P 32.233 24.783 -3.978 O3' 31.996 29.215 -6.646 55 C P 33.585 29.234 -6.493 O3' 32.817 32.629 -2.414 56 G P 31.698 31.512 -1.977 O3' 27.270 34.651 -0.992 57 a P 26.246 33.438 -0.524 O3' 21.474 35.683 0.470 58 A P 21.152 34.948 1.881 O3' 17.608 31.532 0.584 59 A P 18.305 30.572 -0.458 O3' 15.724 29.203 -5.165 60 C P 15.458 27.664 -5.311 O3' 18.178 23.225 -6.678 61 C P 17.072 22.507 -5.790 O3' 19.050 18.175 -3.422 62 G P 17.662 17.837 -2.748 O3' 18.384 15.138 1.651 63 a P 16.929 14.894 2.324 O3' 21.010 14.348 10.615 64 G P 14.754 14.255 7.851 O3' 12.146 17.562 11.872 65 C P 10.615 17.048 11.625 O3' 7.736 20.392 13.766 66 G P 6.190 20.061 13.524 O3' 2.408 23.259 13.065 67 G P 1.085 22.546 12.560 O3' -2.448 24.700 9.660 68 C P -3.527 23.488 9.529 O3' -6.839 23.125 4.674 69 G P -7.543 21.841 5.380 O3' -8.763 19.241 1.068 70 C P -9.407 17.822 1.286 O3' -8.477 13.323 -1.998 71 U P -9.400 12.168 -1.298 O3' -7.588 7.528 -2.216 72 A P -8.502 6.671 -1.133 O3' -11.422 2.860 -2.784 73 C P -12.078 2.649 -1.312 O3' -12.320 -2.223 1.194 74 C P -12.800 -3.716 1.035 O3' -13.325 -7.519 -3.386 75 A P -13.276 -8.882 -2.543 O3' -9.978 -11.631 -5.394 9 syn 18 syn 19 syn 36 syn 45 syn 75 syn 1 71 - - c 2 70 + + c 3 69 + + c 4 68 + + c 5 67 + + c 6 66 + + c 7 65 + + c 8 14 W H t 9 22 H H t 10 24 + + c 11 23 + + c 12 22 + + c 13 21 + + c 15 47 W W t 17 54 W S t 18 55 + + c 19 56 W S t 21 45 H W t 25 43 W W c 26 42 + + c 27 41 - - c 28 40 + + c 29 39 + + c 30 38 + + c 48 64 + + c 49 63 - - c 50 62 + + c 51 61 + + c 52 60 + + c 53 57 W H t 31 37 ! ! ! 8 20 ! ! ! 9 11 ! ! ! 7 8 ! ! ! 15 16 ! ! ! 16 17 ! ! ! 46 47 ! ! ! 59 60 ! ! ! 1 71 7 48 64 5 10 24 4 25 43 7 SG1 8 9 SG2 14 20 SG3 32 36 SG4 44 47 SG5 53 59 SG6 72 75 1 495.730 54.270 2 495.730 76.883 3 495.730 99.495 4 495.730 122.108 5 495.730 144.721 6 495.730 167.333 7 495.730 189.946 8 509.297 189.946 9 522.865 189.946 10 236.601 258.869 11 259.138 260.713 12 281.675 262.557 13 304.212 264.402 14 325.179 254.771 15 347.940 258.552 16 364.668 274.442 17 369.611 296.979 18 361.070 318.412 19 341.981 331.372 20 318.909 331.401 21 299.786 318.491 22 277.249 316.647 23 254.712 314.803 24 232.175 312.959 25 187.100 309.270 26 164.563 307.426 27 142.026 305.582 28 119.488 303.738 29 96.951 301.894 30 74.414 300.049 31 51.876 298.205 32 27.859 302.894 33 6.937 290.202 34 0.000 266.735 35 10.659 244.707 36 33.367 235.585 37 56.302 244.116 38 78.840 245.960 39 101.377 247.804 40 123.914 249.648 41 146.451 251.492 42 168.989 253.337 43 191.526 255.181 44 550.000 235.171 45 536.432 235.171 46 522.865 235.171 47 509.297 235.171 48 495.730 235.171 49 495.730 257.784 50 495.730 280.396 51 495.730 303.009 52 495.730 325.621 53 507.038 345.733 54 505.126 368.726 55 490.653 386.694 56 468.595 393.459 57 446.536 386.694 58 432.063 368.726 59 430.152 345.733 60 441.460 325.621 61 441.460 303.009 62 441.460 280.396 63 441.460 257.784 64 441.460 235.171 65 441.460 189.946 66 441.460 167.333 67 441.460 144.721 68 441.460 122.108 69 441.460 99.495 70 441.460 76.883 71 441.460 54.270 72 441.460 40.703 73 441.460 27.135 74 441.460 13.568 75 441.460 0.000