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| Title: | | CRYSTAL STRUCTURE OF D(GCGAGAGC): THE DNA QUADRUPLEX STRUCTURE SPLIT FROM THE OCTAPLEX | |
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| Molecular Description: | 5'-D(Gp(I5C)pGpApGpApGpC)-3' |
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| Structural Features: | RH QUADRUPLE HELIX, BASE INTERCALATED |
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| Nucleic Acid Sequence: |
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| Chains | A, B: | |
(DG) (I5C) (DG) (DA) (DG) (DA) (DG) (DC)
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| Primary Citation: | Kondo, J., Adachi, W., Umeda, S., Sunami, T., Takenaka, A.
Crystal structures of a DNA octaplex with I-motif of G-quartets and its splitting into two quadruplexes suggest a folding mechanism of eight tandem repeats
Nucleic Acids Res.
, 32,
pp. 2541 - 2549, 2004.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
I
2
2
2
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| Cell Constants: |
| a = 34.650 | b = 42.490 | c = 64.080 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 90.00 | (degrees) |
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| Crystallization Conditions: |
| Method: | | VAPOR DIFFUSION, HANGING DROP |
| Drop: | | 2-methyl-2,4-pentanediol, spermine tetrahydrochloride, sodium chloride, potassium chloride, sodium cacodylate |
| Reservoir: | | sodium chloride, potassium chloride, sodium cacodylate |
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| Refinement: | The structure was refined using the CNS 1.0 program.
The R value is
26.2
for 5063 reflections
in the resolution range 9.0 to
1.7 Ångstroms
with Fobs > 3.0 sigma(Fobs).
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