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| Title: | | CRYSTAL STRUCTURE ANALYSIS OF THE DNA QUADRUPLEX D(TGGGGT)S2 | |
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| Molecular Description: | 5'-D(TpGpGpGpGpT)-3' |
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| Structural Features: | QUADRUPLE HELIX, PARALLEL-STRANDED TETRAPLEX |
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| Nucleic Acid Sequence: |
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| Chains | A, B, C, D, E, F, G, H, I, J, K, L: | |
(DT) (DG) (DG) (DG) (DG) (DT)
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| Primary Citation: | Caceres, C., Wright, G., Gouyette, C., Parkinson, G., Subirana, J.A.
A Thymine tetrad in d(TGGGGT) quadruplexes stabilized with Tl+1/Na+1 ions
Nucleic Acids Res.
, 32,
pp. 1097 - 1102, 2004.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
1
21
1
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| Cell Constants: |
| a = 28.319 | b = 56.341 | c = 51.746 | (Ångstroms) |
 = 90.00 |  = 99.17 |  = 90.00 | (degrees) |
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| Crystallization Conditions: |
| Drop: | | PEG
400 sodium cacodylate, magnesium chloride, spermine, tetrahydrochlorhide, thallium acetate, lysine-anthraquinone, H2O |
| Reservoir: | | PEG
400 magnesium chloride, thallium acetate, sodium cacodylate, H2O |
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| Refinement: | The structure was refined using the CNS 1.1 program.
The R value is
22.4
for 4281 reflections
in the resolution range 19.84 to
2.50 Ångstroms
with Fobs > 2.000 sigma(Fobs).
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