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| Title: | | STRUCTURAL RATIONALIZATION OF A LARGE DIFFERENCE IN RNA AFFINITY DESPITE A SMALL DIFFERENCE IN CHEMISTRY BETWEEN TWO 2'-O-MODIFIED NUCLEIC ACID ANALOGS | |
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| Molecular Description: | 5'-D(GpCpGpTpAp(NMT)pApCpGpC)-3' |
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| Structural Features: | A DOUBLE HELIX |
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| Nucleic Acid Sequence: |
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| Chains | A,B: | | (DG) (DC) (DG) (DT) (DA) (NMT) (DA) (DC) (DG) (DC) |
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| Primary Citation: | Pattanayek, R., Sethaphong, L., Pan, C., Prhavc, M., Prakash, T.P., Manoharan, M., Egli, M.
Structural rationalization of a large difference in RNA affinity despite a small difference in chemistry between two 2'-O-modified nucleic acid analogues.
J.Am.Chem.Soc.
, 126,
pp. 15006 - 15007, 2004.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
21
21
21
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| Cell Constants: |
| a = 24.599 | b = 44.876 | c = 46.305 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 90.00 | (degrees) |
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| Refinement: | The structure was refined using the SHELXL-97 program.
The R value is
15.3
for 13637 reflections
in the resolution range 30.0 to
1.25 Ångstroms
with Fobs > 0. sigma(Fobs).
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