1 157 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 GAAUUGCGGG AAAGGGGUCA ACAGCCGUUC AGUACCAAGU CUCAGGGGAA ACUUUGAGAU GGCCUUGCAA AGGGUAUGGU AAUAAGCUGA CGGACAUGGU CCUAACACGC AGCCAAGUCC UAAGUCAACA GAUCUUCUGU UGAUAUGGAU GCAGUUC LOOP1 48 51 LOOP2 66 70 LOOP3 133 135 Crystallography ? ? Angstroms 1 G O3' 104.409 39.353 27.450 2 A P 103.488 39.517 28.777 O3' 102.712 34.993 30.139 3 A P 102.558 33.746 31.096 O3' 99.773 32.179 35.347 4 U P 100.390 33.571 35.925 O3' 96.800 35.154 39.821 5 U P 95.293 34.938 40.301 O3' 91.493 38.255 42.558 6 G P 89.914 38.085 42.706 O3' 85.718 41.897 43.024 7 C P 84.192 41.655 42.601 O3' 80.945 45.381 39.747 8 G P 79.521 44.812 39.317 O3' 77.017 47.197 35.619 9 G P 75.638 46.382 35.686 O3' 72.924 46.064 30.972 10 G P 71.781 44.950 31.122 O3' 71.070 41.270 27.336 11 A P 69.957 40.196 27.759 O3' 70.511 35.227 26.411 12 A P 69.528 34.088 26.983 O3' 69.644 29.309 25.171 13 A P 68.191 28.865 25.690 O3' 67.517 24.603 27.919 14 G P 66.088 24.561 28.638 O3' 64.554 22.236 33.653 15 G P 63.050 22.686 33.990 O3' 61.963 23.453 38.772 16 G P 60.497 24.086 38.566 O3' 59.054 27.489 42.098 17 G P 57.676 28.093 41.534 O3' 55.640 32.651 42.944 18 U P 54.218 32.927 42.252 O3' 52.460 37.325 40.022 19 C P 51.047 37.123 39.281 O3' 49.158 39.923 35.361 20 A P 47.743 39.178 35.189 O3' 44.323 39.987 32.198 21 A P 44.226 41.472 31.590 O3' 47.868 46.143 31.785 22 C P 47.324 46.452 33.281 O3' 51.924 47.641 36.361 23 A P 52.638 47.723 37.808 O3' 57.609 49.927 39.576 24 G P 58.400 49.338 38.318 O3' 61.871 46.486 36.707 25 C P 62.586 47.341 35.554 O3' 64.159 46.200 30.839 26 C P 64.788 47.605 30.388 O3' 64.339 49.366 25.500 27 G P 65.161 50.734 25.626 O3' 63.142 53.870 21.603 28 U P 63.092 55.362 20.997 O3' 65.337 60.600 21.746 29 U P 64.264 60.869 22.914 O3' 61.495 63.898 23.239 30 C P 62.220 64.764 24.383 O3' 59.888 67.517 27.976 31 A P 61.053 68.181 28.868 O3' 60.733 69.417 33.766 32 G P 62.133 69.912 34.373 O3' 63.617 69.333 39.250 33 U P 65.142 69.664 39.651 O3' 68.118 67.790 43.152 34 A P 69.476 68.602 42.877 O3' 74.068 66.117 43.862 35 C P 75.202 67.130 43.355 O3' 79.450 64.938 40.803 36 C P 80.506 66.056 40.317 O3' 83.424 65.059 35.582 37 A P 84.943 65.516 35.714 O3' 87.813 61.733 37.561 38 A P 89.242 62.053 36.896 O3' 92.217 58.285 34.795 39 G P 93.579 59.118 34.569 O3' 96.004 59.560 30.113 40 U P 97.146 60.661 30.392 O3' 98.631 64.166 26.942 41 C P 99.817 64.861 27.786 O3' 100.521 69.894 26.398 42 U P 101.751 70.452 27.282 O3' 102.021 75.257 28.714 43 C P 103.280 75.374 29.707 O3' 103.220 78.579 33.750 44 A P 104.547 78.298 34.619 O3' 104.698 78.717 39.804 45 G P 106.124 78.108 40.250 O3' 107.273 75.766 44.811 46 G P 108.651 74.948 44.652 O3' 109.959 70.797 46.966 47 G P 111.443 70.645 46.370 O3' 113.602 66.077 45.801 48 G P 115.046 66.659 45.391 O3' 117.878 64.534 41.706 49 A P 119.072 65.613 41.715 O3' 118.623 68.339 37.021 50 A P 117.026 68.504 36.916 O3' 115.404 67.301 31.800 51 A P 113.805 67.318 31.609 O3' 111.380 63.028 29.137 52 C P 109.853 63.491 29.138 O3' 106.715 60.609 32.927 53 U P 105.263 60.999 33.524 O3' 103.931 60.370 38.566 54 U P 102.345 60.676 38.521 O3' 100.328 62.564 42.834 55 U P 98.811 62.881 42.408 O3' 96.253 66.665 44.604 56 G P 94.891 66.995 43.831 O3' 92.841 71.664 43.322 57 A P 91.596 71.645 42.315 O3' 90.326 75.707 39.345 58 G P 89.122 75.171 38.423 O3' 88.653 76.823 33.407 59 A P 87.484 75.916 32.767 O3' 87.998 74.773 27.466 60 U P 86.802 73.861 26.909 O3' 87.724 69.842 23.697 61 G P 86.233 69.255 23.553 O3' 86.053 63.811 23.821 62 G P 84.605 63.386 23.240 O3' 81.804 59.452 26.345 63 C P 80.993 58.362 25.492 O3' 76.108 58.624 23.662 64 C P 76.301 57.116 23.177 O3' 74.413 55.994 18.164 65 U P 74.541 54.436 18.566 O3' 78.889 53.528 22.107 66 U P 78.320 52.485 23.186 O3' 78.523 46.995 21.360 67 G P 79.253 46.801 19.950 O3' 83.504 47.832 22.592 68 C P 83.481 49.436 22.630 O3' 87.166 52.649 22.983 69 A P 86.741 54.205 22.898 O3' 88.309 58.131 18.316 70 A P 89.784 58.570 18.826 O3' 91.145 61.824 15.105 71 A P 89.937 62.884 15.242 O3' 87.850 64.949 11.034 72 G P 86.950 66.060 11.764 O3' 82.333 67.365 10.227 73 G P 82.167 68.630 11.205 O3' 77.758 69.654 13.662 74 G P 78.043 70.632 14.900 O3' 76.058 70.332 19.554 75 U P 76.645 71.641 20.285 O3' 78.354 71.589 25.214 76 A P 78.226 73.189 25.292 O3' 73.736 73.992 29.214 77 U P 72.771 75.104 28.595 O3' 70.172 70.743 26.220 78 G P 70.598 69.568 25.231 O3' 73.971 66.569 23.843 79 G P 73.373 65.119 24.193 O3' 75.891 61.114 27.555 80 U P 75.145 59.816 28.123 O3' 77.748 57.337 32.681 81 A P 78.800 56.263 32.178 O3' 78.918 53.042 35.206 82 A P 80.389 53.420 35.725 O3' 83.780 50.524 38.043 83 U P 85.017 51.495 38.363 O3' 83.682 56.957 37.240 84 A P 82.144 57.117 36.823 O3' 78.759 59.795 38.542 85 A P 77.876 58.522 38.995 O3' 73.409 55.579 38.977 86 G P 74.469 54.674 38.194 O3' 69.998 54.458 34.832 87 C P 69.025 53.312 35.384 O3' 66.859 54.275 39.791 88 U P 65.345 53.822 39.546 O3' 61.403 56.013 41.751 89 G P 60.070 55.294 41.211 O3' 55.543 57.961 38.778 90 A P 54.439 57.184 37.911 O3' 51.499 59.632 34.454 91 C P 50.670 58.468 33.707 O3' 49.609 58.207 28.698 92 G P 48.985 56.749 28.442 O3' 50.082 54.056 24.098 93 G P 49.501 52.559 24.200 O3' 52.108 48.767 21.647 94 A P 51.512 47.283 21.821 O3' 54.227 43.224 21.058 95 C P 53.121 42.059 21.102 O3' 53.162 36.858 23.732 96 A P 52.230 36.619 22.438 O3' 51.606 31.286 22.281 97 U P 51.900 29.707 22.466 O3' 56.787 29.547 23.192 98 G P 58.064 29.911 24.123 O3' 59.701 35.460 24.916 99 G P 60.770 35.974 25.990 O3' 60.770 40.528 28.050 100 U P 62.188 40.431 28.800 O3' 62.957 41.929 33.594 101 C P 64.428 41.504 34.082 O3' 65.960 40.574 38.761 102 C P 67.442 40.004 38.541 O3' 69.804 37.004 41.755 103 U P 71.215 36.963 40.990 O3' 73.903 32.508 40.646 104 A P 75.161 33.273 39.993 O3' 77.802 31.746 35.216 105 A P 79.401 31.858 35.311 O3' 81.488 28.453 31.859 106 C P 82.722 29.346 31.354 O3' 83.027 31.109 26.474 107 A P 84.371 31.974 26.455 O3' 84.550 36.085 23.033 108 C P 85.855 36.920 23.436 O3' 85.783 42.228 23.558 109 G P 87.111 42.819 24.267 O3' 86.604 47.659 26.381 110 C P 88.027 48.107 26.959 O3' 88.543 51.330 30.951 111 A P 90.119 51.374 31.262 O3' 92.479 52.250 35.653 112 G P 94.016 52.253 35.181 O3' 97.414 49.647 38.625 113 C P 98.935 49.594 38.103 O3' 102.333 45.236 39.243 114 C P 103.838 45.501 38.710 O3' 108.293 42.323 36.922 115 A P 109.409 43.225 36.184 O3' 113.033 41.784 33.339 116 A P 113.604 42.499 32.005 O3' 114.200 41.299 27.271 117 G P 115.084 42.553 26.850 O3' 114.256 44.815 22.258 118 U P 115.256 46.069 22.211 O3' 113.655 50.540 20.139 119 C P 114.841 51.601 20.346 O3' 113.571 56.667 21.319 120 C P 114.825 57.558 21.760 O3' 114.993 61.555 24.812 121 U P 116.568 61.909 24.687 O3' 118.913 63.835 28.921 122 A P 120.446 64.068 28.500 O3' 124.465 62.926 32.198 123 A P 124.732 64.397 32.761 O3' 127.063 64.148 37.510 124 G P 128.589 63.905 37.051 O3' 131.369 59.817 38.509 125 U P 132.713 60.072 37.668 O3' 134.993 56.259 35.245 126 C P 136.271 56.955 34.584 O3' 138.295 55.043 30.238 127 A P 139.354 56.127 29.702 O3' 140.285 56.942 24.836 128 A P 141.275 58.185 24.610 O3' 141.550 61.204 20.611 129 C P 142.707 62.232 21.049 O3' 142.163 67.298 19.566 130 A P 143.217 68.290 20.265 O3' 142.352 73.155 21.456 131 G P 143.585 73.784 22.273 O3' 143.073 77.615 25.693 132 A P 144.483 78.008 26.358 O3' 145.362 79.275 32.010 133 U P 146.943 79.342 32.286 O3' 148.430 74.616 34.759 134 C P 147.678 73.529 33.841 O3' 149.322 68.875 35.388 135 U P 149.090 69.229 36.944 O3' 147.938 63.833 36.514 136 U P 147.714 62.954 37.839 O3' 142.434 65.241 38.856 137 C P 140.887 65.293 38.415 O3' 137.140 69.665 37.829 138 U P 135.793 69.131 37.144 O3' 133.089 71.998 33.890 139 G P 132.023 71.078 33.121 O3' 130.491 72.390 28.294 140 U P 129.385 71.326 27.828 O3' 128.680 69.952 22.980 141 U P 127.532 68.837 23.086 O3' 127.613 64.860 20.017 142 G P 126.465 63.880 20.548 O3' 126.836 58.816 20.057 143 A P 125.588 58.210 20.874 O3' 125.888 53.517 22.974 144 U P 124.424 53.252 23.578 O3' 123.916 50.991 28.073 145 A P 122.363 51.022 28.442 O3' 120.638 49.201 33.637 146 U P 119.814 48.775 34.924 O3' 118.449 50.976 38.952 147 G P 117.097 51.456 38.242 O3' 114.664 55.377 39.035 148 G P 113.156 54.909 38.797 O3' 109.145 57.093 35.307 149 A P 107.843 56.174 35.428 O3' 104.683 56.527 31.326 150 U P 103.551 55.410 31.517 O3' 101.790 52.810 27.277 151 G P 100.629 51.908 27.942 O3' 96.191 53.330 25.520 152 C P 95.424 51.921 25.489 O3' 93.013 50.827 20.921 153 A P 92.366 49.391 21.236 O3' 92.623 45.496 17.960 154 G P 91.838 44.373 18.800 O3' 93.741 39.728 19.216 155 U P 92.911 38.827 20.260 O3' 95.121 34.905 23.798 156 U P 93.928 34.221 24.613 O3' 94.492 32.144 28.576 157 C P 93.248 32.153 29.593 O3' 91.489 33.300 34.480 3 syn 85 syn 86 syn 4 112 W W c 4 156 H W c 5 111 - - c 6 110 + + c 7 109 + + c 8 108 + + c 9 107 W W c 10 106 + + c 11 105 S H t 12 104 H S t 14 103 W W c 15 102 + + c 16 101 + + c 17 100 W W c 18 99 W W c 19 98 + + c 21 96 W H t 22 99 W S t 24 94 W W c 25 93 + + c 26 92 + + c 27 91 + + c 30 89 + + c 31 88 - - c 32 87 + + c 33 85 W H c 34 80 - - c 35 79 + + c 36 78 + + c 37 62 H S t 38 61 H S t 39 60 W W c 40 59 - - c 41 58 + + c 42 57 - - c 43 56 + + c 44 55 - - c 45 54 W W c 46 53 W W c 47 52 + + c 48 51 S H t 49 145 W W t 51 147 S S t 63 73 + + c 64 72 + + c 66 86 H W t 69 70 S H c 79 84 S S t 82 109 S S t 95 98 s S c 114 115 S H c 117 150 W W c 118 149 - - c 119 148 + + c 120 147 + + c 121 145 W H t 122 123 S H c 123 146 W W c 124 144 W W c 125 143 - - c 126 142 + + c 127 141 - - c 128 140 - - c 129 139 + + c 130 138 - - c 131 137 + + c 132 136 - - c 21 98 ! ! ! 65 71 ! ! ! 111 157 ! ! ! 124 146 ! ! ! 9 66 ! ! ! 19 21 ! ! ! 50 147 ! ! ! 1 115 ! ! ! 3 4 ! ! ! 8 81 ! ! ! 24 100 ! ! ! 36 37 ! ! ! 50 121 ! ! ! 51 120 ! ! ! 52 148 ! ! ! 61 75 ! ! ! 77 78 ! ! ! 82 84 ! ! ! 85 86 ! ! ! 112 157 ! ! ! 4 112 9 14 103 6 24 94 4 30 89 3 34 80 3 37 62 11 63 73 3 117 150 4 124 144 9 SG1 1 3 SG2 13 13 SG3 20 23 SG4 28 29 SG5 33 33 SG6 48 51 SG7 66 70 SG8 74 77 SG9 81 86 SG10 90 90 SG11 95 97 SG12 113 116 SG13 121 123 SG14 133 135 SG15 145 146 SG16 151 157 1 23.937 261.379 2 23.937 270.015 3 23.937 278.652 4 23.937 287.288 5 23.937 301.682 6 23.937 316.076 7 23.937 330.470 8 23.937 344.864 9 23.937 359.258 10 23.937 373.651 11 23.937 388.045 12 23.937 402.439 13 23.937 416.833 14 23.937 431.227 15 23.937 445.621 16 23.937 460.015 17 23.937 474.409 18 23.937 488.803 19 23.937 503.197 20 23.937 511.833 21 23.937 520.469 22 23.937 529.106 23 23.937 537.742 24 76.286 530.482 25 84.418 518.606 26 92.551 506.729 27 100.683 494.853 28 108.815 482.977 29 125.080 459.224 30 133.212 447.347 31 141.345 435.471 32 149.477 423.595 33 157.610 411.718 34 214.536 328.583 35 222.669 316.707 36 230.801 304.830 37 169.823 332.579 38 168.348 318.260 39 166.873 303.942 40 165.398 289.624 41 163.923 275.306 42 162.448 260.988 43 160.973 246.670 44 159.498 232.352 45 158.023 218.033 46 156.548 203.715 47 155.073 189.397 48 151.457 173.288 49 161.099 159.887 50 177.522 158.195 51 189.693 169.350 52 189.437 185.857 53 190.912 200.175 54 192.387 214.494 55 193.862 228.812 56 195.337 243.130 57 196.812 257.448 58 198.287 271.766 59 199.762 286.084 60 201.237 300.402 61 202.712 314.721 62 204.186 329.039 63 178.377 318.072 64 164.058 316.607 65 149.739 315.142 66 135.253 309.416 67 120.684 314.928 68 113.615 328.808 69 117.726 343.833 70 130.877 352.181 71 146.223 349.508 72 160.542 350.973 73 174.861 352.438 74 278.822 295.845 75 273.943 302.971 76 269.063 310.097 77 264.184 317.222 78 259.304 324.348 79 251.172 336.225 80 243.040 348.101 81 234.907 359.977 82 226.775 371.854 83 218.642 383.730 84 210.510 395.607 85 202.378 407.483 86 194.245 419.359 87 177.981 443.112 88 169.848 454.989 89 161.716 466.865 90 145.451 490.618 91 129.186 514.371 92 121.054 526.247 93 112.922 538.124 94 104.789 550.000 95 58.482 529.106 96 58.482 520.469 97 58.482 511.833 98 58.482 503.197 99 58.482 488.803 100 58.482 474.409 101 58.482 460.015 102 58.482 445.621 103 58.482 431.227 104 58.482 402.439 105 58.482 388.045 106 58.482 373.651 107 58.482 359.258 108 58.482 344.864 109 58.482 330.470 110 58.482 316.076 111 58.482 301.682 112 58.482 287.288 113 58.482 278.652 114 58.482 270.015 115 58.482 261.379 116 58.482 252.743 117 10.933 203.979 118 19.948 192.758 119 28.963 181.537 120 37.978 170.315 121 46.993 159.094 122 65.024 136.652 123 83.054 114.210 124 92.069 102.989 125 101.084 91.768 126 110.099 80.547 127 119.114 69.326 128 128.130 58.105 129 137.145 46.884 130 146.160 35.663 131 155.175 24.442 132 164.190 13.221 133 176.565 0.000 134 194.387 3.214 135 201.364 19.924 136 191.121 34.857 137 182.105 46.078 138 173.090 57.299 139 164.075 68.520 140 155.060 79.741 141 146.045 90.962 142 137.030 102.183 143 128.015 113.404 144 119.000 124.625 145 100.969 147.068 146 82.939 169.510 147 64.909 191.952 148 55.894 203.173 149 46.879 214.394 150 37.864 225.615 151 32.454 232.348 152 27.045 239.080 153 21.636 245.813 154 16.227 252.546 155 10.818 259.278 156 5.409 266.011 157 0.000 272.743