1 120 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 GCGAGCCUAG CGAAGUCAUA AGCUAGGGCA GUCUUUAGAG GCUGACGGCA GGAAAAAGAG UAUCCUUGAA AGUGCCACAG UGACGAAGUC UCGAGAGUGG AACGCGGUAA ACCCCUCGCA LOOP1 12 21 LOOP2 35 38 LOOP3 55 61 LOOP4 93 92 Crystallography ? ? Angstroms 1 G P 72.774 29.647 15.120 O3' 73.054 33.281 18.363 2 C P 71.829 33.954 17.574 O3' 72.274 39.023 16.398 3 G P 71.003 39.367 15.474 O3' 71.469 42.222 10.839 4 A P 70.205 42.162 9.848 O3' 70.220 43.115 4.823 5 G P 68.632 43.150 4.680 O3' 67.006 41.634 -0.271 6 C P 67.461 43.027 -0.955 O3' 67.519 41.604 -5.732 7 C P 68.919 41.957 -6.445 O3' 70.441 43.068 -10.836 8 U P 71.982 43.376 -10.554 O3' 74.965 46.557 -13.071 9 A P 76.365 46.309 -12.316 O3' 79.893 49.933 -11.940 10 G P 80.933 49.337 -10.866 O3' 83.877 52.449 -8.120 11 C P 84.791 51.566 -7.139 O3' 86.290 53.797 -2.595 12 G P 87.296 52.683 -2.047 O3' 86.409 50.820 2.808 13 A P 87.689 49.865 2.978 O3' 88.833 49.648 7.800 14 A P 90.223 49.572 8.601 O3' 94.175 46.158 6.620 15 G P 94.643 44.903 7.485 O3' 93.263 45.664 3.404 16 U P 92.499 47.033 2.987 O3' 92.921 46.123 -1.814 17 C P 92.035 46.763 -3.022 O3' 91.130 43.880 -6.233 18 A P 89.576 43.717 -6.560 O3' 85.572 40.822 -6.161 19 U P 84.293 41.635 -5.627 O3' 80.886 40.689 -1.208 20 A P 79.832 41.891 -1.295 O3' 77.194 42.512 2.800 21 A P 76.225 43.754 2.508 O3' 73.766 45.792 6.452 22 G P 73.037 47.086 5.842 O3' 74.116 51.831 6.698 23 C P 73.173 52.648 5.685 O3' 74.336 57.118 3.493 24 U P 73.262 57.670 2.422 O3' 73.541 59.997 -1.933 25 A P 72.061 60.211 -2.547 O3' 70.554 60.243 -7.343 26 G P 69.001 59.849 -7.413 O3' 66.758 57.972 -11.597 27 G P 65.281 57.803 -10.979 O3' 62.420 53.888 -13.137 28 G P 60.937 53.793 -12.524 O3' 58.166 49.758 -12.085 29 C P 56.865 50.309 -11.305 O3' 54.102 47.458 -8.221 30 A P 52.847 48.271 -7.631 O3' 50.682 47.461 -3.009 31 G P 49.731 48.716 -2.664 O3' 49.186 50.875 2.053 32 U P 48.260 52.157 1.769 O3' 49.126 56.554 4.745 33 C P 48.243 57.854 4.388 O3' 49.190 62.690 5.653 34 U P 47.927 63.386 4.927 O3' 47.903 67.593 2.266 35 U P 46.443 67.808 1.622 O3' 44.890 69.405 -2.887 36 U P 43.318 69.420 -2.498 O3' 41.739 64.916 -4.381 37 A P 43.032 64.066 -3.932 O3' 45.326 60.901 -7.554 38 G P 46.652 60.414 -6.787 O3' 50.934 61.825 -9.373 39 A P 52.524 61.528 -9.283 O3' 56.896 63.831 -10.213 40 G P 57.877 62.840 -9.412 O3' 60.176 64.680 -4.935 41 G P 60.928 63.520 -4.111 O3' 61.646 62.851 0.832 42 C P 62.483 61.483 0.743 O3' 61.828 58.349 5.025 43 U P 62.803 57.086 4.818 O3' 61.915 52.508 6.917 44 G P 63.170 51.640 6.405 O3' 61.829 46.703 5.448 45 A P 63.341 46.366 5.868 O3' 59.896 43.009 4.898 46 C P 59.811 41.736 3.910 O3' 62.251 40.160 -0.608 47 G P 63.249 39.317 0.341 O3' 63.238 35.752 -3.303 48 G P 61.705 35.387 -3.084 O3' 60.202 30.499 -2.866 49 C P 58.646 30.837 -2.954 O3' 53.704 28.032 -1.844 50 A P 54.232 26.803 -2.762 O3' 53.169 27.859 -7.380 51 G P 51.918 26.888 -7.666 O3' 50.818 24.418 -11.929 52 G P 49.604 23.412 -11.644 O3' 48.973 18.557 -13.805 53 A P 47.988 17.402 -13.253 O3' 48.668 12.442 -14.711 54 A P 47.419 11.562 -14.215 O3' 47.108 7.070 -10.500 55 A P 45.522 6.872 -10.659 O3' 45.308 3.271 -9.257 56 A P 44.384 1.948 -9.135 O3' 45.804 -2.522 -6.892 57 A P 44.883 -3.833 -6.715 O3' 43.942 -7.421 -2.209 58 G P 38.553 8.052 1.396 O3' 42.784 5.479 2.199 59 A P 43.825 6.702 2.103 O3' 41.398 11.674 0.033 60 G P 40.383 12.345 -1.030 O3' 45.027 13.261 -2.103 61 U P 45.923 14.449 -1.503 O3' 49.810 11.861 1.139 62 A P 51.300 11.760 0.536 O3' 54.079 7.659 1.081 63 U P 55.565 8.134 0.722 O3' 58.369 7.468 -4.264 64 C P 59.505 8.475 -4.783 O3' 60.368 9.293 -9.690 65 C P 61.388 10.528 -9.726 O3' 61.589 13.825 -13.501 66 U P 62.792 14.866 -13.276 O3' 63.263 19.495 -15.599 67 U P 64.666 20.092 -15.095 O3' 65.471 25.170 -14.363 68 G P 67.009 25.129 -13.912 O3' 68.518 28.042 -10.134 69 A P 69.993 27.411 -10.022 O3' 70.031 24.928 -5.484 70 A P 68.678 24.093 -5.500 O3' 65.673 23.958 -0.997 71 A P 64.631 22.857 -1.515 O3' 58.916 22.610 -0.713 72 G P 58.765 21.021 -0.857 O3' 58.183 18.035 3.649 73 U P 56.599 18.115 3.917 O3' 54.852 18.236 8.487 74 G P 53.306 18.563 8.698 O3' 50.876 22.336 12.160 75 C P 49.275 22.241 12.097 O3' 46.904 26.491 13.835 76 C P 45.358 26.412 13.418 O3' 41.722 29.003 12.178 77 A P 41.059 27.583 12.547 O3' 39.226 26.260 17.252 78 C P 37.744 25.784 16.833 O3' 33.479 26.400 18.705 79 A P 32.941 25.390 17.581 O3' 29.606 26.950 13.933 80 G P 29.235 25.527 13.287 O3' 29.633 23.640 8.695 81 U P 29.365 22.150 9.232 O3' 34.174 19.725 8.801 82 G P 35.058 20.887 9.463 O3' 39.491 22.042 6.101 83 A P 40.323 22.766 7.263 O3' 44.613 25.407 6.259 84 C P 45.337 24.074 5.776 O3' 48.307 24.150 2.080 85 G P 49.052 23.365 0.862 O3' 47.325 19.360 -2.118 86 A P 47.230 19.949 -3.610 O3' 41.790 19.358 -5.406 87 A P 40.568 18.357 -5.133 O3' 39.319 17.018 -0.076 88 G P 37.768 16.630 -0.247 O3' 32.837 19.042 1.568 89 U P 32.724 17.454 1.812 O3' 26.888 17.357 1.881 90 C P 26.121 17.020 0.510 O3' 21.142 18.892 0.165 91 U P 20.578 18.533 -1.294 O3' 18.097 21.042 -4.728 92 C P 17.954 19.938 -5.889 O3' 16.700 21.772 -10.709 93 G P 33.083 27.223 -12.693 O3' 29.433 30.584 -13.638 94 A P 29.283 31.507 -12.328 O3' 25.437 33.338 -9.785 95 G P 25.947 33.845 -8.349 O3' 23.523 33.669 -4.119 96 A P 24.396 34.213 -2.886 O3' 23.105 32.764 1.944 97 G P 24.217 33.099 3.055 O3' 24.465 30.486 7.303 98 U P 25.248 31.734 7.945 O3' 29.261 31.185 10.835 99 G P 29.264 32.768 11.105 O3' 33.723 35.357 11.527 100 G P 33.416 36.932 11.460 O3' 34.291 38.310 6.199 101 A P 34.247 37.142 5.104 O3' 38.382 35.167 1.473 102 A P 37.215 34.599 0.530 O3' 36.953 30.240 -1.915 103 C P 37.492 31.121 -3.119 O3' 40.789 28.143 -6.317 104 G P 40.516 29.378 -7.309 O3' 44.855 32.850 -8.569 105 C P 45.015 34.313 -9.238 O3' 47.755 31.436 -6.922 106 G P 47.632 30.821 -5.441 O3' 48.234 34.809 -1.529 107 G P 49.690 35.058 -0.919 O3' 50.337 37.308 3.293 108 U P 51.907 37.308 3.578 O3' 54.458 36.924 7.861 109 A P 55.961 37.189 7.360 O3' 59.624 35.094 9.063 110 A P 61.088 35.738 9.306 O3' 58.010 36.281 12.205 111 A P 56.433 35.982 12.285 O3' 59.516 31.736 13.419 112 C P 61.054 31.480 13.036 O3' 63.089 26.840 13.936 113 C P 64.525 27.403 13.536 O3' 66.532 24.378 9.528 114 C P 67.798 24.618 8.574 O3' 68.998 24.227 3.919 115 C P 70.416 24.926 3.625 O3' 72.359 26.916 -0.431 116 U P 73.866 27.290 -0.033 O3' 76.660 31.350 -1.552 117 C P 77.944 31.061 -0.621 O3' 80.285 35.225 1.192 118 G P 81.400 35.106 2.350 O3' 83.336 38.224 5.318 119 C P 84.308 37.514 6.363 O3' 85.276 38.616 11.211 120 A P 86.130 37.446 11.896 O3' 86.476 35.546 16.407 60 syn 71 syn 83 syn 102 syn 1 119 + + c 2 118 + + c 3 117 + + c 4 116 - - c 5 115 + + c 6 27 + + c 7 26 + + c 8 25 - - c 9 24 - - c 10 23 + + c 11 22 + + c 13 19 H W t 15 18 S W t 28 46 + + c 29 44 + + c 30 43 - - c 31 42 + + c 32 41 W W c 33 40 + + c 47 70 S S t 47 114 + + c 48 113 + + c 49 111 W H t 50 66 - - c 51 65 + + c 52 64 + + c 53 63 - - c 54 62 S H t 54 86 H H t 67 71 W W t 72 112 + + c 73 111 - - c 74 108 W W c 75 107 + + c 76 106 + + c 79 83 W H t 80 102 S W t 82 87 S W c 82 97 W W t 83 84 S H c 85 103 H W c 89 96 - - c 90 95 + + c 91 94 W W c 92 93 + + c 102 103 S H c 109 112 S H c 34 39 ! ! ! 79 102 ! ! ! 84 104 ! ! ! 98 102 ! ! ! 12 21 ! ! ! 57 58 ! ! ! 68 70 ! ! ! 76 101 ! ! ! 80 97 ! ! ! 81 88 ! ! ! 14 15 ! ! ! 15 119 ! ! ! 45 46 ! ! ! 49 50 ! ! ! 55 60 ! ! ! 60 61 ! ! ! 69 115 ! ! ! 70 114 ! ! ! 71 72 ! ! ! 76 77 ! ! ! 79 98 ! ! ! 80 98 ! ! ! 86 87 ! ! ! 99 101 ! ! ! 109 110 ! ! ! 1 119 5 47 114 2 72 112 2 74 108 3 6 27 6 29 44 6 50 66 5 89 96 4 SG1 12 21 SG2 28 28 SG3 35 38 SG4 45 46 SG5 49 49 SG6 55 61 SG7 67 71 SG8 77 88 SG9 97 105 SG10 109 110 SG11 120 120 1 143.991 55.330 2 143.991 76.438 3 143.991 97.546 4 143.991 118.654 5 143.991 139.762 6 356.357 183.415 7 346.505 164.747 8 336.653 146.080 9 326.801 127.412 10 316.948 108.744 11 307.096 90.077 12 287.250 83.178 13 272.594 68.123 14 266.231 48.098 15 269.508 27.344 16 281.731 10.255 17 300.313 0.448 18 321.320 0.000 19 340.303 9.006 20 353.244 25.559 21 357.403 46.154 22 351.899 66.432 23 361.751 85.099 24 371.603 103.767 25 381.455 122.435 26 391.307 141.102 27 401.159 159.770 28 412.360 153.859 29 420.863 197.105 30 430.715 215.773 31 440.567 234.440 32 450.420 253.108 33 460.272 271.776 34 470.124 290.443 35 483.870 310.373 36 478.098 333.886 37 456.687 345.186 38 434.018 336.683 39 425.321 314.088 40 415.469 295.421 41 405.617 276.753 42 395.765 258.085 43 385.913 239.418 44 376.061 220.750 45 118.662 181.977 46 131.327 181.977 47 143.991 181.977 48 143.991 203.085 49 131.327 203.085 50 99.465 262.919 51 92.044 282.680 52 84.624 302.440 53 77.203 322.201 54 69.782 341.961 55 73.064 363.247 56 63.848 382.713 57 45.304 393.665 58 23.807 392.338 59 6.751 379.187 60 0.000 358.736 61 5.875 338.015 62 22.357 324.152 63 29.778 304.391 64 37.199 284.631 65 44.619 264.870 66 52.040 245.110 67 80.668 245.301 68 93.332 245.301 69 105.997 245.301 70 118.662 245.301 71 131.327 245.301 72 143.991 245.301 73 143.991 266.409 74 143.991 329.733 75 143.991 350.841 76 143.991 371.949 77 143.991 384.614 78 143.991 397.278 79 143.991 409.943 80 143.991 422.608 81 143.991 435.273 82 143.991 447.937 83 143.991 460.602 84 143.991 473.267 85 143.991 485.932 86 143.991 498.596 87 143.991 511.261 88 143.991 523.926 89 137.314 474.321 90 119.086 484.965 91 100.859 495.610 92 82.632 506.254 93 108.178 550.000 94 126.406 539.355 95 144.633 528.711 96 162.861 518.066 97 194.650 485.932 98 194.650 473.267 99 194.650 460.602 100 194.650 447.937 101 194.650 435.273 102 194.650 422.608 103 194.650 409.943 104 194.650 397.278 105 194.650 384.614 106 194.650 371.949 107 194.650 350.841 108 194.650 329.733 109 194.650 308.625 110 194.650 287.517 111 194.650 266.409 112 194.650 245.301 113 194.650 203.085 114 194.650 181.977 115 194.650 139.762 116 194.650 118.654 117 194.650 97.546 118 194.650 76.438 119 194.650 55.330 120 194.650 42.665