1 155 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 GGUGCCAGGU AACGCCUGGG CGGGGUAACC CGACGGAAAG UGCCACAGAG AAGAGACCGC CAGCGGCCGG GGCCCCGGUG CGGGCAAGGG UGAAACGGCG GGGUAAGAGC CCACCGCCUG GCCUGGCAAC AGGCCGGGGC ACGGCAAACC CCACC LOOP1 10 14 LOOP2 25 28 LOOP3 73 72 LOOP4 103 109 LOOP5 126 129 Crystallography ? ? Angstroms 1 G P 38.855 -23.831 114.161 O3' 35.611 -22.849 110.405 2 G P 36.735 -22.852 109.249 O3' 37.053 -18.824 105.604 3 U P 38.440 -18.688 104.799 O3' 40.493 -14.038 102.987 4 G P 41.988 -14.183 102.398 O3' 45.837 -10.678 102.631 5 C P 45.751 -9.063 102.691 O3' 47.400 -5.679 104.834 6 C P 46.209 -4.626 105.012 O3' 46.023 1.215 104.467 7 A P 44.621 1.888 104.893 O3' 42.643 6.403 103.138 8 G P 41.064 6.514 103.410 O3' 38.117 9.248 100.211 9 G P 36.665 9.105 100.884 O3' 32.370 8.690 98.219 10 U P 31.443 9.035 99.487 O3' 28.141 5.683 101.278 11 A P 27.604 6.795 102.313 O3' 29.895 5.086 106.746 12 A P 31.155 4.356 106.055 O3' 32.665 -1.259 106.142 13 C P 34.153 -0.981 105.603 O3' 35.660 -5.037 102.502 14 G P 37.044 -5.141 101.700 O3' 36.636 -8.213 97.009 15 C P 35.515 -8.945 96.108 O3' 34.051 -6.745 92.748 16 C P 35.426 -6.520 91.932 O3' 36.525 -2.518 89.043 17 U P 38.008 -2.168 88.533 O3' 40.633 1.632 87.881 18 G P 41.869 0.628 87.677 O3' 46.187 3.441 89.678 19 G P 47.597 2.682 89.541 O3' 51.755 3.042 92.622 20 G P 52.880 1.892 92.439 O3' 55.811 0.051 95.896 21 C P 56.843 -0.793 95.006 O3' 58.653 -5.366 96.486 22 G P 59.441 -5.967 95.237 O3' 60.137 -10.806 94.247 23 G P 60.783 -10.798 92.782 O3' 60.090 -14.358 89.204 24 G P 60.921 -13.920 87.891 O3' 59.947 -14.790 83.227 25 G P 61.128 -13.906 82.585 O3' 60.822 -11.117 78.350 26 U P 62.338 -10.586 78.482 O3' 62.033 -5.174 79.405 27 A P 60.888 -5.188 80.523 O3' 56.860 -1.503 79.124 28 A P 55.696 -1.520 80.241 O3' 50.509 -0.938 78.747 29 C P 49.671 -1.209 80.092 O3' 47.126 -6.031 80.475 30 C P 46.435 -6.514 81.846 O3' 46.048 -11.479 83.366 31 C P 45.401 -11.617 84.826 O3' 45.894 -14.945 88.135 32 G P 45.079 -14.598 89.476 O3' 46.677 -14.990 95.001 33 A P 45.077 -15.118 95.141 O3' 47.050 -16.570 98.074 34 C P 48.042 -16.345 99.324 O3' 50.497 -12.276 102.264 35 G P 49.604 -12.887 103.453 O3' 53.637 -11.217 106.416 36 G P 54.839 -12.278 106.292 O3' 58.122 -13.766 109.518 37 A P 59.193 -14.490 108.557 O3' 62.333 -17.557 111.354 38 A P 63.790 -17.981 110.830 O3' 64.799 -18.098 115.335 39 A P 63.870 -17.695 116.587 O3' 63.680 -22.674 119.306 40 G P 63.501 -24.165 118.724 O3' 61.235 -28.390 119.798 41 U P 61.836 -29.465 118.757 O3' 59.432 -33.361 116.491 42 G P 60.492 -33.837 115.372 O3' 59.532 -35.489 110.757 43 C P 60.875 -35.677 109.902 O3' 60.533 -35.349 104.744 44 C P 61.977 -35.759 104.168 O3' 64.170 -33.913 100.225 45 A P 65.491 -34.810 100.113 O3' 63.544 -39.694 98.954 46 C P 64.973 -40.438 99.009 O3' 66.845 -42.800 94.929 47 A P 68.357 -43.011 95.428 O3' 72.465 -41.379 92.767 48 G P 73.868 -41.675 93.489 O3' 77.411 -38.823 95.529 49 A P 78.234 -40.006 96.231 O3' 77.636 -39.366 101.419 50 G P 76.080 -38.968 101.537 O3' 74.314 -35.136 104.762 51 A P 72.715 -35.342 104.752 O3' 69.939 -33.054 106.841 52 A P 69.358 -31.967 107.867 O3' 70.088 -29.080 111.390 53 G P 71.107 -28.411 112.473 O3' 76.380 -29.574 112.823 54 A P 77.181 -29.147 111.487 O3' 77.180 -33.775 109.043 55 G P 78.625 -34.313 109.493 O3' 81.339 -36.697 105.501 56 A P 82.887 -36.990 105.788 O3' 85.721 -39.105 101.171 57 C P 85.073 -40.560 100.914 O3' 86.178 -41.855 96.353 58 C P 87.701 -41.471 96.011 O3' 89.348 -39.810 91.538 59 G P 90.868 -39.371 91.802 O3' 92.962 -34.880 90.933 60 C P 94.507 -34.741 91.371 O3' 96.789 -30.657 92.490 61 C P 98.319 -31.041 92.771 O3' 101.828 -29.772 97.194 62 A P 103.101 -30.309 96.396 O3' 107.872 -31.073 99.507 63 G P 107.949 -29.470 99.456 O3' 108.684 -28.352 104.507 64 C P 109.205 -29.642 105.302 O3' 108.805 -31.730 109.654 65 G P 109.624 -33.106 109.501 O3' 109.178 -37.521 111.578 66 G P 110.340 -38.363 110.840 O3' 109.956 -43.222 109.274 67 C P 111.288 -43.673 108.495 O3' 111.945 -46.800 104.835 68 C P 113.475 -46.614 104.377 O3' 115.241 -46.986 99.835 69 G P 116.809 -46.654 99.974 O3' 119.469 -45.148 95.697 70 G P 121.035 -44.986 96.027 O3' 124.984 -40.705 95.634 71 G P 126.262 -40.589 96.608 O3' 128.794 -36.839 98.190 72 G P 129.966 -37.618 98.962 O3' 132.954 -35.919 102.865 73 C P 119.419 -38.787 115.665 O3' 120.301 -33.851 112.970 74 C P 118.901 -33.442 112.279 O3' 118.899 -29.823 107.783 75 C P 117.888 -29.829 106.539 O3' 119.162 -28.312 101.930 76 C P 117.742 -28.524 101.215 O3' 116.757 -29.868 96.520 77 G P 115.169 -30.091 96.424 O3' 112.598 -33.183 93.190 78 G P 111.044 -33.433 93.540 O3' 108.390 -37.550 92.175 79 U P 106.811 -37.548 92.474 O3' 103.344 -41.181 95.370 80 G P 101.892 -40.578 95.062 O3' 98.843 -42.733 98.738 81 C P 97.799 -42.926 99.962 O3' 96.898 -43.849 104.727 82 G P 96.167 -42.617 105.464 O3' 96.495 -40.737 109.942 83 G P 95.199 -39.841 109.616 O3' 95.691 -34.567 109.889 84 G P 94.224 -34.000 109.502 O3' 93.829 -29.230 107.626 85 C P 92.226 -29.140 107.588 O3' 90.263 -26.256 104.089 86 A P 88.801 -25.996 104.694 O3' 84.714 -24.398 101.787 87 A P 84.250 -23.603 100.432 O3' 86.001 -23.685 94.937 88 G P 84.737 -24.486 94.349 O3' 84.612 -26.077 89.463 89 G P 83.168 -26.748 89.274 O3' 82.151 -30.736 86.481 90 G P 80.563 -30.517 86.440 O3' 77.296 -34.338 86.917 91 U P 75.814 -33.783 87.169 O3' 72.100 -35.579 89.504 92 G P 71.043 -34.506 88.927 O3' 67.354 -32.609 92.090 93 A P 66.661 -31.801 90.879 O3' 68.111 -26.561 91.218 94 A P 69.631 -26.701 91.720 O3' 71.370 -24.024 95.955 95 A P 72.926 -24.377 95.703 O3' 75.938 -24.650 100.263 96 C P 77.500 -24.257 100.249 O3' 77.573 -20.804 104.746 97 G P 78.735 -19.820 104.245 O3' 79.038 -18.000 98.870 98 G P 80.364 -17.833 97.970 O3' 80.327 -15.525 93.484 99 C P 81.812 -15.760 92.913 O3' 84.490 -12.430 90.335 100 G P 85.922 -13.118 90.134 O3' 90.404 -10.210 89.743 101 G P 91.808 -10.997 89.806 O3' 96.274 -10.774 93.535 102 G P 97.237 -11.969 94.015 O3' 99.991 -11.539 98.361 103 G P 100.955 -12.813 98.644 O3' 101.133 -15.835 102.813 104 U P 102.342 -16.790 102.354 O3' 102.366 -21.835 103.299 105 A P 103.689 -22.304 102.523 O3' 102.076 -24.527 98.000 106 A P 101.069 -23.349 97.579 O3' 96.473 -24.784 95.860 107 G P 95.620 -23.437 95.836 O3' 91.204 -21.925 98.766 108 A P 90.711 -20.431 98.977 O3' 86.671 -19.185 102.289 109 G P 86.728 -17.801 101.472 O3' 85.502 -17.570 106.749 110 C P 86.269 -17.489 108.157 O3' 89.776 -14.406 109.269 111 C P 89.114 -12.966 109.038 O3' 91.600 -8.561 108.091 112 C P 90.444 -7.478 107.824 O3' 90.152 -3.852 104.383 113 A P 88.690 -3.299 104.107 O3' 86.889 -0.709 100.232 114 C P 85.333 -0.593 100.610 O3' 81.410 -0.919 97.266 115 C P 79.967 -1.192 97.915 O3' 75.928 -3.394 96.444 116 G P 74.738 -3.400 97.530 O3' 71.675 -7.069 99.397 117 C P 70.876 -6.409 100.632 O3' 69.997 -8.783 105.339 118 C P 69.305 -7.670 106.278 O3' 70.225 -7.853 111.270 119 U P 69.188 -6.675 111.611 O3' 69.983 -2.366 114.421 120 G P 69.930 -2.021 115.982 O3' 70.511 2.407 118.186 121 G P 69.145 3.152 117.795 O3' 68.745 8.108 116.567 122 C P 67.374 8.555 115.855 O3' 66.743 12.658 112.668 123 C P 65.292 12.702 111.960 O3' 64.589 15.197 107.498 124 U P 63.101 15.149 106.875 O3' 61.985 15.974 102.178 125 G P 60.392 16.071 102.038 O3' 56.629 13.514 98.755 126 G P 55.433 14.206 99.586 O3' 51.107 11.353 99.956 127 C P 50.309 12.291 101.006 O3' 50.442 9.562 105.426 128 A P 51.881 8.855 105.328 O3' 51.306 3.392 106.149 129 A P 52.807 2.779 106.229 O3' 53.173 -2.206 104.176 130 C P 54.717 -2.444 104.548 O3' 58.079 -1.559 99.911 131 A P 59.680 -1.727 100.013 O3' 62.950 0.797 97.010 132 G P 64.420 0.593 97.622 O3' 68.071 4.239 96.938 133 G P 69.460 3.989 97.725 O3' 72.762 7.591 98.972 134 C P 74.060 6.961 99.689 O3' 76.764 9.814 102.958 135 C P 78.055 9.012 103.489 O3' 80.524 9.296 107.613 136 G P 81.583 8.080 107.623 O3' 82.267 4.253 111.556 137 G P 83.179 3.013 111.116 O3' 82.939 -1.158 114.096 138 G P 84.066 -1.990 113.291 O3' 83.232 -7.127 113.578 139 G P 84.808 -7.285 113.310 O3' 84.298 -12.405 111.468 140 C P 82.995 -12.349 112.428 O3' 78.556 -14.112 110.245 141 A P 78.537 -15.704 110.107 O3' 74.712 -17.399 113.154 142 C P 73.186 -17.808 113.485 O3' 70.299 -18.028 108.547 143 G P 70.426 -19.629 108.465 O3' 67.406 -18.771 104.164 144 G P 65.816 -18.638 104.345 O3' 62.078 -20.080 101.546 145 C P 60.617 -19.863 102.175 O3' 55.955 -23.233 102.287 146 A P 55.029 -21.982 102.694 O3' 50.890 -23.928 105.402 147 A P 49.705 -22.937 104.957 O3' 48.309 -25.401 102.166 148 A P 49.662 -26.284 102.168 O3' 49.314 -27.287 106.790 149 C P 48.558 -26.445 107.940 O3' 48.087 -28.573 112.819 150 C P 47.528 -27.640 114.001 O3' 50.595 -23.961 117.257 151 C P 49.726 -22.756 117.856 O3' 51.701 -18.070 119.011 152 C P 50.390 -17.161 119.255 O3' 50.180 -12.179 117.728 153 A P 48.859 -11.415 118.244 O3' 45.732 -7.977 116.288 154 C P 44.298 -7.969 117.022 O3' 39.803 -6.831 115.131 155 C P 38.699 -7.239 116.224 O3' 34.097 -8.822 115.160 51 syn 53 syn 80 syn 95 syn 109 syn 141 syn 1 155 + + c 2 154 + + c 3 153 - - c 4 152 + + c 5 19 + + c 6 18 + + c 7 17 - - c 8 16 + + c 9 15 + + c 19 129 S S t 20 34 + + c 21 32 + + c 22 31 + + c 23 30 + + c 24 29 + + c 35 151 + + c 36 150 + + c 37 148 W H t 40 149 + + c 41 148 - - c 42 145 + + c 43 144 + + c 44 143 + + c 45 93 H H t 47 51 W H t 49 90 H W c 51 92 W S t 57 89 + + c 58 88 + + c 59 85 + + c 60 84 + + c 61 83 + + c 64 82 + + c 65 81 + + c 66 79 W W c 67 78 + + c 68 77 + + c 69 76 + + c 70 75 + + c 71 74 + + c 72 73 + + c 84 106 S S t 91 95 W H t 97 115 + + c 97 139 H W c 98 109 H W c 98 114 + + c 99 113 W W c 100 112 + + c 101 111 + + c 102 110 W W c 103 108 W H t 116 140 + + c 117 138 + + c 117 142 S W c 118 137 + + c 119 136 W W c 120 135 + + c 121 134 + + c 122 133 + + c 123 132 + + c 124 131 - - c 125 130 + + c 138 141 S W c 146 149 S H c 47 95 ! ! ! 63 83 ! ! ! 80 82 ! ! ! 98 113 ! ! ! 109 113 ! ! ! 109 114 ! ! ! 114 139 ! ! ! 118 141 ! ! ! 5 129 ! ! ! 7 127 ! ! ! 25 27 ! ! ! 44 93 ! ! ! 44 94 ! ! ! 46 92 ! ! ! 84 105 ! ! ! 92 94 ! ! ! 146 150 ! ! ! 6 128 ! ! ! 20 130 ! ! ! 25 28 ! ! ! 33 34 ! ! ! 37 38 ! ! ! 44 45 ! ! ! 47 91 ! ! ! 48 50 ! ! ! 49 55 ! ! ! 50 54 ! ! ! 51 52 ! ! ! 56 57 ! ! ! 95 96 ! ! ! 96 97 ! ! ! 104 106 ! ! ! 104 107 ! ! ! 126 129 ! ! ! 1 155 4 35 151 2 40 149 2 42 145 3 5 19 5 21 32 4 57 89 2 59 85 3 64 82 2 66 79 7 97 115 6 117 138 9 SG1 10 14 SG2 20 20 SG3 25 28 SG4 33 34 SG5 37 39 SG6 45 56 SG7 62 63 SG8 80 80 SG9 86 87 SG10 90 96 SG11 103 109 SG12 116 116 SG13 126 129 SG14 139 142 SG15 146 147 1 49.005 497.096 2 48.125 483.424 3 47.245 469.752 4 46.365 456.080 5 99.861 479.756 6 93.080 491.659 7 86.298 503.563 8 79.516 515.467 9 72.734 527.371 10 69.161 541.760 11 56.836 550.000 12 42.174 547.802 13 32.806 536.310 14 33.610 521.506 15 44.165 511.095 16 50.947 499.191 17 57.729 487.287 18 64.511 475.383 19 71.292 463.479 20 64.150 459.410 21 84.856 439.672 22 91.638 427.768 23 98.419 415.864 24 105.201 403.960 25 111.316 389.485 26 126.199 384.443 27 139.852 392.222 28 143.104 407.595 29 133.770 420.237 30 126.988 432.140 31 120.207 444.044 32 113.425 455.948 33 61.011 427.681 34 52.808 428.209 35 44.605 428.737 36 43.725 415.065 37 42.845 401.393 38 41.965 387.721 39 41.085 374.049 40 40.205 360.378 41 39.324 346.706 42 36.684 305.690 43 35.804 292.019 44 34.924 278.347 45 34.396 270.144 46 33.868 261.941 47 33.340 253.738 48 32.812 245.534 49 32.284 237.331 50 31.756 229.128 51 31.228 220.925 52 30.700 212.722 53 30.172 204.519 54 29.644 196.316 55 29.116 188.113 56 28.588 179.910 57 88.774 248.781 58 90.515 235.192 59 95.737 194.425 60 97.477 180.836 61 99.218 167.246 62 100.959 153.657 63 102.699 140.068 64 104.440 126.479 65 106.181 112.890 66 109.662 85.712 67 111.403 72.123 68 113.143 58.534 69 114.884 44.945 70 116.625 31.356 71 118.365 17.767 72 120.106 4.178 73 87.492 0.000 74 85.752 13.589 75 84.011 27.178 76 82.270 40.767 77 80.530 54.356 78 78.789 67.945 79 77.048 81.534 80 75.308 95.124 81 73.567 108.713 82 71.826 122.302 83 66.604 163.069 84 64.864 176.658 85 63.123 190.247 86 61.382 203.836 87 59.641 217.425 88 57.901 231.014 89 56.160 244.603 90 55.116 252.757 91 54.071 260.910 92 53.027 269.064 93 51.982 277.217 94 50.938 285.371 95 49.894 293.524 96 48.849 301.677 97 153.223 298.228 98 153.223 284.528 99 153.223 270.828 100 153.223 257.128 101 153.223 243.428 102 153.223 229.728 103 146.372 217.543 104 147.530 203.612 105 156.299 192.726 106 169.663 188.627 107 183.028 192.726 108 191.796 203.612 109 192.954 217.543 110 186.103 229.728 111 186.103 243.428 112 186.103 257.128 113 186.103 270.828 114 186.103 284.528 115 186.103 298.228 116 194.323 298.228 117 186.103 325.628 118 186.103 339.328 119 186.103 353.028 120 186.103 366.729 121 186.103 380.429 122 186.103 394.129 123 186.103 407.829 124 186.103 421.529 125 186.103 435.229 126 187.956 450.833 127 177.520 462.582 128 161.806 462.582 129 151.370 450.833 130 153.223 435.229 131 153.223 421.529 132 153.223 407.829 133 153.223 394.129 134 153.223 380.429 135 153.223 366.729 136 153.223 353.028 137 153.223 339.328 138 153.223 325.628 139 0.000 247.647 140 0.528 255.850 141 1.056 264.053 142 1.584 272.256 143 2.112 280.459 144 2.992 294.131 145 3.872 307.802 146 4.752 321.474 147 5.632 335.146 148 6.512 348.818 149 7.392 362.490 150 10.912 417.177 151 11.792 430.849 152 13.552 458.192 153 14.432 471.864 154 15.312 485.536 155 16.192 499.208