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| Title: | | DIRECT OBSERVATION OF TWO BASE-PAIRING MODES OF A CYTOSINE-THYMINE ANALOGUE WITH GUANINE IN A DNA Z-FORM DUPLEX: SIGNIFICANCE FOR BASE ANALOGUE MUTAGENESIS | |
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| Molecular Description: | 5'-D(CpGpCpGp(C46)pG)-3' |
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| Structural Features: | Z DOUBLE HELIX |
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| Nucleic Acid Sequence: |
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| Chains | A,B: | | (DC) (DG) (DC) (DG) (C46) (DG) |
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| Primary Citation: | Moore, M.H., Van Meervelt, L., Salisbury, S.A., Lin, P.K., Brown, D.M.
Direct observation of two base-pairing modes of a cytosine-thymine analogue with guanine in a DNA Z-form duplex: significance for base analogue mutagenesis.
J.Mol.Biol.
, 251,
pp. 665 - 673, 1995.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
21
21
21
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| Cell Constants: |
| a = 18.230 | b = 30.630 | c = 43.780 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 90.00 | (degrees) |
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| Refinement: | The structure was refined using the NUCLSQ program.
The R value is
17.9
for 2798 reflections
in the resolution range 8.000 to
1.700 Ångstroms
with Fobs > 4.000 sigma(Fobs).
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