1 75 601 602 603 604 605 606 607 608 609 610 611 612 613 614 615 616 617 618 619 620 621 622 623 624 625 626 627 628 629 630 631 632 633 634 635 636 637 638 639 640 641 642 643 644 645 646 648 649 650 651 652 653 654 655 656 657 658 659 660 661 662 663 664 665 666 667 668 669 670 671 672 673 674 675 676 UCCGUGAUAG UUPAAuGGuC AGAAUGGGCG CPUGUCgCGU GCCAGAUcGG GGTPCAAUUC CCCGUCGCGG AGCCA 13 PSU 16 H2U 19 H2U 32 PSU 37 1MG 48 5MC 54 PSU LOOP1 53 59 LOOP2 14 21 LOOP3 32 38 Crystallography ? ? Angstroms 1 U P 88.434 -2.834 -63.733 O3' 89.110 -4.877 -68.475 2 C P 90.687 -5.174 -68.721 O3' 93.249 -4.391 -73.123 3 C P 94.810 -4.687 -72.791 O3' 98.888 -2.442 -74.837 4 G P 100.027 -2.826 -73.767 O3' 104.029 0.459 -72.989 5 U P 104.902 -0.427 -71.948 O3' 107.561 2.572 -68.326 6 G P 108.437 1.631 -67.364 O3' 108.231 3.285 -61.799 7 A P 109.171 2.379 -60.865 O3' 106.803 3.435 -55.482 8 U P 107.390 4.631 -54.577 O3' 109.796 3.958 -51.044 9 A P 109.266 5.271 -50.296 O3' 110.580 7.298 -44.895 10 G P 109.192 6.913 -44.138 O3' 105.063 9.808 -46.371 11 U P 105.129 9.789 -47.967 O3' 104.742 13.633 -51.481 12 U P 104.731 12.792 -52.845 O3' 107.186 13.796 -56.519 13 P P 107.721 12.887 -57.726 O3' 112.837 11.564 -59.946 14 A P 113.556 10.421 -60.781 O3' 118.793 8.667 -61.794 15 A P 118.419 7.443 -62.760 O3' 121.873 3.845 -62.424 16 u P 121.433 2.549 -63.281 O3' 122.882 -2.242 -62.323 17 G P 122.165 -3.409 -63.182 O3' 122.279 -6.193 -58.835 18 G P 123.669 -5.822 -58.095 O3' 126.341 -7.531 -53.680 19 u P 125.679 -6.814 -52.380 O3' 128.749 -2.733 -49.735 20 C P 128.535 -2.710 -48.141 O3' 124.933 1.017 -47.816 21 A P 123.763 0.340 -48.683 O3' 123.418 4.452 -50.912 22 G P 123.327 5.686 -49.901 O3' 124.957 10.230 -51.215 23 A P 124.507 11.349 -50.156 O3' 121.652 16.264 -50.809 24 A P 121.243 17.270 -49.629 O3' 117.279 20.680 -50.557 25 U P 117.248 21.354 -49.102 O3' 112.377 21.902 -46.884 26 G P 112.899 22.456 -45.467 O3' 110.166 20.751 -41.236 27 G P 111.053 21.180 -39.962 O3' 111.327 17.911 -35.759 28 G P 111.766 19.107 -34.774 O3' 114.454 17.521 -31.002 29 C P 115.088 18.793 -30.253 O3' 119.215 19.859 -28.078 30 G P 119.330 21.449 -27.877 O3' 123.740 24.971 -28.930 31 C P 123.308 26.501 -28.740 O3' 126.198 29.907 -31.338 32 P P 125.401 31.219 -30.859 O3' 124.968 34.465 -34.665 33 U P 124.644 35.651 -33.634 O3' 120.992 38.220 -36.068 34 G P 120.870 38.992 -37.469 O3' 119.177 41.076 -41.631 35 U P 118.566 40.954 -43.130 O3' 116.893 35.806 -44.456 36 C P 116.833 35.844 -46.056 O3' 112.747 33.622 -48.227 37 g P 112.388 33.672 -49.793 O3' 112.456 29.291 -47.317 38 C P 112.213 29.829 -45.825 O3' 117.407 29.891 -46.337 39 G P 118.170 28.470 -46.347 O3' 123.330 27.735 -45.967 40 U P 123.653 26.160 -45.970 O3' 127.332 24.317 -42.698 41 G P 127.370 22.758 -43.094 O3' 129.284 19.344 -39.977 42 C P 128.927 18.001 -40.759 O3' 127.766 13.540 -38.119 43 C P 127.242 12.436 -39.155 O3' 123.650 9.192 -37.277 44 A P 123.385 8.080 -38.411 O3' 118.706 5.922 -38.394 45 G P 118.547 4.883 -39.603 O3' 114.400 4.193 -42.055 46 A P 114.789 3.165 -43.215 O3' 112.099 0.991 -46.226 47 U P 112.395 -0.449 -46.865 O3' 110.506 -0.500 -52.547 48 c P 109.467 -1.266 -53.493 O3' 106.403 -3.248 -50.112 49 G P 106.467 -4.849 -49.902 O3' 103.943 -9.406 -49.125 50 G P 104.987 -10.583 -49.459 O3' 103.903 -14.674 -50.551 51 G P 105.257 -15.481 -50.861 O3' 106.656 -19.279 -54.688 52 G P 108.172 -19.624 -54.250 O3' 110.003 -21.023 -59.119 53 T P 111.502 -21.498 -58.784 O3' 114.983 -21.205 -62.442 54 P P 116.095 -22.045 -61.636 O3' 120.672 -19.990 -61.032 55 C P 121.260 -21.469 -60.780 O3' 120.950 -19.842 -55.280 56 A P 119.698 -18.911 -54.883 O3' 119.322 -14.017 -53.519 57 A P 117.809 -13.732 -53.972 O3' 115.741 -8.544 -54.232 58 U P 115.249 -8.012 -52.813 O3' 112.782 -6.047 -56.476 59 U P 113.088 -7.019 -57.722 O3' 115.232 -4.582 -62.510 60 C P 114.257 -4.774 -63.773 O3' 112.363 -8.384 -66.421 61 C P 110.777 -8.132 -66.564 O3' 106.919 -11.727 -66.977 62 C P 105.720 -10.660 -67.101 O3' 101.040 -12.567 -65.643 63 C P 100.171 -11.215 -65.640 O3' 96.565 -11.311 -62.175 64 G P 95.873 -9.886 -62.460 O3' 94.037 -7.488 -58.026 65 U P 93.278 -6.290 -58.782 O3' 93.559 -2.002 -55.600 66 C P 92.783 -0.891 -56.453 O3' 95.155 4.058 -56.624 67 G P 94.610 4.790 -57.957 O3' 97.606 8.773 -59.366 68 C P 96.762 9.431 -60.564 O3' 99.239 11.817 -64.383 69 G P 97.963 12.381 -65.177 O3' 97.624 12.744 -69.845 70 G P 96.155 13.046 -70.403 O3' 92.951 10.677 -74.554 71 A P 91.514 11.328 -74.229 O3' 87.938 7.552 -76.305 72 G P 86.539 8.203 -75.798 O3' 83.269 4.071 -75.798 73 C P 81.836 4.767 -75.648 O3' 78.719 2.865 -71.910 74 C P 77.477 3.658 -72.563 O3' 74.989 7.265 -69.737 75 A P 73.919 7.564 -70.917 O3' 70.973 11.668 -67.152 18 syn 19 syn 57 syn 59 syn 1 71 - - c 2 70 + + c 3 69 + + c 4 68 + + c 5 67 W W c 6 66 + + c 7 65 - - c 8 14 W H t 9 23 H H t 10 25 W W c 10 45 H S c 11 24 - - c 12 23 - - c 13 22 W W c 14 21 W S c 15 47 W W t 18 55 + + c 22 46 H W t 26 44 W W c 27 43 + + c 28 42 + + c 29 41 W W c 30 40 W W c 31 39 + + c 48 64 + + c 49 63 + + c 50 62 + + c 51 61 + + c 52 60 + + c 53 57 W H t 17 54 ! ! ! 31 40 ! ! ! 8 21 ! ! ! 36 38 ! ! ! 57 59 ! ! ! 18 19 ! ! ! 1 71 7 48 64 5 10 25 4 26 44 6 SG1 8 9 SG2 14 21 SG3 32 38 SG4 45 47 SG5 53 59 SG6 72 75 1 195.716 204.986 2 182.730 204.215 3 169.744 203.444 4 156.758 202.673 5 143.772 201.902 6 130.786 201.131 7 117.800 200.360 8 118.262 192.568 9 118.725 184.777 10 120.753 111.676 11 111.892 121.201 12 103.032 130.726 13 94.172 140.251 14 92.278 153.210 15 83.954 163.320 16 71.599 167.666 17 58.779 164.993 18 49.190 156.073 19 45.598 143.479 20 49.040 130.843 21 58.523 121.810 22 71.312 118.986 23 80.172 109.461 24 89.032 99.936 25 97.893 90.411 26 115.613 71.361 27 124.474 61.836 28 133.334 52.311 29 142.195 42.786 30 151.055 33.261 31 159.915 23.736 32 163.033 10.834 33 172.847 1.898 34 185.984 0.000 35 197.927 5.794 36 204.567 17.287 37 203.623 30.526 38 195.419 40.961 39 182.775 45.001 40 173.915 54.526 41 165.055 64.051 42 156.194 73.576 43 147.334 83.101 44 138.473 92.626 45 93.216 175.443 46 92.753 183.234 47 92.290 191.026 48 91.828 198.818 49 78.842 198.047 50 65.856 197.276 51 52.869 196.505 52 39.883 195.734 53 28.719 188.554 54 15.450 188.868 55 4.637 196.567 56 0.000 209.004 57 3.133 221.902 58 12.958 230.827 59 26.098 232.708 60 38.033 226.900 61 51.019 227.671 62 64.005 228.442 63 76.991 229.213 64 89.977 229.984 65 115.949 231.526 66 128.935 232.297 67 141.921 233.068 68 154.907 233.839 69 167.894 234.610 70 180.880 235.382 71 193.866 236.153 72 201.657 236.615 73 209.449 237.078 74 217.241 237.540 75 225.032 238.003 1 75 601 602 603 604 605 606 607 608 609 610 611 612 613 614 615 616 617 618 619 620 621 622 623 624 625 626 627 628 629 630 631 632 633 634 635 636 637 638 639 640 641 642 643 644 645 646 648 649 650 651 652 653 654 655 656 657 658 659 660 661 662 663 664 665 666 667 668 669 670 671 672 673 674 675 676 UCCGU GAUAGUUPAA uGGuCAGAAU GGGCGCPUGU CgCGUGCCAG AUcGGGGTPC AAUUCCCCGU CGCGGAGCCA 13 PSU 16 H2U 19 H2U 32 PSU 37 1MG 48 5MC 54 PSU LOOP4 53 59 LOOP5 14 21 LOOP6 33 37 Crystallography ? ? Angstroms 1 U P 60.098 -6.009 -38.315 O3' 58.818 -7.206 -33.434 2 C P 57.288 -7.696 -33.596 O3' 54.598 -7.191 -29.244 3 C P 53.207 -7.835 -29.734 O3' 48.869 -6.018 -27.695 4 G P 47.811 -6.800 -28.650 O3' 43.449 -3.784 -29.450 5 U P 42.626 -4.772 -30.429 O3' 39.620 -2.269 -34.009 6 G P 38.730 -3.368 -34.769 O3' 38.543 -2.690 -40.536 7 A P 37.916 -3.681 -41.662 O3' 40.163 -2.854 -46.873 8 U P 39.263 -1.865 -47.760 O3' 36.448 -2.711 -51.626 9 A P 36.954 -1.375 -52.364 O3' 35.363 0.230 -57.592 10 G P 36.842 -0.081 -58.162 O3' 40.255 3.707 -56.264 11 U P 40.295 3.668 -54.665 O3' 40.057 7.705 -50.902 12 U P 40.482 6.736 -49.682 O3' 38.001 7.741 -45.502 13 P P 37.867 6.504 -44.488 O3' 32.619 4.736 -42.503 14 A P 32.338 3.472 -41.522 O3' 28.066 1.395 -40.216 15 A P 28.211 0.060 -39.314 O3' 25.409 -4.309 -39.283 16 u P 26.086 -5.133 -38.080 O3' 25.341 -10.595 -39.096 17 G P 26.140 -11.259 -37.853 O3' 25.972 -14.115 -42.158 18 G P 24.501 -13.691 -42.685 O3' 20.761 -15.117 -46.402 19 u P 20.734 -14.015 -47.592 O3' 18.790 -9.792 -50.140 20 C P 19.887 -8.736 -50.671 O3' 24.328 -9.621 -52.469 21 A P 23.981 -8.499 -53.571 O3' 23.389 -3.867 -51.096 22 G P 22.993 -3.135 -52.477 O3' 21.378 1.638 -50.523 23 A P 21.570 2.522 -51.860 O3' 23.333 7.829 -50.858 24 A P 23.240 8.391 -52.357 O3' 26.409 12.703 -51.900 25 U P 26.526 13.282 -53.402 O3' 31.002 14.560 -55.484 26 G P 30.683 14.789 -57.035 O3' 33.627 13.142 -61.488 27 G P 32.660 13.591 -62.685 O3' 32.681 10.631 -66.894 28 G P 31.775 11.738 -67.636 O3' 29.192 9.576 -71.464 29 C P 28.407 10.837 -72.086 O3' 24.001 10.679 -73.925 30 G P 23.819 12.202 -74.362 O3' 19.327 15.424 -72.938 31 C P 19.430 17.031 -73.060 O3' 16.115 19.470 -70.169 32 P P 16.558 20.834 -70.927 O3' 16.920 24.673 -67.326 33 U P 17.224 25.882 -68.368 O3' 18.938 30.106 -64.946 34 G P 19.881 29.727 -63.679 O3' 21.945 32.250 -61.185 35 U P 22.414 31.962 -59.663 O3' 24.811 27.132 -57.832 36 C P 24.973 27.398 -56.247 O3' 29.633 25.645 -54.065 37 g P 29.501 25.782 -52.457 O3' 30.309 21.598 -55.347 38 C P 30.303 22.047 -56.888 O3' 24.981 21.170 -55.779 39 G P 24.526 19.626 -55.960 O3' 19.616 18.434 -55.824 40 U P 19.703 16.838 -55.693 O3' 16.371 14.143 -58.849 41 G P 16.631 12.673 -58.217 O3' 15.030 8.820 -61.321 42 C P 15.709 7.530 -60.634 O3' 17.257 3.551 -63.680 43 C P 17.982 2.611 -62.587 O3' 21.817 -0.271 -64.914 44 A P 22.715 -1.213 -63.968 O3' 27.727 -2.763 -63.867 45 G P 27.956 -3.580 -62.502 O3' 32.221 -3.035 -59.681 46 A P 31.958 -4.549 -59.216 O3' 35.277 -6.134 -55.266 47 U P 35.026 -7.722 -55.170 O3' 36.996 -7.331 -49.551 48 c P 38.115 -7.782 -48.484 O3' 41.075 -9.748 -51.836 49 G P 40.916 -11.343 -51.957 O3' 44.181 -15.062 -53.078 50 G P 43.416 -16.461 -52.874 O3' 45.281 -20.844 -51.159 51 G P 43.949 -21.706 -51.402 O3' 43.160 -25.114 -46.880 52 G P 41.981 -26.158 -47.137 O3' 39.279 -27.247 -42.159 53 T P 37.950 -28.083 -42.487 O3' 34.321 -27.979 -39.064 54 P P 33.412 -28.886 -40.035 O3' 28.383 -27.284 -40.289 55 C P 27.748 -28.611 -40.953 O3' 27.653 -27.196 -45.907 56 A P 28.974 -26.291 -46.070 O3' 28.978 -21.325 -47.683 57 A P 30.552 -21.061 -47.460 O3' 32.385 -15.712 -47.459 58 U P 32.523 -15.093 -48.940 O3' 35.166 -12.734 -45.186 59 U P 35.056 -14.025 -44.216 O3' 33.328 -11.404 -39.264 60 C P 34.159 -11.550 -37.890 O3' 36.104 -14.738 -35.279 61 C P 37.596 -14.161 -35.335 O3' 41.799 -17.126 -34.130 62 C P 43.171 -16.385 -34.514 O3' 47.538 -17.750 -36.390 63 C P 48.147 -16.250 -36.427 O3' 52.008 -16.313 -39.840 64 G P 52.501 -14.821 -39.487 O3' 54.015 -12.267 -43.712 65 U P 54.312 -10.799 -43.128 O3' 53.982 -6.873 -46.499 66 C P 54.484 -5.677 -45.546 O3' 51.814 -0.932 -45.908 67 G P 51.953 0.127 -44.705 O3' 48.146 3.594 -43.748 68 C P 49.165 4.440 -42.859 O3' 46.994 6.935 -38.644 69 G P 48.388 7.597 -38.226 O3' 48.416 8.671 -33.151 70 G P 49.947 9.212 -33.028 O3' 52.101 8.264 -28.657 71 A P 53.636 8.784 -28.676 O3' 57.836 5.714 -26.603 72 G P 59.192 6.405 -27.113 O3' 63.245 2.763 -27.004 73 C P 64.455 3.826 -27.067 O3' 68.122 2.438 -30.358 74 C P 69.041 3.706 -29.968 O3' 70.900 7.461 -32.911 75 A P 71.873 7.977 -31.738 O3' 74.481 12.715 -34.844 18 syn 57 syn 1 71 - - c 2 70 + + c 3 69 + + c 4 68 + + c 5 67 W W c 6 66 + + c 7 64 W W c 7 65 - - c 8 14 W H t 9 23 H H t 10 25 W W c 10 45 H S c 11 24 - - c 12 23 - - c 13 22 W W c 14 21 W S c 15 47 W W t 16 58 W W t 17 54 W S t 18 55 + + c 22 46 H W t 25 45 W W c 26 44 W W c 27 43 + + c 28 42 + + c 29 41 + + c 30 40 W W c 31 39 + + c 48 64 + + c 49 63 + + c 50 62 + + c 51 61 + + c 52 60 + + c 53 57 W H t 32 38 ! ! ! 8 21 ! ! ! 18 19 ! ! ! 25 37 ! ! ! 57 59 ! ! ! 1 71 7 48 64 5 10 25 4 26 44 7 SG