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As of 15-Nov-2017 number of released structures: 9208
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Polymer Type: All + Protein Function: All + Structural Features: All + Experimental Method: All

Results: 6214  Download results as an excel file       Gallery view

NDB ID:

5M68

PDB ID:

5M68 

Release:

2017-11-15

Title:

AT-rich DNA dodecamer with extra helical guanine-nickel coordination

Classification:

DNA

Authors:

Campos, J.L., Saperas, N., Acosta-Reyes, F.J., Pagan, M.

Citation:

AT-rich DNA with extra helical guanine-nickel coordination
To Be Published pp. - 0

Experiment:

X-RAY DIFFRACTION Resolution:2.64Å R work:0.227R free:0.246

NDB ID:

5MEY

PDB ID:

5MEY 

Release:

2017-11-15

Title:

Crystal structure of Smad4-MH1 bound to the GGCGC site.

Classification:

TRANSCRIPTION

Authors:

Martin-Malpartida, P., Batet, M., Kaczmarska, Z., Freier, R., Gomes, T., Aragon, E., Zou, Y., Xi, Q., Wang, Q., Ruiz, L., Vea, A., Marquez, J.A., Massague, J., Macias, M.J.

Citation:

Structural Basis for Genome Wide Recognition of 5-bp GC Motifs by SMAD Transcription Factors
To Be Published pp. - 0

Experiment:

X-RAY DIFFRACTION Resolution:2.05Å R work:0.222R free:0.238

NDB ID:

5MEZ

PDB ID:

5MEZ 

Release:

2017-11-15

Title:

Crystal structure of Smad4-MH1 bound to the GGCT site.

Classification:

TRANSCRIPTION

Authors:

Martin-Malpartida, P., Batet, M., Kaczmarska, Z., Freier, R., Gomes, T., Aragon, E., Zou, Y., Wang, Q., Xi, Q., Ruiz, L., Vea, A., Marquez, J.A., Massague, J., Macias, M.J.

Citation:

Structural Basis for Genome Wide Recognition of 5-bp GC Motifs by SMAD Transcription Factors
To Be Published pp. - 0

Experiment:

X-RAY DIFFRACTION Resolution:2.98Å R work:0.216R free:0.252

NDB ID:

5MF0

PDB ID:

5MF0 

Release:

2017-11-15

Title:

Crystal structure of Smad4-MH1 bound to the GGCCG site.

Classification:

TRANSCRIPTION

Authors:

Martin-Malpartida, P., Batet, M., Kaczmarska, Z., Freier, R., Gomes, T., Aragon, E., Zou, Y., Wang, Q., Xi, Q., Ruiz, L., Vea, A., Marquez, J.A., Massague, J., Macias, M.J.

Citation:

Structural Basis for Genome Wide Recognition of 5-bp GC Motifs by SMAD Transcription Factors
To Be Published pp. - 0

Experiment:

X-RAY DIFFRACTION Resolution:3.03Å R work:0.231R free:0.27

NDB ID:

5NM9

PDB ID:

5NM9 

Release:

2017-11-15

Title:

Crystal structure of the placozoa Trichoplax adhaerens Smad4-MH1 bound to the GGCGC site.

Classification:

TRANSCRIPTION

Authors:

Martin-Malpartida, P., Batet, M., Kaczmarska, Z., Freier, R., Gomes, T., Aragon, E., Zou, Y., Wang, Q., Xi, Q., Ruiz, L., Vea, A., Marquez, J.A., Massague, J., Macias, M.J.

Citation:

Structural Basis for Genome Wide Recognition of 5-bp GC Motifs by SMAD Transcription Factors
To Be Published pp. - 0

Experiment:

X-RAY DIFFRACTION Resolution:2.43Å R work:0.221R free:0.25

NDB ID:

5OD6

PDB ID:

5OD6 

Release:

2017-11-15

Title:

Crystal structure of Smad3-MH1 bound to the GGCGC site.

Classification:

TRANSCRIPTION

Authors:

Martin-Malpartida, P., Batet, M., Kaczmarska, Z., Freier, R., Gomes, T., Aragon, E., Zou, Y., Wang, Q., Xi, Q., Ruiz, L., Vea, A., Marquez, J.A., Massague, J., Macias, M.J.

Citation:

Structural Basis for Genome Wide Recognition of 5-bp GC Motifs by SMAD Transcription Factors
To Be Published pp. - 0

Experiment:

X-RAY DIFFRACTION Resolution:2.0Å R work:0.194R free:0.234

NDB ID:

5ODG

PDB ID:

5ODG 

Release:

2017-11-15

Title:

Crystal structure of Smad3-MH1 bound to the GGCT site.

Classification:

TRANSCRIPTION

Authors:

Martin-Malpartida, P., Batet, M., Kaczmarska, Z., Freier, R., Gomes, T., Aragon, E., Zou, Y., Wang, Q., Xi, Q., Ruiz, L., Vea, A., Marquez, J.A., Massague, J., Macias, M.J.

Citation:

Structural Basis for Genome Wide Recognition of 5-bp GC Motifs by SMAD Transcription Factors
To Be Published pp. - 0

Experiment:

X-RAY DIFFRACTION Resolution:2.12Å R work:0.199R free:0.241

NDB ID:

5OMX

PDB ID:

5OMX 

Release:

2017-11-15

Title:

X-ray Structure of the H2A-N38C Nucleosome Core Particle

Classification:

DNA BINDING PROTEIN

Authors:

Frouws, T.D., Barth, P.D., Richmond, T.J.

Citation:

Site-Specific Disulfide Crosslinked Nucleosomes with Enhanced Stability.
J. Mol. Biol. pp. - 2017

Experiment:

X-RAY DIFFRACTION Resolution:2.32Å R work:0.221R free:0.259

NDB ID:

6EL8

PDB ID:

6EL8 

Release:

2017-11-15

Title:

Crystal structure of the Forkhead domain of human FOXN1 in complex with DNA

Classification:

DNA BINDING PROTEIN

Authors:

Newman, J.A., Aitkenhead, H.A., Pinkas, D.M., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.

Citation:

Crystal structure of the Forkhead domain of human FOXN1 in complex with DNA
To be published pp. - 0

Experiment:

X-RAY DIFFRACTION Resolution:1.61Å R work:0.193R free:0.239

NDB ID:

6ERP

PDB ID:

6ERP 

Release:

2017-11-15

Title:

Structure of the human mitochondrial transcription initiation complex at the LSP promoter

Classification:

TRANSCRIPTION

Authors:

Hillen, H.S., Morozov, Y.I., Sarfallah, A., Temiakov, D., Cramer, P.

Citation:

Structural basis of mitochondrial transcription initiation
Cell(Cambridge,Mass.) pp. - 2017

Experiment:

X-RAY DIFFRACTION Resolution:4.502Å R work:0.27R free:0.31

NDB ID:

6ERQ

PDB ID:

6ERQ 

Release:

2017-11-15

Title:

Structure of the human mitochondrial transcription initiation complex at the HSP promoter

Classification:

TRANSCRIPTION

Authors:

Hillen, H.S., Morozov, Y.I., Sarfallah, A., Temiakov, D., Cramer, P.

Citation:

Structural basis of mitochondrial transcription initiation
Cell(Cambridge,Mass.) pp. - 2017

Experiment:

X-RAY DIFFRACTION Resolution:4.5Å R work:0.291R free:0.333

NDB ID:

5OT2

PDB ID:

5OT2 

Release:

2017-11-01

Title:

RNA polymerase II elongation complex in the presence of 3d-Napht-A

Classification:

TRANSCRIPTION

Authors:

Malvezzi, S., Farnung, L., Aloisi, C.M.N., Angelov, T., Cramer, P., Sturla, S.J.

Citation:

Mechanism of RNA polymerase II stalling by DNA alkylation.
Proc. Natl. Acad. Sci. U.S.A. pp. - 2017

Experiment:

X-RAY DIFFRACTION Resolution:3.2Å R work:0.178R free:0.221

NDB ID:

5WTI

PDB ID:

5WTI 

Release:

2017-11-01

Title:

Crystal structure of the CRISPR-associated protein in complex with crRNA and DNA

Classification:

Hydrolase/DNA/RNA

Authors:

Wu, D., Guan, X., Zhu, Y., Ren, K., Huang, Z.

Citation:

Structural basis of stringent PAM recognition by CRISPR-C2c1 in complex with sgRNA
Cell Res. 27 pp.705 - 708 2017

Experiment:

X-RAY DIFFRACTION Resolution:2.682Å R work:0.216R free:0.264

NDB ID:

5LXU

PDB ID:

5LXU 

Release:

2017-10-25

Title:

Structure of the DNA-binding domain of LUX ARRHYTHMO

Classification:

DNA BINDING PROTEIN

Authors:

Zubieta, C., Silva, C.S., Lai, X., Wigge, P., Nanao, M.H., Nayak, A.

Citation:

Structure of the DNA-binding domain of LUX ARRHYTHMO
To Be Published pp. - 0

Experiment:

X-RAY DIFFRACTION Resolution:2.14Å R work:0.194R free:0.231

NDB ID:

5ODL

PDB ID:

5ODL 

Release:

2017-10-25

Title:

Single-stranded DNA-binding protein from bacteriophage Enc34 in complex with ssDNA

Classification:

DNA BINDING PROTEIN

Authors:

Cernooka, E., Rumnieks, J., Tars, K., Kazaks, A.

Citation:

Structural basis for DNA recognition of a single-stranded DNA-binding protein from Enterobacter phage Enc34
To Be Published pp. - 0

Experiment:

X-RAY DIFFRACTION Resolution:1.56Å R work:0.14R free:0.191

NDB ID:

5VHV

PDB ID:

5VHV 

Release:

2017-10-25

Title:

Pseudomonas fluorescens alkylpurine DNA glycosylase AlkC bound to DNA containing an oxocarbenium-intermediate analog

Classification:

HYDROLASE/DNA

Authors:

Shi, R., Mullins, E.A., Shen, X.X., Lay, K.T., Yuen, P.K., David, S.S., Rokas, A., Eichman, B.F.

Citation:

Selective base excision repair of DNA damage by the non-base-flipping DNA glycosylase AlkC.
EMBO J. pp. - 2017

Experiment:

X-RAY DIFFRACTION Resolution:1.799Å R work:0.141R free:0.163

NDB ID:

5VI0

PDB ID:

5VI0 

Release:

2017-10-25

Title:

Pseudomonas fluorescens alkylpurine DNA glycosylase AlkC bound to DNA containing an abasic site analog

Classification:

HYDROLASE/DNA

Authors:

Shi, R., Mullins, E.A., Shen, X.X., Lay, K.T., Yuen, P.K., David, S.S., Rokas, A., Eichman, B.F.

Citation:

Selective base excision repair of DNA damage by the non-base-flipping DNA glycosylase AlkC.
EMBO J. pp. - 2017

Experiment:

X-RAY DIFFRACTION Resolution:2.396Å R work:0.167R free:0.224

NDB ID:

5WM1

PDB ID:

5WM1 

Release:

2017-10-25

Title:

Structure of the 10S (+)-trans-BP-dG modified Rev1 ternary complex

Classification:

TRANSFERASE/DNA

Authors:

Rechkoblit, O., Kolbanovskiy, A., Landes, H., Geacintov, N.E., Aggarwal, A.K.

Citation:

Mechanism of error-free replication across benzo[a]pyrene stereoisomers by Rev1 DNA polymerase.
Nat Commun 8 pp.965 - 965 2017

Experiment:

X-RAY DIFFRACTION Resolution:1.85Å R work:0.17R free:0.206

NDB ID:

5WM8

PDB ID:

5WM8 

Release:

2017-10-25

Title:

Structure of the 10R (+)-cis-BP-dG modified Rev1 ternary complex

Classification:

TRANSFERASE/DNA

Authors:

Rechkoblit, O., Kolbanovskiy, A., Landes, H., Geacintov, N.E., Aggarwal, A.K.

Citation:

Mechanism of error-free replication across benzo[a]pyrene stereoisomers by Rev1 DNA polymerase.
Nat Commun 8 pp.965 - 965 2017

Experiment:

X-RAY DIFFRACTION Resolution:1.92Å R work:0.176R free:0.213

NDB ID:

5WMB

PDB ID:

5WMB 

Release:

2017-10-25

Title:

Structure of the 10S (-)-cis-BP-dG modified Rev1 ternary complex (the BP residue is disordered)

Classification:

transferase/dna

Authors:

Rechkoblit, O., Kolbanovskiy, A., Landes, H., Geacintov, N.E., Aggarwal, A.K.

Citation:

Mechanism of error-free replication across benzo[a]pyrene stereoisomers by Rev1 DNA polymerase.
Nat Commun 8 pp.965 - 965 2017

Experiment:

X-RAY DIFFRACTION Resolution:2.25Å R work:0.169R free:0.217

NDB ID:

6EO6

PDB ID:

6EO6 

Release:

2017-10-25

Title:

X-ray structure of the complex between human alpha-thrombin and modified 15-mer DNA aptamer containing 5-(3-(2-(1H-indol-3-yl)acetamide-N-yl)-1-propen-1-yl)-2'-deoxyuridine residue

Classification:

Hydrolase/DNA

Authors:

Dolot, R.M., Nawrot, B., Yang, X.

Citation:

Structures of human alpha-thrombin with modified 15-mer DNA aptamers
To Be Published pp. - 0

Experiment:

X-RAY DIFFRACTION Resolution:1.69Å R work:0.145R free:0.168

NDB ID:

5OLA

PDB ID:

5OLA 

Release:

2017-10-18

Title:

Structure of mitochondrial transcription elongation complex in complex with elongation factor TEFM

Classification:

TRANSCRIPTION

Authors:

Hillen, H.S., Parshin, A.V., Agaronyan, K., Morozov, Y.I., Graber, J.J., Chernev, A., Schwinghammer, K., Urlaub, H., Anikin, M., Cramer, P., Temiakov, D.

Citation:

Mechanism of Transcription Anti-termination in Human Mitochondria.
Cell pp. - 2017

Experiment:

X-RAY DIFFRACTION Resolution:3.904Å R work:0.242R free:0.275

NDB ID:

5OQN

PDB ID:

5OQN 

Release:

2017-10-18

Title:

Crystal structure of the S. cerevisiae condensin Ycg1-Brn1 subcomplex bound to DNA (short kleisin loop)

Classification:

CELL CYCLE

Authors:

Kschonsak, M., Merkel, F., Bisht, S., Metz, J., Rybin, V., Hassler, M., Haering, C.H.

Citation:

Structural Basis for a Safety-Belt Mechanism That Anchors Condensin to Chromosomes.
Cell 171 pp.588 - 600.e24 2017

Experiment:

X-RAY DIFFRACTION Resolution:3.15Å R work:0.249R free:0.28

NDB ID:

5OQO

PDB ID:

5OQO 

Release:

2017-10-18

Title:

Crystal structure of the S. cerevisiae condensin Ycg1-Brn1 subcomplex bound to DNA (crystal form II)

Classification:

CELL CYCLE

Authors:

Kschonsak, M., Merkel, F., Bisht, S., Metz, J., Rybin, V., Hassler, M., Haering, C.H.

Citation:

Structural Basis for a Safety-Belt Mechanism That Anchors Condensin to Chromosomes.
Cell 171 pp.588 - 600.e24 2017

Experiment:

X-RAY DIFFRACTION Resolution:3.25Å R work:0.235R free:0.273

NDB ID:

5OQP

PDB ID:

5OQP 

Release:

2017-10-18

Title:

Crystal structure of the S. cerevisiae condensin Ycg1-Brn1 subcomplex bound to DNA (crystal form I)

Classification:

CELL CYCLE

Authors:

Kschonsak, M., Merkel, F., Bisht, S., Metz, J., Rybin, V., Hassler, M., Haering, C.H.

Citation:

Structural Basis for a Safety-Belt Mechanism That Anchors Condensin to Chromosomes.
Cell 171 pp.588 - 600.e24 2017

Experiment:

X-RAY DIFFRACTION Resolution:2.98Å R work:0.218R free:0.261

NDB ID:

5OV2

PDB ID:

5OV2 

Release:

2017-10-18

Title:

2'F-ANA-G modified quadruplex with a flipped tetrad

Classification:

DNA

Authors:

Dickerhoff, J., Weisz, K.

Citation:

Nonconventional C-HF Hydrogen Bonds Support a Tetrad Flip in Modified G-Quadruplexes.
J Phys Chem Lett 8 pp.5148 - 5152 2017

Experiment:

SOLUTION NMR

NDB ID:

5UAN

PDB ID:

5UAN 

Release:

2017-10-18

Title:

Crystal structure of multi-domain RAR-beta-RXR-alpha heterodimer on DNA

Classification:

TRANSCRIPTION/DNA

Authors:

Chandra, V., Wu, D., Li, S., Potluri, N., Kim, Y., Rastinejad, F.

Citation:

Quaternary architecture of multi-domain RAR-beta-RXR-alpha on DNA
Nat Commun pp. - 2017

Experiment:

X-RAY DIFFRACTION Resolution:3.508Å R work:0.221R free:0.27

NDB ID:

5W2A

PDB ID:

5W2A 

Release:

2017-10-18

Title:

Structure of human DNA polymerase kappa in complex with Lucidin-derived DNA adduct and incoming dCMPNPP

Classification:

REPLICATION

Authors:

Yockey, O., Jha, V., Ghodke, P.P., Xu, T., Xu, W., Ling, H., Pradeepkumar, P.I., Zhao, L.

Citation:

Mechanism of Error-Free DNA Replication Past Lucidin-Derived DNA Damage by Human DNA Polymerase kappa.
Chem. Res. Toxicol. pp. - 2017

Experiment:

X-RAY DIFFRACTION Resolution:2.9Å R work:0.231R free:0.269

NDB ID:

5W2C

PDB ID:

5W2C 

Release:

2017-10-18

Title:

Structure of human DNA polymerase kappa in complex with Lucidin-derived DNA adduct and incoming dAMPNPP

Classification:

REPLICATION

Authors:

Yockey, O., Jha, V., Ghodke, P.P., Xu, T., Xu, W., Ling, H., Pradeepkumar, P.I., Zhao, L.

Citation:

Mechanism of Error-Free DNA Replication Past Lucidin-Derived DNA Damage by Human DNA Polymerase kappa.
Chem. Res. Toxicol. pp. - 2017

Experiment:

X-RAY DIFFRACTION Resolution:2.5Å R work:0.211R free:0.253

NDB ID:

5W9Q

PDB ID:

5W9Q 

Release:

2017-10-18

Title:

Zinc finger region of MBD1 in complex with CpG DNA

Classification:

DNA BINDING PROTEIN/DNA

Authors:

Liu, K., Xu, C., Tempel, W., Walker, J.R., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J.

Citation:

Zinc finger region of MBD1 in complex with CpG DNA
to be published pp. - 0

Experiment:

X-RAY DIFFRACTION Resolution:1.8Å R work:0.226R free:0.253

NDB ID:

5W9S

PDB ID:

5W9S 

Release:

2017-10-18

Title:

Zinc finger of human CXXC5 in complex with CpG DNA

Classification:

DNA BINDING PROTEIN/DNA

Authors:

Liu, K., Xu, C., Tempel, W., Walker, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)

Citation:

Zinc finger of human CXXC5 in complex with CpG DNA
to be published pp. - 0

Experiment:

X-RAY DIFFRACTION Resolution:2.1Å R work:0.218R free:0.253

NDB ID:

6ASB

PDB ID:

6ASB 

Release:

2017-10-18

Title:

CXXC and PHD-type zinc finger regions of FBXL19 in complex with DNA

Classification:

DNA BINDING PROTEIN/DNA

Authors:

Liu, K., Tempel, W., Walker, J.R., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)

Citation:

CXXC and PHD-type zinc finger regions of FBXL19 in complex with DNA
to be published pp. - 0

Experiment:

X-RAY DIFFRACTION Resolution:2.85Å R work:0.212R free:0.25

NDB ID:

6ASD

PDB ID:

6ASD 

Release:

2017-10-18

Title:

Zinc finger region of human TET1 in complex with CpG DNA

Classification:

DNA BINDING PROTEIN/DNA

Authors:

Liu, K., Xu, C., Tempel, W., Walker, J.R., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)

Citation:

Zinc finger region of human TET1 in complex with CpG DNA
to be published pp. - 0

Experiment:

X-RAY DIFFRACTION Resolution:1.85Å R work:0.201R free:0.234

NDB ID:

6EO7

PDB ID:

6EO7 

Release:

2017-10-18

Title:

X-ray structure of the complex between human alpha-thrombin and modified 15-mer DNA aptamer containing 5-(3-(acetamide-N-yl)-1-propen-1-yl)-2'-deoxyuridine residue

Classification:

HYDROLASE/DNA

Authors:

Dolot, R.M., Nawrot, B., Yang, X.

Citation:

Structures of human alpha-thrombin with modified 15-mer DNA aptamers
To Be Published pp. - 0

Experiment:

X-RAY DIFFRACTION Resolution:2.24Å R work:0.16R free:0.208

NDB ID:

5OXV

PDB ID:

5OXV 

Release:

2017-10-11

Title:

Structure of the 4_601_157 tetranucleosome (C2 form)

Classification:

GENE REGULATION

Authors:

Ekundayo, B., Richmond, T.J., Schalch, T.

Citation:

Capturing Structural Heterogeneity in Chromatin Fibers.
J. Mol. Biol. 429 pp.3031 - 3042 2017

Experiment:

X-RAY DIFFRACTION Resolution:6.721Å R work:0.317R free:0.352

NDB ID:

5TVP

PDB ID:

5TVP 

Release:

2017-10-11

Title:

SUMO2 bound to Mouse Tdp2 catalytic domain with a 5'-phosphorylated DNA ternary complex

Classification:

hydrolase/dna

Authors:

Schellenberg, M.J., Lieberman, J.A., Herrero-Ruiz, A., Butler, L.R., Williams, J.G., Munoz-Cabello, A.M., Mueller, G.A., London, R.E., Cortes-Ledesma, F., Williams, R.S.

Citation:

ZATT (ZNF451)-mediated resolution of topoisomerase 2 DNA-protein cross-links.
Science 357 pp.1412 - 1416 2017

Experiment:

X-RAY DIFFRACTION Resolution:2.399Å R work:0.19R free:0.233

NDB ID:

5UC6

PDB ID:

5UC6 

Release:

2017-10-11

Title:

Structural insights into IL-1 alpha recognition by a naphthyl-modified aptamer that mimics IL-1RI Domain III

Classification:

IMMUNE SYSTEM/DNA

Authors:

Ren, X., Gelinas, A.D., von Carlowitz, I., Janjic, N., Pyle, A.M.

Citation:

Structural basis for IL-1 alpha recognition by a modified DNA aptamer that specifically inhibits IL-1 alpha signaling.
Nat Commun 8 pp.810 - 810 2017

Experiment:

X-RAY DIFFRACTION Resolution:2.1Å R work:0.177R free:0.219

NDB ID:

5XF3

PDB ID:

5XF3 

Release:

2017-10-11

Title:

Nucleosome core particle with an adduct of a binuclear RAPTA (Ru-arene-phosphaadamantane) compound having a 1,2-diphenylethylenediamine linker (R,R-configuration)

Classification:

STRUCTURAL PROTEIN/DNA

Authors:

Davey, G.E., Adhireksan, Z., Ma, Z., Riedel, T., Sharma, D., Padavattan, S., Rhodes, D., Ludwig, A., Sandin, S., Murray, B.S., Dyson, P., Davey, C.A.

Citation:

Nucleosome Acidic Patch-Targeting Binuclear Ruthenium Compounds Induce Aberrant Chromatin Condensation
To Be Published pp. - 0

Experiment:

X-RAY DIFFRACTION Resolution:2.6Å R work:0.234R free:0.27

NDB ID:

5XF4

PDB ID:

5XF4 

Release:

2017-10-11

Title:

Nucleosome core particle with an adduct of a binuclear RAPTA (Ru-arene-phosphaadamantane) compound having a 1,2-diphenylethylenediamine linker (S,S-configuration)

Classification:

STRUCTURAL PROTEIN/DNA

Authors:

Davey, G.E., Adhireksan, Z., Ma, Z., Riedel, T., Sharma, D., Padavattan, S., Rhodes, D., Ludwig, A., Sandin, S., Murray, B.S., Dyson, P., Davey, C.A.

Citation:

Nucleosome Acidic Patch-Targeting Binuclear Ruthenium Compounds Induce Aberrant Chromatin Condensation
To Be Published pp. - 0

Experiment:

X-RAY DIFFRACTION Resolution:2.87Å R work:0.226R free:0.265

NDB ID:

5XF5

PDB ID:

5XF5 

Release:

2017-10-11

Title:

Nucleosome core particle with an adduct of a binuclear RAPTA (Ru-arene-phosphaadamantane) compound having a 1,2-diphenylethylenediamine linker (R,S-configuration)

Classification:

STRUCTURAL PROTEIN/DNA

Authors:

Davey, G.E., Adhireksan, Z., Ma, Z., Riedel, T., Sharma, D., Padavattan, S., Rhodes, D., Ludwig, A., Sandin, S., Murray, B.S., Dyson, P., Davey, C.A.

Citation:

Nucleosome Acidic Patch-Targeting Binuclear Ruthenium Compounds Induce Aberrant Chromatin Condensation
To Be Published pp. - 0

Experiment:

X-RAY DIFFRACTION Resolution:2.82Å R work:0.227R free:0.263

NDB ID:

5XF6

PDB ID:

5XF6 

Release:

2017-10-11

Title:

Nucleosome core particle with an adduct of a binuclear RAPTA (Ru-arene-phosphaadamantane) compound having an ethylenediamine linker

Classification:

STRUCTURAL PROTEIN/DNA

Authors:

Davey, G.E., Adhireksan, Z., Ma, Z., Riedel, T., Sharma, D., Padavattan, S., Rhodes, D., Ludwig, A., Sandin, S., Murray, B.S., Dyson, P., Davey, C.A.

Citation:

Nucleosome Acidic Patch-Targeting Binuclear Ruthenium Compounds Induce Aberrant Chromatin Condensation
To Be Published pp. - 0

Experiment:

X-RAY DIFFRACTION Resolution:2.63Å R work:0.208R free:0.254

NDB ID:

5XZE

PDB ID:

5XZE 

Release:

2017-10-11

Title:

Mouse cGAS bound to the inhibitor RU332

Classification:

IMMUNE SYSTEM/INHIBITOR

Authors:

Vincent, J., Adura, C., Gao, P., Luz, A., Lama, L., Asano, Y., Okamoto, R., Imaeda, T., Aida, J., Rothamel, K., Gogakos, T., Steinberg, J., Reasoner, S., Aso, K., Tuschl, T., Patel, D.J., Glickman, J.F., Ascano, M.

Citation:

Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice.
Nat Commun 8 pp.750 - 750 2017

Experiment:

X-RAY DIFFRACTION Resolution:2.177Å R work:0.242R free:0.28

NDB ID:

5XZG

PDB ID:

5XZG 

Release:

2017-10-11

Title:

Mouse cGAS bound to the inhibitor RU521

Classification:

IMMUNE SYSTEM/INHIBITOR

Authors:

Vincent, J., Adura, C., Gao, P., Luz, A., Lama, L., Asano, Y., Okamoto, R., Imaeda, T., Aida, J., Rothamel, K., Gogakos, T., Steinberg, J., Reasoner, S., Aso, K., Tuschl, T., Patel, D.J., Glickman, J.F., Ascano, M.

Citation:

Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice.
Nat Commun 8 pp.750 - 750 2017

Experiment:

X-RAY DIFFRACTION Resolution:1.828Å R work:0.193R free:0.231

NDB ID:

5XOU

PDB ID:

5XOU 

Release:

2017-10-04

Title:

Crystal structure of T. thermophilus Argonaute protein complexed with a bulge 7T8 on the guide strand

Classification:

DNA BINDING PROTEIN

Authors:

Sheng, G., Gogakos, T., Wang, J., Zhao, H., Serganov, A., Juranek, S., Tuschl, T., Patel, D.J., Wang, Y.

Citation:

Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes
Nucleic Acids Res. 45 pp.9149 - 9163 2017

Experiment:

X-RAY DIFFRACTION Resolution:2.63Å R work:0.234R free:0.275

NDB ID:

5XOW

PDB ID:

5XOW 

Release:

2017-10-04

Title:

Crystal structure of T. thermophilus Argonaute protein complexed with a bulge 6'A7' on the target strand

Classification:

DNA BINDING PROTEIN

Authors:

Sheng, G., Gogakos, T., Wang, J., Zhao, H., Serganov, A., Juranek, S., Tuschl, T., Patel, D.J., Wang, Y.

Citation:

Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes
Nucleic Acids Res. 45 pp.9149 - 9163 2017

Experiment:

X-RAY DIFFRACTION Resolution:2.902Å R work:0.214R free:0.256

NDB ID:

5XQ2

PDB ID:

5XQ2 

Release:

2017-10-04

Title:

Crystal structure of T. thermophilus Argonaute protein complexed with a bulge 5A6 on the guide strand

Classification:

DNA BINDING PROTEIN

Authors:

Sheng, G., Gogakos, T., Wang, J., Zhao, H., Serganov, A., Juranek, S., Tuschl, T., Patel, D.J., Wang, Y.

Citation:

Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes
Nucleic Acids Res. 45 pp.9149 - 9163 2017

Experiment:

X-RAY DIFFRACTION Resolution:3.33Å R work:0.252R free:0.293

NDB ID:

5XVN

PDB ID:

5XVN 

Release:

2017-10-04

Title:

E. far Cas1-Cas2/prespacer binary complex

Classification:

IMMUNE SYSTEM

Authors:

Xiao, Y., Ng, S., Hyun Nam, K., Ke, A.

Citation:

How type II CRISPR-Cas establish immunity through Cas1-Cas2-mediated spacer integration.
Nature 550 pp.137 - 141 2017

Experiment:

X-RAY DIFFRACTION Resolution:3.25Å R work:0.205R free:0.249

NDB ID:

5XVO

PDB ID:

5XVO 

Release:

2017-10-04

Title:

E. fae Cas1-Cas2/prespacer/target ternary complex revealing DNA sampling and half-integration states

Classification:

IMMUNE SYSTEM

Authors:

Xiao, Y., Ng, S., Hyun Nam, K., Ke, A.

Citation:

How type II CRISPR-Cas establish immunity through Cas1-Cas2-mediated spacer integration.
Nature 550 pp.137 - 141 2017

Experiment:

X-RAY DIFFRACTION Resolution:3.1Å R work:0.193R free:0.233

NDB ID:

5XVP

PDB ID:

5XVP 

Release:

2017-10-04

Title:

E. fae Cas1-Cas2/prespacer/target ternary complex revealing the fully integrated states

Classification:

IMMUNE SYSTEM

Authors:

Xiao, Y., Ng, S., Hyun Nam, K., Ke, A.

Citation:

How type II CRISPR-Cas establish immunity through Cas1-Cas2-mediated spacer integration.
Nature 550 pp.137 - 141 2017

Experiment:

X-RAY DIFFRACTION Resolution:3.0Å R work:0.193R free:0.232

NDB ID:

5U01

PDB ID:

5U01 

Release:

2017-09-27

Title:

Cooperative DNA binding by two RelA dimers

Classification:

TRANSCRIPTION/DNA

Authors:

Mulero, M.C., Huang, D.B., Nguyen, H.T., Wang, V., Li, Y., Biswas, T., Ghosh, G.

Citation:

DNA-binding affinity and transcriptional activity of the RelA homodimer of nuclear factor kappa B are not correlated.
J. Biol. Chem. pp. - 2017

Experiment:

X-RAY DIFFRACTION Resolution:2.5Å R work:0.221R free:0.273