A Portal for Three-dimensional Structural Information about Nucleic Acids
As of 10-Aug-2017 number of released structures: 9059
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Polymer Type: All + RNA Type: All + Protein Function: All + Experimental Method: All + RNA Sequence Type: All RNA Sequence

Results: 3351  Download results as an excel file       Gallery view

NDB ID:

5NRG

PDB ID:

5NRG 

Release:

2017-08-09

Title:

The crystal structure of the large ribosomal subunit of Staphylococcus aureus in complex with RB02

Classification:

RIBOSOME

Authors:

Matzov, D., Eyal, Z., Ben Hamou, R.I., Halfon, Y., Krupkin, M., Zimmerman, E., Rozenberg, H., Bashan, A., Fridman, M., Yonath, A.

Citation:

Structural insights of lincosamides targeting the ribosome of Staphylococcus aureus
Nucleic Acids Res. pp. - 2017

Experiment:

X-RAY DIFFRACTION Resolution:3.442Å R work:0.218R free:0.261

NDB ID:

5TGG

PDB ID:

5TGG 

Release:

2017-08-09

Title:

Solution structure of parallel stranded adenosine duplex

Classification:

RNA,DNA

Authors:

Copp, W., Denisov, A., Xie, J., Noronha, A., Liczner, C., Safaee, N., Wilds, C., Gehring, K.

Citation:

Influence of Nucleotide Modifications at the C2' Position on the Hoogsteen Base-Paired Parallel-Stranded Duplex of Poly(A) RNA
Nucleic Acids Res. pp. - 2017

Experiment:

SOLUTION NMR

NDB ID:

5WJR

PDB ID:

5WJR 

Release:

2017-08-09

Title:

2-Se-T2/4-DNA and native RNA hybrid in complex with RNase H catalytic domain D132N mutant

Classification:

HYDROLASE

Authors:

Fang, Z., Huang, Z.

Citation:

RNase H catalytic domain D132N mutant in complex with native DNA/RNA at 1.70 angstroms
To Be Published pp. - 0

Experiment:

X-RAY DIFFRACTION Resolution:1.7Å R work:0.188R free:0.233

NDB ID:

5XUS

PDB ID:

5XUS 

Release:

2017-08-09

Title:

Crystal structure of Lachnospiraceae bacterium ND2006 Cpf1 in complex with crRNA and target DNA (TTTA PAM)

Classification:

HYDROLASE/RNA/DNA

Authors:

Yamano, T., Zetsche, B., Ishitani, R., Zhang, F., Nishimasu, H., Nureki, O.

Citation:

Structural basis for the canonical and non-canonical PAM recognition by CRISPR-Cpf1
To Be Published pp. - 0

Experiment:

X-RAY DIFFRACTION Resolution:2.5Å R work:0.178R free:0.227

NDB ID:

5XUT

PDB ID:

5XUT 

Release:

2017-08-09

Title:

Crystal structure of Lachnospiraceae bacterium ND2006 Cpf1 in complex with crRNA and target DNA (TCTA PAM)

Classification:

HYDROLASE/RNA/DNA

Authors:

Yamano, T., Zetsche, B., Ishitani, R., Zhang, F., Nishimasu, H., Nureki, O.

Citation:

Structural basis for the canonical and non-canonical PAM recognition by CRISPR-Cpf1
To Be Published pp. - 0

Experiment:

X-RAY DIFFRACTION Resolution:2.4Å R work:0.192R free:0.237

NDB ID:

5XUU

PDB ID:

5XUU 

Release:

2017-08-09

Title:

Crystal structure of Lachnospiraceae bacterium ND2006 Cpf1 in complex with crRNA and target DNA (TCCA PAM)

Classification:

HYDROLASE/RNA/DNA

Authors:

Yamano, T., Zetsche, B., Ishitani, R., Zhang, F., Nishimasu, H., Nureki, O.

Citation:

Structural basis for the canonical and non-canonical PAM recognition by CRISPR-Cpf1
To Be Published pp. - 0

Experiment:

X-RAY DIFFRACTION Resolution:2.5Å R work:0.192R free:0.244

NDB ID:

5XUZ

PDB ID:

5XUZ 

Release:

2017-08-09

Title:

Crystal structure of Lachnospiraceae bacterium ND2006 Cpf1 in complex with crRNA and target DNA (CCCA PAM)

Classification:

HYDROLASE/RNA/DNA

Authors:

Yamano, T., Zetsche, B., Ishitani, R., Zhang, F., Nishimasu, H., Nureki, O.

Citation:

Structural basis for the canonical and non-canonical PAM recognition by CRISPR-Cpf1
To Be Published pp. - 0

Experiment:

X-RAY DIFFRACTION Resolution:2.4Å R work:0.177R free:0.229

NDB ID:

5O1Y

PDB ID:

5O1Y 

Release:

2017-08-02

Title:

Stucture of Nrd1 RNA binding domain in complex with RNA (GUAA)

Classification:

TRANSCRIPTION

Authors:

Franco-Echevarria, E., Gonzalez-Polo, N., Zorrilla, S., Martinez-Lumbreras, S., Santiveri, C.M., Campos-Olivas, R., Sanchez, M., Calvo, O., Gonzalez, B., Perez-Canadillas, J.M.

Citation:

The structure of transcription termination factor Nrd1 reveals an original mode for GUAA recognition
Nucleic Acids Res. pp. - 2017

Experiment:

X-RAY DIFFRACTION Resolution:2.45Å R work:0.196R free:0.217

NDB ID:

5O1Z

PDB ID:

5O1Z 

Release:

2017-08-02

Title:

Stucture of Nrd1 RNA binding domain in complex with RNA (CGUAAA)

Classification:

TRANSCRIPTION

Authors:

Franco-Echevarria, E., Gonzalez-Polo, N., Zorrilla, S., Martinez-Lumbreras, S., Santiveri, C.M., Campos-Olivas, R., Sanchez, M., Calvo, O., Gonzalez, B., Perez-Canadillas, J.M.

Citation:

The structure of transcription termination factor Nrd1 reveals an original mode for GUAA recognition
Nucleic Acids Res. pp. - 2017

Experiment:

X-RAY DIFFRACTION Resolution:3.4Å R work:0.181R free:0.215

NDB ID:

5O20

PDB ID:

5O20 

Release:

2017-08-02

Title:

Stucture of Nrd1 RNA binding domain in complex with RNA (UUAGUAAUCC)

Classification:

TRANSCRIPTION

Authors:

Franco-Echevarria, E., Gonzalez-Polo, N., Zorrilla, S., Martinez-Lumbreras, S., Santiveri, C.M., Campos-Olivas, R., Sanchez, M., Calvo, O., Gonzalez, B., Perez-Canadillas, J.M.

Citation:

The structure of transcription termination factor Nrd1 reveals an original mode for GUAA recognition
Nucleic Acids Res. pp. - 2017

Experiment:

X-RAY DIFFRACTION Resolution:3.53Å R work:0.225R free:0.268

NDB ID:

5U9B

PDB ID:

5U9B 

Release:

2017-08-02

Title:

Solution structure of the zinc fingers 1 and 2 of MBNL1 in complex with human cardiac troponin T pre-mRNA

Classification:

RNA BINDING PROTEIN/RNA

Authors:

Park, S., Phukan, P.D., Zeeb, M., Martinez-Yamout, M.A., Dyson, H.J., Wright, P.E.

Citation:

Structural basis for interaction of the tandem zinc finger domains of human muscleblind with cognate RNA from human cardiac troponin T.
Biochemistry pp. - 2017

Experiment:

SOLUTION NMR

NDB ID:

5VZJ

PDB ID:

5VZJ 

Release:

2017-08-02

Title:

STRUCTURE OF A TWELVE COMPONENT MPP6-NUCLEAR RNA EXOSOME COMPLEX BOUND TO RNA

Classification:

HYDROLASE/RNA

Authors:

Wasmuth, E.V., Zinder, J.C., Zattas, D., Das, M., Lima, C.D.

Citation:

Structure and reconstitution of yeast Mpp6-nuclear exosome complexes reveals that Mpp6 stimulates RNA decay and recruits the Mtr4 helicase.
Elife 6 pp. - 2017

Experiment:

X-RAY DIFFRACTION Resolution:3.3Å R work:0.216R free:0.265

NDB ID:

5NQI

PDB ID:

5NQI 

Release:

2017-07-26

Title:

E.coli 16S rRNA Sarcin-Ricin Loop containing a 5-hydroxymethylcytosine modification

Classification:

RNA

Authors:

Riml, C., Lusser, A., Ennifar, E., Micura, R.

Citation:

Synthesis, Thermodynamic Properties, and Crystal Structure of RNA Oligonucleotides Containing 5-Hydroxymethylcytosine.
J. Org. Chem. pp. - 2017

Experiment:

X-RAY DIFFRACTION Resolution:0.851Å R work:0.145R free:0.17

NDB ID:

5TBW

PDB ID:

5TBW 

Release:

2017-07-26

Title:

Crystal structure of chlorolissoclimide bound to the yeast 80S ribosome

Classification:

RIBOSOME

Authors:

Konst, Z.A., Szklarski, A.R., Pellegrino, S., Michalak, S.E., Meyer, M., Zanette, C., Cencic, R., Nam, S., Voora, V.K., Horne, D.A., Pelletier, J., Mobley, D.L., Yusupova, G., Yusupov, M., Vanderwal, C.D.

Citation:

Synthesis facilitates an understanding of the structural basis for translation inhibition by the lissoclimides
Nat.Chem. pp. - 2017

Experiment:

X-RAY DIFFRACTION Resolution:3.0Å R work:0.193R free:0.226

NDB ID:

5V2R

PDB ID:

5V2R 

Release:

2017-07-26

Title:

Structure of a GA Rich 8x8 Nucleotide RNA Internal Loop

Classification:

RNA

Authors:

Kauffmann, A.D., Kennedy, S.D., Zhao, J., Turner, D.H.

Citation:

Nuclear Magnetic Resonance Structure of an 8 8 Nucleotide RNA Internal Loop Flanked on Each Side by Three Watson-Crick Pairs and Comparison to Three-Dimensional Predictions.
Biochemistry 56 pp.3733 - 3744 2017

Experiment:

SOLUTION NMR

NDB ID:

5VI5

PDB ID:

5VI5 

Release:

2017-07-26

Title:

Structure of Mycobacterium smegmatis transcription initiation complex with a full transcription bubble

Classification:

TRANSCRIPTION

Authors:

Hubin, E.A., Lilic, M., Darst, S.A., Campbell, E.A.

Citation:

Structural insights into the mycobacteria transcription initiation complex from analysis of X-ray crystal structures.
Nat Commun 8 pp.16072 - 16072 2017

Experiment:

X-RAY DIFFRACTION Resolution:3.196Å R work:0.253R free:0.279

NDB ID:

5W6V

PDB ID:

5W6V 

Release:

2017-07-26

Title:

The Structure of human Argonaute-1 in complex with the hook motif of human GW182

Classification:

GENE REGULATION/RNA

Authors:

Elkayam, E., Faehnle, C.R., Morales, M., Jingchuan, S., Li, H., Joshua-Tor, L.

Citation:

Multivalent Recruitment of Human Argonaute by GW182
Mol.Cell pp. - 2017

Experiment:

X-RAY DIFFRACTION Resolution:2.828Å R work:0.2R free:0.244

NDB ID:

5KH8

PDB ID:

5KH8 

Release:

2017-07-19

Title:

Solution structures of the apo state fluoride riboswitch

Classification:

RNA

Authors:

Zhao, B., Guffy, S.L., Williams, B., Zhang, Q.

Citation:

An excited state underlies gene regulation of a transcriptional riboswitch.
Nat. Chem. Biol. pp. - 2017

Experiment:

SOLUTION NMR

NDB ID:

5VYC

PDB ID:

5VYC 

Release:

2017-07-19

Title:

Crystal structure of the human 40S ribosomal subunit in complex with DENR-MCT-1.

Classification:

RIBOSOME

Authors:

Lomakin, I.B., Stolboushkina, E.A., Vaidya, A.T., Zhao, C., Garber, M.B., Dmitriev, S.E., Steitz, T.A.

Citation:

Crystal Structure of the Human Ribosome in Complex with DENR-MCT-1.
Cell Rep 20 pp.521 - 528 2017

Experiment:

X-RAY DIFFRACTION Resolution:6.0Å R work:0.322R free:0.32

NDB ID:

5W5H

PDB ID:

5W5H 

Release:

2017-07-19

Title:

Human IFIT1 dimer with m7Gppp-AAAA

Classification:

RNA binding protein/RNA

Authors:

Abbas, Y.M., Martinez-Montero, S., Cencic, R., Pelletier, J., Damha, M.J., Pawelek, P.D., Nagar, B.

Citation:

Structural insights into IFIT1 dimerization and conformational changes associated with mRNA binding
To Be Published pp. - 0

Experiment:

X-RAY DIFFRACTION Resolution:2.79Å R work:0.218R free:0.24

NDB ID:

5V16

PDB ID:

5V16 

Release:

2017-07-12

Title:

HnRNP A1 Alters the Conformation of a Conserved Enterovirus IRES Domain to Stimulate Viral Translation

Classification:

RNA

Authors:

Tolbert, M., Morgan, C.E., Pollum, M., Crespo-Hernandez, C.E., Li, M.L., Brewer, G., Tolbert, B.S.

Citation:

HnRNP A1 Alters the Structure of a Conserved Enterovirus IRES Domain to Stimulate Viral Translation.
J. Mol. Biol. pp. - 2017

Experiment:

SOLUTION NMR

NDB ID:

5V17

PDB ID:

5V17 

Release:

2017-07-12

Title:

HnRNP A1 Alters the Conformation of a Conserved Enterovirus IRES Domain to Stimulate Viral Translation

Classification:

RNA

Authors:

Tolbert, M., Morgan, C.E., Pollum, M., Crespo-Hernandez, C.E., Li, M.L., Brewer, G., Tolbert, B.S.

Citation:

HnRNP A1 Alters the Structure of a Conserved Enterovirus IRES Domain to Stimulate Viral Translation.
J. Mol. Biol. pp. - 2017

Experiment:

SOLUTION NMR

NDB ID:

5MPG

PDB ID:

5MPG 

Release:

2017-07-05

Title:

Solution NMR structure of hnRNP A1 RRM1 in complex with 5'-UUAGGUC-3' RNA

Classification:

SPLICING

Authors:

Beusch, I., Barraud, P., Moursy, A., Clery, A., Allain, F.H.

Citation:

Tandem hnRNP A1 RNA recognition motifs act in concert to repress the splicing of survival motor neuron exon 7.
Elife 6 pp. - 2017

Experiment:

SOLUTION NMR

NDB ID:

5MPL

PDB ID:

5MPL 

Release:

2017-07-05

Title:

hnRNP A1 RRM2 in complex with 5'-UCAGUU-3' RNA

Classification:

SPLICING

Authors:

Beusch, I., Barraud, P., Moursy, A., Clery, A., Allain, F.H.

Citation:

Tandem hnRNP A1 RNA recognition motifs act in concert to repress the splicing of survival motor neuron exon 7.
Elife 6 pp. - 2017

Experiment:

SOLUTION NMR

NDB ID:

5O3J

PDB ID:

5O3J 

Release:

2017-07-05

Title:

Crystal structure of TIA-1 RRM2 in complex with RNA

Classification:

RNA BINDING PROTEIN

Authors:

Sonntag, M., Jagtap, P.K.A., Simon, B., Appavou, M.S., Geerlof, A., Stehle, R., Gabel, F., Hennig, J., Sattler, M.

Citation:

Segmental, Domain-Selective Perdeuteration and Small-Angle Neutron Scattering for Structural Analysis of Multi-Domain Proteins.
Angew. Chem. Int. Ed. Engl. 56 pp.9322 - 9325 2017

Experiment:

X-RAY DIFFRACTION Resolution:2.97Å R work:0.25R free:0.311

NDB ID:

5T3K

PDB ID:

5T3K 

Release:

2017-07-05

Title:

Fluorescence detection of RNA-ligand binding and crystal structure determination of ribosomal decoding site RNA using a heavy atom containing fluorescent ribonucleoside

Classification:

RNA

Authors:

Nuthanakanti, A., Boerneke, M.A., Hermann, T., Srivatsan, S.G.

Citation:

Structure of the Ribosomal RNA Decoding Site Containing a Selenium-Modified Responsive Fluorescent Ribonucleoside Probe.
Angew. Chem. Int. Ed. Engl. 56 pp.2640 - 2644 2017

Experiment:

X-RAY DIFFRACTION Resolution:2.142Å R work:0.197R free:0.246

NDB ID:

5TWS

PDB ID:

5TWS 

Release:

2017-07-05

Title:

Post-catalytic complex of human Polymerase Mu (H329A) with newly incorporated UTP

Classification:

TRANSFERASE/DNA

Authors:

Moon, A.F., Pryor, J.M., Ramsden, D.A., Kunkel, T.A., Bebenek, K., Pedersen, L.C.

Citation:

Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme Polymerase Mu
Nucleic Acids Res. pp. - 2017

Experiment:

X-RAY DIFFRACTION Resolution:1.85Å R work:0.166R free:0.2

NDB ID:

5UED

PDB ID:

5UED 

Release:

2017-07-05

Title:

RNA primer-template complex with guanosine dinucleotide ligand G(5')pp(5')G

Classification:

RNA

Authors:

Zhang, W., Tam, C.P., Walton, T., Fahrenbach, A.C., Birrane, G., Szostak, J.W.

Citation:

Insight into the mechanism of nonenzymatic RNA primer extension from the structure of an RNA-GpppG complex.
Proc. Natl. Acad. Sci. U.S.A. 114 pp.7659 - 7664 2017

Experiment:

X-RAY DIFFRACTION Resolution:1.5Å R work:0.21R free:0.232

NDB ID:

5UEE

PDB ID:

5UEE 

Release:

2017-07-05

Title:

RNA primer-template complex with guanosine dinucleotide ligand G(5')ppp(5')G

Classification:

RNA

Authors:

Zhang, W., Tam, C.P., Walton, T., Fahrenbach, A.C., Birrane, G., Szostak, J.W.

Citation:

Insight into the mechanism of nonenzymatic RNA primer extension from the structure of an RNA-GpppG complex.
Proc. Natl. Acad. Sci. U.S.A. 114 pp.7659 - 7664 2017

Experiment:

X-RAY DIFFRACTION Resolution:1.9Å R work:0.231R free:0.274

NDB ID:

5UEF

PDB ID:

5UEF 

Release:

2017-07-05

Title:

RNA primer-template complex with guanosine dinucleotide p(5')G(3')p(5')G ligand

Classification:

RNA

Authors:

Zhang, W., Tam, C.P., Walton, T., Fahrenbach, A.C., Birrane, G., Szostak, J.W.

Citation:

Insight into the mechanism of nonenzymatic RNA primer extension from the structure of an RNA-GpppG complex.
Proc. Natl. Acad. Sci. U.S.A. 114 pp.7659 - 7664 2017

Experiment:

X-RAY DIFFRACTION Resolution:2.1Å R work:0.239R free:0.303

NDB ID:

5UEG

PDB ID:

5UEG 

Release:

2017-07-05

Title:

RNA primer-template complex with guanosine dinucleotide G(5')pppp(5')G ligand

Classification:

RNA

Authors:

Zhang, W., Tam, C.P., Walton, T., Fahrenbach, A.C., Birrane, G., Szostak, J.W.

Citation:

Insight into the mechanism of nonenzymatic RNA primer extension from the structure of an RNA-GpppG complex.
Proc. Natl. Acad. Sci. U.S.A. 114 pp.7659 - 7664 2017

Experiment:

X-RAY DIFFRACTION Resolution:2.6Å R work:0.207R free:0.301

NDB ID:

5V3I

PDB ID:

5V3I 

Release:

2017-07-05

Title:

Crystal structure of the VS ribozyme - wild-type C634

Classification:

RNA

Authors:

DasGupta, S., Suslov, N.B., Piccirilli, J.A.

Citation:

Structural Basis for Substrate Helix Remodeling and Cleavage Loop Activation in the Varkud Satellite Ribozyme.
J. Am. Chem. Soc. 139 pp.9591 - 9597 2017

Experiment:

X-RAY DIFFRACTION Resolution:3.293Å R work:0.216R free:0.246

NDB ID:

5VZ8

PDB ID:

5VZ8 

Release:

2017-07-05

Title:

Post-catalytic complex of human Polymerase Mu (G433A) mutant with incoming UTP

Classification:

TRANSFERASE/DNA

Authors:

Moon, A.F., Pryor, J.M., Ramsden, D.A., Kunkel, T.A., Bebenek, K., Pedersen, L.C.

Citation:

Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme Polymerase Mu
Nucleic Acids Res. pp. - 2017

Experiment:

X-RAY DIFFRACTION Resolution:1.601Å R work:0.171R free:0.193

NDB ID:

5VZB

PDB ID:

5VZB 

Release:

2017-07-05

Title:

Post-catalytic complex of human Polymerase Mu (G433S) mutant with incoming UTP

Classification:

TRANSFERASE/DNA

Authors:

Moon, A.F., Pryor, J.M., Ramsden, D.A., Kunkel, T.A., Bebenek, K., Pedersen, L.C.

Citation:

Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme Polymerase Mu
Nucleic Acids Res. pp. - 2017

Experiment:

X-RAY DIFFRACTION Resolution:1.5Å R work:0.17R free:0.187

NDB ID:

5VZE

PDB ID:

5VZE 

Release:

2017-07-05

Title:

Post-catalytic complex of human Polymerase Mu (W434A) mutant with incoming UTP

Classification:

TRANSFERASE/DNA

Authors:

Moon, A.F., Pryor, J.M., Ramsden, D.A., Kunkel, T.A., Bebenek, K., Pedersen, L.C.

Citation:

Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme Polymerase Mu
Nucleic Acids Res. pp. - 2017

Experiment:

X-RAY DIFFRACTION Resolution:1.506Å R work:0.177R free:0.2

NDB ID:

5VZH

PDB ID:

5VZH 

Release:

2017-07-05

Title:

Post-catalytic complex of human Polymerase Mu (W434H) mutant with incoming UTP

Classification:

TRANSFERASE/DNA

Authors:

Moon, A.F., Pryor, J.M., Ramsden, D.A., Kunkel, T.A., Bebenek, K., Pedersen, L.C.

Citation:

Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme Polymerase Mu
Nucleic Acids Res. pp. - 2017

Experiment:

X-RAY DIFFRACTION Resolution:1.95Å R work:0.178R free:0.21

NDB ID:

5WQ1

PDB ID:

5WQ1 

Release:

2017-07-05

Title:

Solution Structure of the first stem-loop of Escherichia coli DsrA RNA

Classification:

RNA

Authors:

Wu, P., Liu, X., Yang, L., Sun, Y., Gong, Q., Wu, J., Shi, Y.

Citation:

Conformational plasticity of DsrA sRNA for adaption multiple target regulation
NUCLEIC ACIDS RES. pp. - 2017

Experiment:

SOLUTION NMR

NDB ID:

5X21

PDB ID:

5X21 

Release:

2017-07-05

Title:

Crystal structure of Thermus thermophilus transcription initiation complex with GpA and pseudouridimycin (PUM)

Classification:

TRANSFERASE/DNA

Authors:

Maffioli, S.I., Zhang, Y., Degen, D., Carzaniga, T., Del Gatto, G., Serina, S., Monciardini, P., Mazzetti, C., Guglierame, P., Candiani, G., Chiriac, A.I., Facchetti, G., Kaltofen, P., Sahl, H.G., Deho, G., Donadio, S., Ebright, R.H.

Citation:

Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase.
Cell 169 pp.1240 - 1248.e23 2017

Experiment:

X-RAY DIFFRACTION Resolution:3.323Å R work:0.231R free:0.28

NDB ID:

5X22

PDB ID:

5X22 

Release:

2017-07-05

Title:

Crystal structure of Thermus thermophilus transcription initiation complex with GpA and CMPcPP

Classification:

TRANSFERASE/DNA

Authors:

Maffioli, S.I., Zhang, Y., Degen, D., Carzaniga, T., Del Gatto, G., Serina, S., Monciardini, P., Mazzetti, C., Guglierame, P., Candiani, G., Chiriac, A.I., Facchetti, G., Kaltofen, P., Sahl, H.G., Deho, G., Donadio, S., Ebright, R.H.

Citation:

Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase.
Cell 169 pp.1240 - 1248.e23 2017

Experiment:

X-RAY DIFFRACTION Resolution:3.35Å R work:0.207R free:0.25

NDB ID:

5MEI

PDB ID:

5MEI 

Release:

2017-06-28

Title:

Crystal structure of Agelastatin A bound to the 80S ribosome

Classification:

RIBOSOME

Authors:

McClary, B., Zinshteyn, B., Meyer, M., Jouanneau, M., Pellegrino, S., Yusupova, G., Schuller, A., Reyes, J.C.P., Lu, J., Guo, Z., Ayinde, S., Luo, C., Dang, Y., Romo, D., Yusupov, M., Green, R., Liu, J.O.

Citation:

Inhibition of Eukaryotic Translation by the Antitumor Natural Product Agelastatin A.
Cell Chem Biol 24 pp.605 - 613.e5 2017

Experiment:

X-RAY DIFFRACTION Resolution:3.5Å R work:0.195R free:0.238

NDB ID:

5VH7

PDB ID:

5VH7 

Release:

2017-06-28

Title:

Structure and dynamics of RNA repeat expansions that cause Huntington's Disease and myotonic dystrophy type 1

Classification:

RNA

Authors:

Chen, J.L., VanEtten, D.M., Fountain, M.A., Yildirim, I., Disney, M.D.

Citation:

Structure and Dynamics of RNA Repeat Expansions That Cause Huntington's Disease and Myotonic Dystrophy Type 1.
Biochemistry 56 pp.3463 - 3474 2017

Experiment:

SOLUTION NMR

NDB ID:

5VH8

PDB ID:

5VH8 

Release:

2017-06-28

Title:

Structure and dynamics of RNA repeat expansions that cause Huntington's Disease and myotonic dystrophy type 1

Classification:

RNA

Authors:

Chen, J.L., VanEtten, D.M., Fountain, M.A., Yildirim, I., Disney, M.D.

Citation:

Structure and Dynamics of RNA Repeat Expansions That Cause Huntington's Disease and Myotonic Dystrophy Type 1.
Biochemistry 56 pp.3463 - 3474 2017

Experiment:

SOLUTION NMR

NDB ID:

5VJ9

PDB ID:

5VJ9 

Release:

2017-06-28

Title:

Guanidine-II riboswitch P2 hairpin dimer from Pseudomonas aeruginosa

Classification:

RNA

Authors:

Reiss, C.W., Strobel, S.A.

Citation:

Structural basis for ligand binding to the guanidine-II riboswitch.
RNA pp. - 2017

Experiment:

X-RAY DIFFRACTION Resolution:1.57Å R work:0.192R free:0.234

NDB ID:

5VJB

PDB ID:

5VJB 

Release:

2017-06-28

Title:

Guanidine-II riboswitch P2 hairpin dimer with 5-bromoU substitution from Pseudomonas aeruginosa

Classification:

RNA

Authors:

Reiss, C.W., Strobel, S.A.

Citation:

Structural basis for ligand binding to the guanidine-II riboswitch.
RNA pp. - 2017

Experiment:

X-RAY DIFFRACTION Resolution:2.1Å R work:0.215R free:0.238

NDB ID:

5VP2

PDB ID:

5VP2 

Release:

2017-06-28

Title:

Crystal structure of the Thermus thermophilus 70S ribosome in complex with madumycin II and bound to mRNA and A-, P- and E-site tRNAs at 2.8A resolution

Classification:

RIBOSOME

Authors:

Osterman, I.A., Khabibullina, N.F., Komarova, E.S., Kasatsky, P., Kartsev, V.G., Bogdanov, A.A., Dontsova, O.A., Konevega, A.L., Sergiev, P.V., Polikanov, Y.S.

Citation:

Madumycin II inhibits peptide bond formation by forcing the peptidyl transferase center into an inactive state.
Nucleic Acids Res. pp. - 2017

Experiment:

X-RAY DIFFRACTION Resolution:2.8Å R work:0.229R free:0.278

NDB ID:

5VW1

PDB ID:

5VW1 

Release:

2017-06-28

Title:

Crystal structure of SpyCas9-sgRNA-AcrIIA4 ternary complex

Classification:

HYDROLASE

Authors:

Yang, H., Patel, D.J.

Citation:

Inhibition Mechanism of an Anti-CRISPR Suppressor AcrIIA4 Targeting SpyCas9.
Mol. Cell 67 pp.117 - 127.e5 2017

Experiment:

X-RAY DIFFRACTION Resolution:2.598Å R work:0.178R free:0.226

NDB ID:

5W0M

PDB ID:

5W0M 

Release:

2017-06-28

Title:

Structure of human TUT7 catalytic module (CM) in complex with U5 RNA

Classification:

TRANSFERASE/RNA

Authors:

Faehnle, C.R., Walleshauser, J., Joshua-Tor, L.

Citation:

Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis.
Nat. Struct. Mol. Biol. pp. - 2017

Experiment:

X-RAY DIFFRACTION Resolution:2.298Å R work:0.188R free:0.228

NDB ID:

5W0O

PDB ID:

5W0O 

Release:

2017-06-28

Title:

Structure of human TUT7 catalytic module (CM) in complex with dsRNA

Classification:

TRANSFERASE/RNA

Authors:

Faehnle, C.R., Walleshauser, J., Joshua-Tor, L.

Citation:

Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis.
Nat. Struct. Mol. Biol. pp. - 2017

Experiment:

X-RAY DIFFRACTION Resolution:2.488Å R work:0.205R free:0.254

NDB ID:

5W5I

PDB ID:

5W5I 

Release:

2017-06-28

Title:

Human IFIT1 dimer with PPP-AAAA

Classification:

RNA binding protein/RNA

Authors:

Abbas, Y.M., Martinez-Montero, S., Cencic, R., Pelletier, J., Damha, M.J., Pawelek, P.D., Nagar, B.

Citation:

Structural insights into IFIT1 dimerization and conformational changes associated with mRNA binding
To Be Published pp. - 0

Experiment:

X-RAY DIFFRACTION Resolution:2.65Å R work:0.218R free:0.241

NDB ID:

5W7N

PDB ID:

5W7N 

Release:

2017-06-28

Title:

2-Se-T2/4-DNA and native RNA hybrid in complex with RNase H catalytic domain D132N mutant

Classification:

HYDROLASE/DNA/RNA

Authors:

Fang, Z., Yang, F., Huang, Z.

Citation:

2-Se-T2/4-modified-DNA and native RNA hybrid in complex with RNase H catalytic domain D132N mutant
To Be Published pp. - 0

Experiment:

X-RAY DIFFRACTION Resolution:1.8Å R work:0.192R free:0.232