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NDB ID: 1CX5    PDB ID: 1CX5 


Title:

ANTISENSE DNA/RNA HYBRID CONTAINING MODIFIED BACKBONE

Molecular Description:

5'-D(*CP*GP*CP*GP*TP*T*(MMT)P*TP*GP*CP*GP*C)-3'
5'-R(*GP*CP*GP*CP*AP*AP*AP*AP*CP*GP*CP*G)-3'

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Yang, X., Han, X., Cross, C., Bare, S., Sanghvi, Y., Gao, X.
NMR structure of an antisense DNA.RNA hybrid duplex containing a 3'-CH(2)N(CH(3))-O-5' or an MMI backbone linker. 
Biochemistry, 38, pp. 12586 - 12596, 1999.

Experimental Information:

SOLUTION NMR

Space Group:

P 1

Cell Constants:

a = 1.0   b = 1.0   c = 1.0 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the program. The R value is for reflections in the resolution range to Ångstroms

Number of Models:

Number of Models: 1 Structures

Sample Details:

1-2 mM hybrid duplex in 0.1 M NaCl, 10 mM sodium phosphate and 0.1 mM sodium EDTA. 99.96% D2O or 90% H2O/10% D2O