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NDB ID: 1EI2    PDB ID: 1EI2 


Title:

STRUCTURAL BASIS FOR RECOGNITION OF THE RNA MAJOR GROOVE IN THE TAU EXON 10 SPLICING REGULATORY ELEMENT BY AMINOGLYCOSIDE ANTIBIOTICS

Molecular Description:

STRUCTURAL BASIS FOR RECOGNITION OF THE RNA MAJOR GROOVE IN THE TAU EXON 10 SPLICING REGULATORY ELEMENT BY AMINOGLYCOSIDE ANTIBIOTICS

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Varani, L., Spillantini, M.G., Goedert, M., Varani, G.
Structural basis for recognition of the RNA major groove in the tau exon 10 splicing regulatory element by aminoglycoside antibiotics. 
Nucleic Acids Res., 28, pp. 710 - 719, 2000.

Experimental Information:

SOLUTION NMR

Space Group:

P 1

Cell Constants:

a = 1.0   b = 1.0   c = 1.0 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the program. The R value is for reflections in the resolution range to Ångstroms

Number of Models:

Number of Models: 17 Structures

Sample Details:

1mM tau exon 10 SRE RNA U-13C,15N; 10mM phosphate buffer, pH 6; 1mM neomycin unlabelled 90% H2O, 10% D2O