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NDB ID: PD0168    PDB ID: 1F4R 


Title:

CRYSTAL STRUCTURE OF THE HUMAN AAG DNA REPAIR GLYCOSYLASE COMPLEXED WITH 1,N6-ETHENOADENINE-DNA

Molecular Description:

3-METHYL-ADENINE DNA GLYCOSYLASE (E.C.3.2.2.20)/DNA COMPLEX

Deposited:

2000-06-08

Released:

2000-12-11

Structural Keywords:

B DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Lau, A.Y., Wyatt, M.D., Glassner, B.J., Samson, L.D., Ellenberger, T.
Molecular basis for discriminating between normal and damaged bases by the human alkyladenine glycosylase, AAG. 
Proc.Natl.Acad.Sci.USA, 97, pp. 13573 - 13578, 2000.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 42.1   b = 57.3   c = 125.5 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.0 for 12526 reflections in the resolution range 500.0 to 2.4 Ångstroms with Fobs >  4.0 sigma(Fobs) and with I >  2.0 sigma(I)