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NDB ID: DR0012    PDB ID: 1O9M 


Title:

THE COMPLEX OF A NOVEL ANTIBIOTIC WITH THE AMINOACYL SITE OF THE BACTERIAL RIBOSOME REVEALED BY X-RAY CRYSTALLOGRAPHY.

Molecular Description:

5'-R(*C*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3'
PAROMOMYCIN (RING 2)
4-AMINO-2-HYDROXYBUTANOIC ACID

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Russell, R., Murray, J.B., Lentzen, G., Haddad, J., Mobashery, S.
The Complex of a Designer Antibiotic with a Model Aminoacyl Site of the 30S Ribosomal Subunit Revealed by X-Ray Crystallography 
J.Am.Chem.Soc., 125, pp. 3410 - , 2003.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 32.8   b = 46.55   c = 88.81 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.2507 for 5247 reflections in the resolution range 30.0 to 2.4 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)