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NDB ID: ZDFB43    PDB ID: 223D 


Title:

DIRECT OBSERVATION OF TWO BASE-PAIRING MODES OF A CYTOSINE-THYMINE ANALOGUE WITH GUANINE IN A DNA Z-FORM DUPLEX: SIGNIFICANCE FOR BASE ANALOGUE MUTAGENESIS

Molecular Description:

5'-D(*CP*GP*CP*GP*(C46)P*G)-3'

Deposited:

1995-08-01

Released:

1995-12-09

Structural Keywords:

Z DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Moore, M.H., Van Meervelt, L., Salisbury, S.A., Lin, P.K., Brown, D.M.
Direct observation of two base-pairing modes of a cytosine-thymine analogue with guanine in a DNA Z-form duplex: significance for base analogue mutagenesis. 
J.Mol.Biol., 251, pp. 665 - 673, 1995.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 18.23   b = 30.63   c = 43.78 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the NUCLSQ program. The R value is 0.179 for 2798 reflections in the resolution range 8.0 to 1.7 Ångstroms with Fobs >  4.0 sigma(Fobs) and with I >  0.0 sigma(I)