NDB ID: RR0134 PDB ID: 2F4V 
Title:
30S RIBOSOME + DESIGNER ANTIBIOTIC
Molecular Description:
30S ribosomal subunit
Deposited:
2005-11-24
Released:
2006-07-04
Structural Keywords:
SINGLE STRAND, LOOPS, HAIRPIN LOOP
Nucleic Acid Sequence:
Click to show/hide 2 nucleic acid sequences
Chain A
UUGUUGGAGAGUUUGAUCCUGGCUCAGGGUGAACGCUGGCGGCGUGCCUAAGACAUGCAAGUCGUGCGGGCCGCGGGGUU UUACUCCGU
GGUCAGCGGCGGACGGGUGAGUAACGCGUGGGUGACCUACCCGGAAGAGGGGGACAACCCGGGGAAACUCG GGCUAAUCCCCCAUGUGG
ACCCGCCCCUUGGGGUGUGUCCAAAGGGCUUUGCCCGCUUCCGGAUGGGCCCGCGUCCCAUC AGCUAGUUGGUGGGGUAAUGGCCCACC
AAGGCGACGACGGGUAGCCGGUCUGAGAGGAUGGCCGGCCACAGGGGCACUGA GACACGGGCCCCACUCCUACGGGAGGCAGCAGUUAG
GAAUCUUCCGCAAUGGGCGCAAGCCUGACGGAGCGACGCCGCUU GGAGGAAGAAGCCCUUCGGGGUGUAAACUCCUGAACCCGGGACGA
AACCCCCGACGAGGGGACUGACGGUACCGGGGUAA UAGCGCCGGCCAACUCCGUGCCAGCAGCCGCGGUAAUACGGAGGGCGCGAGCGU
UACCCGGAUUCACUGGGCGUAAAGGG CGUGUAGGCGGCCUGGGGCGUCCCAUGUGAAAGACCACGGCUCAACCGUGGGGGAGCGUGGGA
UACGCUCAGGCUAGACG GUGGGAGAGGGUGGUGGAAUUCCCGGAGUAGCGGUGAAAUGCGCAGAUACCGGGAGGAACGCCGAUGGCGAA
GGCAGCCA CCUGGUCCACCCGUGACGCUGAGGCGCGAAAGCGUGGGGAGCAAACCGGAUUAGAUACCCGGGUAGUCCACGCCCUAAAC
GAUGCGCGCUAGGUCUCUGGGUCUCCUGGGGGCCGAAGCUAACGCGUUAAGCGCGCCGCCUGGGGAGUACGGCCGCAAGG CUGAAACUC
AAAGGAAUUGACGGGGGCCCGCACAAGCGGUGGAGCAUGUGGUUUAAUUCGAAGCAACGCGAAGAACCUUA CCAGGCCUUGACAUGCUA
GGGAACCCGGGUGAAAGCCUGGGGUGCCCCGCGAGGGGAGCCCUAGCACAGGUGCUGCAUGG CCGUCGUCAGCUCGUGCCGUGAGGUGU
UGGGUUAAGUCCCGCAACGAGCGCAACCCCCGCCGUUAGUUGCCAGCGGUUCG GCCGGGCACUCUAACGGGACUGCCCGCGAAAGCGGG
AGGAAGGAGGGGACGACGUCUGGUCAGCAUGGCCCUUACGGCCU GGGCGACACACGUGCUACAAUGCCCACUACAAAGCGAUGCCACCC
GGCAACGGGGAGCUAAUCGCAAAAAGGUGGGCCCA GUUCGGAUUGGGGUCUGCAACCCGACCCCAUGAAGCCGGAAUCGCUAGUAAUCG
CGGAUCAGCCAUGCCGCGGUGAAUAC GUUCCCGGGCCUUGUACACACCGCCCGUCACGCCAUGGGAGCGGGCUCUACCCGAAGUCGCCG
GGAGCCUACGGGCAGGC GCCGAGGGUAGGGCCCGUGACUGGGGCGAAGUCGUAACAAGGUAGCUGUACCGGAAGGUGCGGCUGGAUCA
Chain Z
UUCU
Protein Sequence:
Click to show/hide 19 protein sequences
Chain J
MPKIRIKLRGFDHKTLDASAQKIVEAARRSGAQVSGPIPLPTRVRRFTVIRGPFKHKDSREHFELRTHNRLVDIINPNRK TIEQLMTLD
LPTGVEIEIKTVGGGR
Chain I
MEQYYGTGRRKEAVARVFLRPGNGKVTVNGQDFNEYFQGLVRAVAALEPLRAVDALGRFDAYITVRGGGKSGQIDAIKLG IARALVQYN
PDYRAKLKPLGFLTRDARVVERKKYGKHKARRAPQYSKR
Chain L
MPTINQLVRKGREKVRKKSKVPALKGAPFRRGVCTVVRTVTPKKPNSALRKVAKVRLTSGYEVTAYIPGEGHNLQEHSVV LIRGGRVKD
LPGVRYHIVRGVYDAAGVKDRKKSRSKYGTKKPKEAAKTAAKK
Chain K
MAKKPSKKKVKRQVASGRAYIHASYNNTIVTITDPDGNPITWSSGGVIGYKGSRKGTPYAAQLAALDAAKKAMAYGMQSV DVIVRGTGA
GREQAIRALQASGLQVKSIVDDTPVPHNGCRPKKKFRKAS
Chain N
MARKALIEKAKRTPKFKVRAYTRCVRCGRARSVYRFFGLCRICLRELAHKGQLPGVRKASW
Chain M
MARIAGVEIPRNKRVDVALTYIYGIGKARAKEALEKTGINPATRVKDLTEAEVVRLREYVENTWKLEGELRAEVAANIKR LMDIGCYRG
LRHRRGLPVRGQRTRTNARTRKGPRKTVAGKKKAPRK
Chain P
MVKIRLARFGSKHNPHYRIVVTDARRKRDGKYIEKIGYYDPRKTTPDWLKVDVERARYWLSVGAQPTDTARRLLRQAGVF RQEAREGA
Chain O
MPITKEEKQKVIQEFARFPGDTGSTEVQVALLTLRINRLSEHLKVHKKDHHSHRGLLMMVGQRRRLLRYLQREDPERYRA LIEKLGIRG
Chain R
MSTKNAKPKKEAQRRPSRKAKVKATLGEFDLRDYRNVEVLKRFLSETGKILPRRRTGLSGKEQRILAKTIKRARILGLLP FTEKLVRK
Chain Q
MPKKVLTGVVVSDKMQKTVTVLVERQFPHPLYGKVIKRSKKYLAHDPEEKYKLGDVVEIIESRPISKRKRFRVLRLVESG RMDLVEKYL
IRRQNYQSLSKRGGKA
Chain B
MPVEITVKELLEAGVHFGHERKRWNPKFARYIYAERNGIHIIDLQKTMEELERTFRFIEDLAMRGGTILFVGTKKQAQDI VRMEAERAG
MPYVNQRWLGGMLTNFKTISQRVHRLEELEALFASPEIEERPKKEQVRLKHELERLQKYLSGFRLLKRLPD AIFVVDPTKEAIAVREAR
KLFIPVIALADTDSDPDLVDYIIPGNDDAIRSIQLILSRAVDLIIQARGGVVEPSPSYALVQ EAEATETPEGESEVEA
Chain D
MGRYIGPVCRLCRREGVKLYLKGERCYSPKCAMERRPYPPGQHGQKRARRPSDYAVRLREKQKLRRIYGISERQFRNLFE EASKKKGVT
GSVFLGLLESRLDNVVYRLGFAVSRRQARQLVRHGHITVNGRRVDLPSYRVRPGDEIAVAEKSRNLELIRQ NLEAMKGRKVGPWLSLDV
EGMKGKFLRLPDREDLALPVQENLVIEFYSR
Chain C
MGNKIHPIGFRLGITRDWESRWYAGKKQYRHLLLEDQRIRGLLEKELYSAGLARVDIERAADNVAVTVHVAKPGVVIGRG GERIRVLRE
ELAKLTGKNVALNVQEVQNPNLSAPLVAQRVAEQIERRFAVRRAIKQAVQRVMESGAKGAKVIVSGRIGGA EQARTEWAAQGRVPLHTL
RANIDYGFALARTTYGVLGVKAYIFLGEVIGGQKPKARPELPKAEERPRRRRPAVRVKKEE
Chain F
MRRYEVNIVLNPNLDQSQLALEKEIIQRALENYGARVEKVEELGLRRLAYPIAKDPQGYFLWYQVEMPEDRVNDLARELR IRDNVRRVM
VVKSQEPFLANA
Chain E
MPETDFEEKMILIRRTARMQAGGRRFRFGALVVVGDRQGRVGLGFGKAPEVPLAVQKAGYYARRNMVEVPLQNGTIPHEI EVEFGASKI
VLKPAAPGTGVIAGAVPRAILELAGVTDILTKELGSRNPINIAYATMEALRQLRTKADVERLRKGEAHAQA QG
Chain H
MLTDPIADMLTRIRNATRVYKESTDVPASRFKEEILRILAREGFIKGYERVDVDGKPYLRVYLKYGPRRQGPDPRPEQVI HHIRRISKP
GRRVYVGVKEIPRVRRGLGIAILSTSKGVLTDREARKLGVGGELICEVW
Chain S
MPRSLKKGVFVDDHLLEKVLELNAKGEKRLIKTWSRRSTIVPEMVGHTIAVYNGKQHVPVYITENMVGHKLGEFAPTRTY RGHGKEAKA
TKKK
Chain G
MARRRRAEVRQLQPDLVYGDVLVTAFINKIMRDGKKNLAARIFYDACKIIQEKTGQEPLKVFKQAVENVKPRMEVRSRRV GGANYQVPM
EVSPRRQQSLALRWLVQAANQRPERRAAVRIAHELMDAAEGKGGAVKKKEDVERMAEANRAYAHYRW
Chain T
MAQKKPKRNLSALKRHRQSLKRRLRNKAKKSAIKTLSKKAVQLAQEGKAEEALKIMRKAESLIDKAAKGSTLHKNAAARR KSRLMRKVR
QLLEAAGAPLIGGGLSA
Primary Citation:
Murray, J.B., Meroueh, S.O., Russell, R.J., Lentzen, G., Haddad, J., Mobashery, S.
Interactions of designer antibiotics and the bacterial ribosome aminoacyl-tRNA site 
Chem.Biol., 13, pp. 129 - 138, 2006.
Experimental Information:
X-RAY DIFFRACTION
Space Group:
P 41 21 2
Cell Constants:
a = 403.323 b = 403.323 c = 176.685 (Ångstroms)
α = 90.0 β = 90.0 γ = 90.0 (degrees)
Refinement:
The structure was refined using the REFMAC program.
The R value is 0.26179 for 131434 reflections in
the resolution range 30.0 to 3.8 Ångstroms
with Fobs > 0.0 sigma(Fobs) and with I > 0.0 sigma(I)