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NDB ID: 2K7E    PDB ID: 2K7E 


Title:

NMR STRUCTURE OF THE HUMAN TRNALYS3 BOUND TO THE HIV GENOME LOOP I

Molecular Description:

5'-R(*GP*CP*GP*GP*UP*GP*UP*AP*AP*AP*AP*G)-3'

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Bilbille, Y., Vendeix, F.A., Guenther, R., Malkiewicz, A., Ariza, X., Vilarrasa, J., Agris, P.F.
The structure of the human tRNALys3 anticodon bound to the HIV genome is stabilized by modified nucleosides and adjacent mismatch base pairs. 
Nucleic Acids Res., 37, pp. 3342 - 3353, 2009.

Experimental Information:

SOLUTION NMR

Cell Constants:

a =   b =   c = (Ångstroms)

α =   β =   γ = (degrees)

Refinement:

The structure was refined using the program. The R value is for reflections in the resolution range to Ångstroms

Number of Models:

Number of Models: 10 Structures

Sample Details:

0.3 mM RNA (5'-R(*GP*CP*GP*GP*UP*GP*UP*AP*AP*AP*AP*G)-3'), 0.3 mM T-RNA (5'-R(*CP*UP*(SUR)P*UP*UP*AP*AP*(PSU)P*CP*UP*GP*C)-3'), 10 mM sodium phosphate, 100 mM sodium chloride, 90% H2O/10% D2O 90% H2O/10% D2O