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NDB ID: 2KQG    PDB ID: 2KQG 


Title:

A G-RICH SEQUENCE WITHIN THE C-KIT ONCOGENE PROMOTER FORMS A PARALLEL G-QUADRUPLEX HAVING ASYMMETRIC G-TETRAD DYNAMICS

Molecular Description:

5'-D(*CP*GP*GP*GP*CP*GP*GP*GP*CP*AP*CP*GP*AP*GP*GP*GP*AP*GP*GP*GP*T)-3'

Deposited:

2009-11-05

Released:

2009-11-24

Structural Keywords:

QUADRUPLE HELIX, TETRAPLEX, LOOPS

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Hsu, S.-T.D., Varnai, P., Bugaut, A., Reszka, A.P., Neidle, S., Balasubramanian, S.
A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics 
J.Am.Chem.Soc., 131, pp. 13399 - 13409, 2009.

Experimental Information:

SOLUTION NMR

Number of Models:

Number of Models: 10 Structures

Sample Details:

200 micro-M DNA; 10mM potassium phosphate; 93% H2O/7% D2O 93% H2O/7% D2O