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NDB ID: 2KTZ    PDB ID: 2KTZ 


Title:

INHIBITOR INDUCED STRUCTURAL CHANGE IN THE HCV IRES DOMAIN IIA RNA

Molecular Description:

HCV IRES Domain IIa RNA

Structural Keywords:

SINGLE STRAND, HAIRPIN LOOP

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Paulsen, R.B., Seth, P.P., Swayze, E.E., Griffey, R.H., Skalicky, J.J., Cheatham, T.E., Davis, D.R.
Inhibitor-induced structural change in the HCV IRES domain IIa RNA. 
Proc.Natl.Acad.Sci.USA, 107, pp. 7263 - 7268, 2010.

Experimental Information:

SOLUTION NMR

Cell Constants:

a =   b =   c = (Ångstroms)

α =   β =   γ = (degrees)

Refinement:

The structure was refined using the program. The R value is for reflections in the resolution range to Ångstroms

Number of Models:

Number of Models: 10 Structures

Sample Details:

400 uM RNA (38-MER)-1, 150 mM sodium chloride-2, 150 mM potassium chloride-3, 10 mM sodium phosphate-4, 2 mM spermine-5, 2.8 mM ISH-6, 100% D2O 100% D2O