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NDB ID: 2KWG    PDB ID: 2KWG 


Title:

SOLUTION STRUCTURE OF A FULLY MODIFIED 2'-F/2'-OME SIRNA CONSTRUCT

Molecular Description:

5'-R(*(GF2)P*(OMG)P*(GF2)P*(OMU)P*(AF2)P*(A2M)P*(AF2)P*(OMU)P*(AF2)P*(OMC)P*(AF2)P*(OMU)P*(UFT)P*(OMC)P*(UFT)P*(OMU)P*(CFZ)P*(A2M)P*(UFT)P*(OMU)P*(UFT))-3'/5'-R(P*(A2M)P*(UFT)P*(OMG)P*(AF2)P*(A2M)P*(GF2)P*(A2M)P*(AF2)P*(OMU)P*(GF2)P*(OMU)P*(AF2)P*(OMU)P*(UFT)P*(OMU)P*(AF2)P*(OMC)P*(CFZ)P*(OMC)P*(UFT)P*(OMU))-3'

Deposited:

2010-04-09

Released:

2010-07-21

Structural Keywords:

A DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Podbevsek, P., Allerson, C.R., Bhat, B., Plavec, J.
Solution-state structure of a fully alternately 2'-F/2'-OMe modified 42-nt dimeric siRNA construct. 
Nucleic Acids Res., 38, pp. 7298 - 7307, 2010.

Experimental Information:

SOLUTION NMR

Space Group:

P 1

Number of Models:

Number of Models: 10 Structures

Sample Details:

2 mM RNA-1, 2 mM RNA-2, 100% D2O 100% D2O