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NDB ID: 2L7V    PDB ID: 2L7V 


Title:

QUINDOLINE/G-QUADRUPLEX COMPLEX

Molecular Description:

5'-D(*TP*GP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*A)-3'

Deposited:

2010-12-23

Released:

2011-11-09

Structural Keywords:

QUADRUPLE HELIX, G-QUADRUPLEX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Dai, J., Carver, M., Hurley, L.H., Yang, D.
Solution Structure of a 2:1 Quindoline-c-MYC G-Quadruplex: Insights into G-Quadruplex-Interactive Small Molecule Drug Design. 
J.Am.Chem.Soc., 133, pp. 17673 - 17680, 2011.

Experimental Information:

SOLUTION NMR

Number of Models:

Number of Models: 10 Structures

Sample Details:

1 mM DNA (5'-D(*TP*GP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*A)-3'), 2 mM quindoline, 10 mM potassium phosphate, 0.1 mM DSS, 90% H2O/10% D2O 90% H2O/10% D2O