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NDB ID: 2L94    PDB ID: 2L94 


Title:

STRUCTURE OF THE HIV-1 FRAMESHIFT SITE RNA BOUND TO A SMALL MOLECULE INHIBITOR OF VIRAL REPLICATION

Molecular Description:

45-MER

Structural Keywords:

SINGLE STRAND, FLIPPED-OUT BASES, BASE TRIPLET

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Marcheschi, R.J., Tonelli, M., Kumar, A., Butcher, S.E.
Structure of the HIV-1 Frameshift Site RNA Bound to a Small Molecule Inhibitor of Viral Replication. 
Acs Chem.Biol., 6, pp. 857 - 864, 2011.

Experimental Information:

SOLUTION NMR

Cell Constants:

a =   b =   c = (Ångstroms)

α =   β =   γ = (degrees)

Refinement:

The structure was refined using the program. The R value is for reflections in the resolution range to Ångstroms

Number of Models:

Number of Models: 10 Structures

Sample Details:

0.75 mM RNA (45-MER), 0.75 mM DB213, 20 uM DSS, 20 mM potassium chloride, 10 mM [U-2H] TRIS, 90% H2O/10% D2O 90% H2O/10% D2O