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NDB ID: 2LAR    PDB ID: 2LAR 


Title:

DNA / RNA HYBRID CONTAINING A CENTRAL STEREO SPECIFIC RP BORANO PHOSPHATE LINKAGE

Molecular Description:

DNA/RNA

Structural Keywords:

A DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Johnson, C.N., Spring, A.M., Sergueev, D., Shaw, B.R., Germann, M.W.
Structural basis of the RNase H1 activity on stereo regular borano phosphonate DNA/RNA hybrids. 
Biochemistry, 50, pp. 3903 - 3912, 2011.

Experimental Information:

SOLUTION NMR

Cell Constants:

a =   b =   c = (Ångstroms)

α =   β =   γ = (degrees)

Refinement:

The structure was refined using the program. The R value is for reflections in the resolution range to Ångstroms

Number of Models:

Number of Models: 1 Structures

Sample Details:

1.0 mM DNA (5'-D(*AP*TP*GP*GP*TP*BGR*CP*TP*C)-3'), 1.0 mM RNA (5'-R(*GP*AP*GP*CP*AP*CP*CP*AP*U)-3'), 50 mM sodium chloride, 10 mM sodium phosphate, 0.5 mM EDTA, 0.3 uM DSS, 90% H2O/10% D2O 90% H2O/10% D2O