NDB ID: PD0952 PDB ID: 2O8C 
Title:
HUMAN MUTSALPHA (MSH2/MSH6) BOUND TO ADP AND AN O6-METHYL-GUANINE T MISPAIR
Molecular Description:
DNA mismatch repair protein Msh2/DNA mismatch repair protein Msh6/DNA Complex
Deposited:
2006-12-12
Released:
2007-06-05
Structural Keywords:
B DOUBLE HELIX
Nucleic Acid Sequence:
Click to show/hide 2 nucleic acid sequences
Chain E
(DG)(DA)(DA)(DC)(DC)(DG)(DC)(6OG)(DC)(DG)(DC)(DT)(DA)(DG)(DG)
Chain F
(DC)(DC)(DT)(DA)(DG)(DC)(DG)(DT)(DG)(DC)(DG)(DG)(DT)(DT)(DC)
Protein Sequence:
Click to show/hide 2 protein sequences
Chain A
MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVL SKMNFESFV
KDLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQ VGVGYVDSIQRKLGLCEF
PDNDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIYQD LNRLLKGKKGEQMNSAVLPEMENQVAV
SSLSAVIKFLELLSDDSNFGQFELTTFDFSQYMKLDIAAVRALNLFQGSVEDT TGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRI
EERLNLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAAN LQDCYRLYQGINQLPNVIQALEKHEGKHQKLLLAVFVTPLTDLRS
DFSKFQEMIETTLDMDQVENHEFLVKPSFDPNLSE LREIMNDLEKKMQSTLISAARDLGLDPGKQIKLDSSAQFGYYFRVTCKEEKVLR
NNKNFSTVDIQKNGVKFTNSKLTSLN EEYTKNKTEYEEAQDAIVKEIVNISSGYVEPMQTLNDVLAQLDAVVSFAHVSNGAPVPYVRPA
ILEKGQGRIILKASRHA CVEVQDEIAFIPNDVYFEKDKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARV
GAGDSQLK GVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATKIGAFCMFATHFHELTALANQIPTVNNL
HVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFPKHVIECAKQKALELEEFQYIGESQGYDIMEPAAKKCYLEREQG EKIIQEFLS
KVKQMPFTEMSEENITIKLKQLKAEVIAKNNSFVNEIISRIKVTT
Chain B
MGSAPQNSESQAHVSGGGDDSSRPTVWYHETLEWLKEEKRRDEHRRRPDHPDFDASTLYVPEDFLNSCTPGMRKWWQIKS QNFDLVICY
KVGKFYELYHMDALIGVSELGLVFMKGNWAHSGFPEIAFGRYSDSLVQKGYKVARVEQTETPEMMEARCRK MAHISKYDRVVRREICRI
ITKGTQTYSVLEGDPSENYSKYLLSLKEKEEDSSGHTRAYGVCFVDTSLGKFFIGQFSDDRH CSRFRTLVAHYPPVQVLFEKGNLSKET
KTILKSSLSCSLQEGLIPGSQFWDASKTLRTLLEEEYFREKLSDGIGVMLPQV LKGMTSESDSIGLTPGEKSELALSALGGCVFYLKKC
LIDQELLSMANFEEYIPLDSDTVSTTRSGAIFTKAYQRMVLDAV TLNNLEIFLNGTNGSTEGTLLERVDTCHTPFGKRLLKQWLCAPLC
NHYAINDRLDAIEDLMVVPDKISEVVELLKKLPDL ERLLSKIHNVGSPLKSQNHPDSRAIMYEETTYSKKKIIDFLSALEGFKVMCKII
GIMEEVADGFKSKILKQVISLQTKNP EGRFPDLTVELNRWDTAFDHEKARKTGLITPKAGFDSDYDQALADIRENEQSLLEYLEKQRNR
IGCRTIVYWGIGRNRYQ LEIPENFTTRNLPEEYELKSTKKGCKRYWTKTIEKKLANLINAEERRDVSLKDCMRRLFYNFDKNYKDWQSA
VECIAVLD VLLCLANYSRGGDGPMCRPVILLPEDTPPFLELKGSRHPCITKTFFGDDFIPNDILIGCEEEEQENGKAYCVLVTGPNMG
GKSTLMRQAGLLAVMAQMGCYVPAEVCRLTPIDRVFTRLGASDRIMSGESTFFVELSETASILMHATAHSLVLVDELGRG TATFDGTAI
ANAVVKELAETIKCRTLFSTHYHSLVEDYSQNVAVRLGHMACMVENECEDPSQETITFLYKFIKGACPKSY GFNAARLANLPEEVIQKG
HRKAREFEKMNQSLRLFREVCLASERSTVDAEAVHKLLTLIKEL
Primary Citation:
Warren, J.J., Pohlhaus, T.J., Changela, A., Iyer, R.R., Modrich, P.L., Beese, L.S.
Structure of the Human MutSalpha DNA Lesion Recognition Complex. 
Mol.Cell, 26, pp. 579 - 592, 2007.
Experimental Information:
X-RAY DIFFRACTION
Space Group:
P 43 3 2
Cell Constants:
a = 259.81 b = 259.81 c = 259.81 (Ångstroms)
α = 90.0 β = 90.0 γ = 90.0 (degrees)
Refinement:
The structure was refined using the REFMAC program.
The R value is 0.258 for 42153 reflections in
the resolution range 20.0 to 3.37 Ångstroms
with Fobs > 0.0 sigma(Fobs) and with I > 0.0 sigma(I)