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NDB ID: PD1056    PDB ID: 2RBA 


Title:

STRUCTURE OF HUMAN THYMINE DNA GLYCOSYLASE BOUND TO ABASIC AND UNDAMAGED DNA

Molecular Description:

G/T mismatch-specific thymine DNA glycosylase/DNA Complex

Deposited:

2007-09-18

Released:

2008-06-17

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Maiti, A., Morgan, M.T., Pozharski, E., Drohat, A.C.
Crystal structure of human thymine DNA glycosylase bound to DNA elucidates sequence-specific mismatch recognition. 
Proc.Natl.Acad.Sci.Usa, 105, pp. 8890 - 8895, 2008.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 65

Cell Constants:

a = 162.133   b = 162.133   c = 56.142 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.23211 for 19458 reflections in the resolution range 50.0 to 2.79 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)