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NDB ID: NA0304    PDB ID: 2V0G 


Title:

LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A TRNA(LEU) TRANSCRIPT WITH 5-FLUORO-1,3-DIHYDRO-1-HYDROXY-2,1- BENZOXABOROLE (AN2690) FORMING AN ADDUCT TO THE RIBOSE OF ADENOSINE- 76 IN THE ENZYME EDITING SITE.

Molecular Description:

AMINOACYL-TRNA SYNTHETASE

Deposited:

2007-05-14

Released:

2007-07-03

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Rock, F., Mao, W., Yaremchuk, A., Tukalo, M., Crepin, T., Zhou, H., Zhang, Y., Hernandez, V., Akama, T., Baker, S., Plattner, J., Shapiro, L., Martinis, S.A., Benkovic, S.J., Cusack, S., Alley, M.R.K.
An Antifungal Agent Inhibits an Aminoacyl-tRNA Synthetase by Trapping tRNA in the Editing Site. 
Science, 316, pp. 1759 - , 2007.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 1 2 1

Cell Constants:

a = 202.05   b = 125.8   c = 173.2 (Ångstroms)

α = 90.0   β = 118.71   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.249 for 43437 reflections in the resolution range 152.5 to 3.5 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)