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NDB ID: PD0777    PDB ID: 2FLL 


Title:

TERNARY COMPLEX OF HUMAN DNA POLYMERASE IOTA WITH DNA AND DTTP

Molecular Description:

DNA polymerase iota DNA Complex

Deposited:

2006-01-06

Released:

2006-12-12

Structural Keywords:

B DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Nair, D.T., Johnson, R.E., Prakash, L., Prakash, S., Aggarwal, A.K.
An incoming nucleotide imposes an anti to syn conformational change on the templating purine in the human DNA polymerase-iota active site. 
Structure, 14, pp. 749 - 755, 2006.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 65 2 2

Cell Constants:

a = 98.329   b = 98.329   c = 202.186 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.22765 for 16057 reflections in the resolution range 50.0 to 2.6 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)