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NDB ID: 2KKF    PDB ID: 2KKF 


Title:

SOLUTION STRUCTURE OF MLL CXXC DOMAIN IN COMPLEX WITH PALINDROMIC CPG DNA

Molecular Description:

Histone-lysine N-methyltransferase HRX (E.C.2.1.1.43)

Deposited:

2009-06-18

Released:

2009-12-08

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Cierpicki, T., Risner, L.E., Grembecka, J., Lukasik, S.M., Popovic, R., Omonkowska, M., Shultis, D.D., Zeleznik-Le, N.J., Bushweller, J.H.
Structure of the MLL CXXC domain-DNA complex and its functional role in MLL-AF9 leukemia. 
Nat.Struct.Mol.Biol., 17, pp. 62 - 68, 2010.

Experimental Information:

SOLUTION NMR

Number of Models:

Number of Models: 10 Structures

Sample Details:

1 mM [U-98% 13C; U-98% 15N] CXXC domain-1, 1 mM DNA (5'-D(*DCP*DCP*DCP*DTP*DGP*DCP*DGP*DCP*DAP*DGP*DGP*DG)-3')-2, 95% H2O/5% D2O 95% H2O/5% D2O