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NDB ID: PD0973    PDB ID: 2OXM 


Title:

CRYSTAL STRUCTURE OF A UNG2/MODIFIED DNA COMPLEX THAT REPRESENT A STABILIZED SHORT-LIVED EXTRAHELICAL STATE IN EZYMATIC DNA BASE FLIPPING

Molecular Description:

Uracil-DNA glycosylase(E.C.3.2.2.-)/DNA Complex

Deposited:

2007-02-20

Released:

2007-10-30

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Parker, J.B., Bianchet, M.A., Krosky, D.J., Friedman, J.I., Amzel, L.M., Stivers, J.T.
Enzymatic capture of an extrahelical thymine in the search for uracil in DNA. 
Nature, 449, pp. 433 - 437, 2007.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 48.467   b = 65.567   c = 98.472 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.257 for 11397 reflections in the resolution range 29.5 to 2.5 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)