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NDB ID: PD1008    PDB ID: 2PXI 


Title:

TERNARY COMPLEX OF DNA POLYMERASE BETA WITH A DIDEOXY TERMINATED PRIMER AND 2'-DEOXYGUANOSINE 5'-BETA, GAMMA-MONOFLUOROMETHYLENE TRIPHOSPHATE

Molecular Description:

DNA polymerase beta (E.C.2.7.7.7
4.2.99.-)/DNA Complex
2'-DEOXY-5'-O-[(R)-{[(R)-[(R)-FLUORO(PHOSPHONO)METHYL](HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]GUANOSINE

Deposited:

2007-05-14

Released:

2008-01-08

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

McKenna, C.E., Kashemirov, B.A., Upton, T.G., Batra, V.K., Goodman, M.F., Pedersen, L.C., Beard, W.A., Wilson, S.H.
(R)-beta,gamma-fluoromethylene-dGTP-DNA ternary complex with DNA polymerase beta. 
J.Am.Chem.Soc., 129, pp. 15412 - 15413, 2007.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 50.6   b = 80.2   c = 55.4 (Ångstroms)

α = 90.0   β = 107.8   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.206 for 22466 reflections in the resolution range 24.09 to 2.1 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)