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NDB ID: NA0370    PDB ID: 3KQK 


Title:

THREE CONFORMATIONAL SNAPSHOTS OF THE HEPATITIS C VIRUS NS3 HELICASE REVEAL A RATCHET TRANSLOCATION MECHANISM

Molecular Description:

Serine protease/NTPase/helicase NS3 (E.C.3.4.21.98
3.6.1.15
3.6.1.-)/DNA compex

Deposited:

2009-11-17

Released:

2010-01-26

Structural Keywords:

SINGLE STRAND

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Gu, M., Rice, C.M.
Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism. 
Proc.Natl.Acad.Sci.USA, 107, pp. 521 - 528, 2010.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 45.487   b = 115.381   c = 198.739 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.0 for 24872 reflections in the resolution range 19.96 to 2.8 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)