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NDB ID: NA0491    PDB ID: 3MFI 


Title:

DNA POLYMERASE ETA IN COMPLEX WITH A CIS-SYN THYMIDINE DIMER

Molecular Description:

DNA polymerase eta (E.C.2.7.7.7)/DNA complex

Deposited:

2010-04-02

Released:

2010-06-23

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Silverstein, T.D., Johnson, R.E., Jain, R., Prakash, L., Prakash, S., Aggarwal, A.K.
Structural basis for the suppression of skin cancers by DNA polymerase eta. 
Nature, 465, pp. 1039 - 1043, 2010.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 2 2 21

Cell Constants:

a = 88.087   b = 226.962   c = 85.919 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.16475 for 81185 reflections in the resolution range 35.0 to 1.76 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)