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NDB ID: NA0375    PDB ID: 3KSA 


Title:

DETAILED STRUCTURAL INSIGHT INTO THE DNA CLEAVAGE COMPLEX OF TYPE IIA TOPOISOMERASES (CLEAVED FORM)

Molecular Description:

DNA topoisomerase 4 subunit A (E.C.5.99.1.-)
DNA topoisomerase 4 subunit B (E.C.5.99.1.-)/DNA complex

Deposited:

2009-11-21

Released:

2010-05-05

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 4 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Laponogov, I., Pan, X.-S., Veselkov, D.A., McAuley, K.E., Fisher, L.M., Sanderson, M.R.
Structural Basis of Gate-DNA Breakage and Resealing by Type II Topoisomerases 
Plos One, 5, pp. e11338 - e11338, 2010.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 32

Cell Constants:

a = 116.911   b = 116.911   c = 183.759 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1805 for 41250 reflections in the resolution range 29.403 to 3.3 Ångstroms with Fobs >  1.96 sigma(Fobs) and with I >  0.0 sigma(I)