A Portal for Three-dimensional Structural Information about Nucleic Acids
As of 19-Jan-2022 number of released structures: 11891
Search for released structures

NDB ID: NA0944    PDB ID: 3Q8Q 


Title:

HUMAN DNA POLYMERASE IOTA INCORPORATING DATP OPPOSITE 8-OXO-GUANINE

Molecular Description:

DNA polymerase iota (E.C.2.7.7.7)/DNA COMPLEX

Deposited:

2011-01-06

Released:

2011-02-23

Structural Keywords:

B DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Kirouac, K.N., Ling, H.
Unique active site promotes error-free replication opposite an 8-oxo-guanine lesion by human DNA polymerase iota. 
Proc.Natl.Acad.Sci.USA, 108, pp. 3210 - 3215, 2011.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 65 2 2

Cell Constants:

a = 98.731   b = 98.731   c = 202.271 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2276 for 36888 reflections in the resolution range 32.648 to 2.031 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)