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NDB ID: NA1428    PDB ID: 3UXP 


Title:

CO-CRYSTAL STRUCTURE OF RAT DNA POLYMERASE BETA MUTATOR I260Q: ENZYME-DNA-DDTTP

Molecular Description:

DNA polymerase beta (E.C.2.7.7.7
4.2.99.-)/DNA

Deposited:

2011-12-05

Released:

2012-12-05

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Gridley, C.L., Rangarajan, S., Firbank, S., Dalal, S., Sweasy, J.B., Jaeger, J.
Structural Changes in the Hydrophobic Hinge Region Adversely Affect the Activity and Fidelity of the I260Q Mutator DNA Polymerase beta. 
Biochemistry, 52, pp. 4422 - 4432, 2013.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 100.321   b = 56.607   c = 93.144 (Ångstroms)

α = 90.0   β = 102.04   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2248 for 25030 reflections in the resolution range 27.195 to 2.723 Ångstroms with Fobs >  0.09 sigma(Fobs) and with I >  0.0 sigma(I)