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NDB ID: 4OX9    PDB ID: 4OX9 


Title:

CRYSTAL STRUCTURE OF THE AMINOGLYCOSIDE RESISTANCE METHYLTRANSFERASE NPMA BOUND TO THE 30S RIBOSOMAL SUBUNIT

Molecular Description:

30S ribosomal protein S2
30S ribosomal protein S3
30S ribosomal protein S4
30S ribosomal protein S5
30S ribosomal protein S6
30S ribosomal protein S7
30S ribosomal protein S8
30S ribosomal protein S9
30S ribosomal protein S10
30S ribosomal protein S11
30S ribosomal protein S12
30S ribosomal protein S13
30S ribosomal protein S14
30S ribosomal protein S15
30S ribosomal protein S16
30S ribosomal protein S17
30S ribosomal protein S18
30S ribosomal protein S19
30S ribosomal protein S20
30S ribosomal protein S21
NpmA/RNA Complex

Deposited:

2014-02-04

Released:

2014-04-09

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 21 protein sequences

Primary Citation:

Dunkle, J.A., Vinal, K., Desai, P.M., Zelinskaya, N., Savic, M., West, D.M., Conn, G.L., Dunham, C.M.
Molecular recognition and modification of the 30S ribosome by the aminoglycoside-resistance methyltransferase NpmA. 
Proc.Natl.Acad.Sci.USA, 111, pp. 6275 - 6280, 2014.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 41 21 2

Cell Constants:

a = 403.52   b = 403.52   c = 176.61 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.234 for 141742 reflections in the resolution range 49.715 to 3.8035 Ångstroms with Fobs >  1.34 sigma(Fobs) and with I >  0.0 sigma(I)